120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
一种新型中药软膏对大鼠模型机械性痛觉超敏的镇痛疗效
Authors Liu H, Deng J, Wei J, Wu J , Gan Y, Hu Y , Mo H
Received 10 November 2025
Accepted for publication 3 February 2026
Published 10 February 2026 Volume 2026:19 575860
DOI https://doi.org/10.2147/JPR.S575860
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Houman Danesh
Huan Liu,1,* Juan Deng,2,* Jiao Wei,3 Juan Wu,1 Yi Gan,1 Yongqun Hu,1,* HongMei Mo1,*
1Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China; 2College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 3Nursing Department, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yongqun Hu, Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China, Tel +86-27-87169053, Email 905725535@qq.com HongMei Mo, Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China, Tel +86-27-87169053, Email 309794528@qq.com
Background: Effective management of procedure-related pain, such as venipuncture, is a critical clinical need. The Eutectic Mixture of Local Anesthetics (EMLA) cream is a standard topical analgesic but has limitations including contraindications and potential adverse effects. The Cortex Erythrinae formula recorded in the Golden Mirror of Medicine is traditionally used to dispel wind-dampness, unblock collaterals, and relieve arthralgia.
Objective: This study aimed to develop a novel Traditional Chinese Medicine (TCM) ointment based on classical prescriptions and to evaluate its efficacy against mechanical allodynia, using EMLA cream as a positive control.
Methods: Fifty male Sprague-Dawley rats were randomly allocated to five groups (n=10). Mechanical allodynia was induced; the mechanical withdrawal threshold (MWT), pain-related behaviors, skin irritation, and systemic toxicity were assessed following topical application of low-, medium-, or high-concentration TCM ointment, EMLA cream, or blank vehicle.
Results: High-concentration TCM ointment significantly elevated MWT (P < 0.001 vs EMLA) and reduced paw-licking and writhing responses, without inducing skin irritation or systemic toxicity.
Conclusion: The high-concentration TCM ointment provided rapid (within 20 min), superior, and cost-effective analgesia with an excellent safety profile, suggesting its promise as an alternative to EMLA for managing mechanical allodynia.
Plain Language Summary: This study developed a new Traditional Chinese Medicine (TCM) ointment inspired by a classical formula. Tested in a rat model of pain, this high-concentration ointment provided faster and stronger pain relief compared to the commonly used EMLA cream, without causing skin irritation or other safety concerns. The results suggest this TCM ointment could be a promising, safe, and cost-effective alternative topical analgesic.
Keywords: EMLA, herbal medicine, mechanical allodynia, topical analgesia, traditional chinese medicine, von Frey test
1Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China; 2College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 3Nursing Department, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yongqun Hu, Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China, Tel +86-27-87169053, Email 905725535@qq.com HongMei Mo, Department of Pediatric, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China, Tel +86-27-87169053, Email 309794528@qq.com
Background: Effective management of procedure-related pain, such as venipuncture, is a critical clinical need. The Eutectic Mixture of Local Anesthetics (EMLA) cream is a standard topical analgesic but has limitations including contraindications and potential adverse effects. The Cortex Erythrinae formula recorded in the Golden Mirror of Medicine is traditionally used to dispel wind-dampness, unblock collaterals, and relieve arthralgia.
Objective: This study aimed to develop a novel Traditional Chinese Medicine (TCM) ointment based on classical prescriptions and to evaluate its efficacy against mechanical allodynia, using EMLA cream as a positive control.
Methods: Fifty male Sprague-Dawley rats were randomly allocated to five groups (n=10). Mechanical allodynia was induced; the mechanical withdrawal threshold (MWT), pain-related behaviors, skin irritation, and systemic toxicity were assessed following topical application of low-, medium-, or high-concentration TCM ointment, EMLA cream, or blank vehicle.
Results: High-concentration TCM ointment significantly elevated MWT (P < 0.001 vs EMLA) and reduced paw-licking and writhing responses, without inducing skin irritation or systemic toxicity.
Conclusion: The high-concentration TCM ointment provided rapid (within 20 min), superior, and cost-effective analgesia with an excellent safety profile, suggesting its promise as an alternative to EMLA for managing mechanical allodynia.
Plain Language Summary: This study developed a new Traditional Chinese Medicine (TCM) ointment inspired by a classical formula. Tested in a rat model of pain, this high-concentration ointment provided faster and stronger pain relief compared to the commonly used EMLA cream, without causing skin irritation or other safety concerns. The results suggest this TCM ointment could be a promising, safe, and cost-effective alternative topical analgesic.
Keywords: EMLA, herbal medicine, mechanical allodynia, topical analgesia, traditional chinese medicine, von Frey test