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已发表论文
老年多病共存卒中住院患者药物相关问题识别及健康相关生活质量评估
Authors Yao W , Shao Y, Li T, Wang S, Gao L, Huang P, Yan J
Received 17 November 2025
Accepted for publication 31 January 2026
Published 10 February 2026 Volume 2026:15 577714
DOI https://doi.org/10.2147/IPRP.S577714
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Walid Al-Qerem
Wenyi Yao,1,2,* Yanqi Shao,3,* Tingting Li,4 Siyi Wang,4 Li Gao,4 Ping Huang,2,4 Jieping Yan2,4
1School of Pharmacy, Hangzhou Normal University, Hangzhou, People’s Republic of China; 2The Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, People’s Republic of China; 3Comprehensive Stroke Center, Department of Neurology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, People’s Republic of China; 4Center for Clinical Pharmacy, Department of Pharmacy, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jieping Yan, The Second School of Clinical Medicine, Hangzhou Normal University, 158 Shangtang Road, Hangzhou, 310014, People’s Republic of China, Tel +86-0571-85893117, Email yanjieping@hmc.edu.cn
Background: This study seeks to identify and assess the severity of drug-related problems (DRPs), analyze risk factors and evaluate the impact of DRPs on the health-related quality of life (HRQoL) among elderly multimorbid inpatients with stroke in the Comprehensive Stroke Center (CSC) in China.
Methods: A two-year retrospective study was conducted at a tertiary hospital among elderly multimorbid inpatients with stroke. Medication review, HRQoL assessment and stroke-associated clinical scales assessment by clinical pharmacists or the medical team.
Results: An analysis of 592 patients revealed 576 DRPs. The mean age of patients was 73.64 ± 7.96 years old. 583 (55.6%) cases had at least one DRP, with an average of 1.53 ± 0.94 DRPs per patient. The most common multimorbidity pattern was co-existing hypertension and stroke (17.4%). “Drug selection, C1” emerged as the predominant cause of DRPs (54.0%; 311/576), followed by “Patient related, C7” (18.2%; 105/576). Most DRPs (79.3%, 457/576) were low severity (B-D); the remaining 20.7% (119/576) were high severity (E-H). Increased hospital length of stays (LOS) and coexisting atrial fibrillation were identified as significant factors influencing the occurrence of DRPs (p < 0.05). The quantity of DRPs showed a weak negative correlation with HRQoL scores (r = − 0.291, p < 0.001), as well as moderate positive correlations with both the mRS scores (r = 0.304, p < 0.001) and the NIHSS scores (r = 0.306, p < 0.001).
Conclusion: DRPs are prevalent among elderly multimorbid inpatients with stroke in CSC and are mainly caused by drug selection and patient-related problems. Prolonged hospitalization days and the presence of atrial fibrillation were identified as significant risk factors for occurrence of DRPs in elderly multimorbid inpatients with stroke. Pharmaceutical services of medication review could assist in the identification of DRPs at the CSC.
Keywords: clinical pharmacist, elderly inpatients, multimorbidity, drug-related problems, health-related quality of life
1School of Pharmacy, Hangzhou Normal University, Hangzhou, People’s Republic of China; 2The Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, People’s Republic of China; 3Comprehensive Stroke Center, Department of Neurology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, People’s Republic of China; 4Center for Clinical Pharmacy, Department of Pharmacy, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jieping Yan, The Second School of Clinical Medicine, Hangzhou Normal University, 158 Shangtang Road, Hangzhou, 310014, People’s Republic of China, Tel +86-0571-85893117, Email yanjieping@hmc.edu.cn
Background: This study seeks to identify and assess the severity of drug-related problems (DRPs), analyze risk factors and evaluate the impact of DRPs on the health-related quality of life (HRQoL) among elderly multimorbid inpatients with stroke in the Comprehensive Stroke Center (CSC) in China.
Methods: A two-year retrospective study was conducted at a tertiary hospital among elderly multimorbid inpatients with stroke. Medication review, HRQoL assessment and stroke-associated clinical scales assessment by clinical pharmacists or the medical team.
Results: An analysis of 592 patients revealed 576 DRPs. The mean age of patients was 73.64 ± 7.96 years old. 583 (55.6%) cases had at least one DRP, with an average of 1.53 ± 0.94 DRPs per patient. The most common multimorbidity pattern was co-existing hypertension and stroke (17.4%). “Drug selection, C1” emerged as the predominant cause of DRPs (54.0%; 311/576), followed by “Patient related, C7” (18.2%; 105/576). Most DRPs (79.3%, 457/576) were low severity (B-D); the remaining 20.7% (119/576) were high severity (E-H). Increased hospital length of stays (LOS) and coexisting atrial fibrillation were identified as significant factors influencing the occurrence of DRPs (p < 0.05). The quantity of DRPs showed a weak negative correlation with HRQoL scores (r = − 0.291, p < 0.001), as well as moderate positive correlations with both the mRS scores (r = 0.304, p < 0.001) and the NIHSS scores (r = 0.306, p < 0.001).
Conclusion: DRPs are prevalent among elderly multimorbid inpatients with stroke in CSC and are mainly caused by drug selection and patient-related problems. Prolonged hospitalization days and the presence of atrial fibrillation were identified as significant risk factors for occurrence of DRPs in elderly multimorbid inpatients with stroke. Pharmaceutical services of medication review could assist in the identification of DRPs at the CSC.
Keywords: clinical pharmacist, elderly inpatients, multimorbidity, drug-related problems, health-related quality of life