120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
影响烟雾病发病和手术结局的风险因素
Authors Cao X, Wang L, Ma Z, Xi W, Li Y, Zhang S, Zhang T, Sun G
Received 18 August 2025
Accepted for publication 26 January 2026
Published 11 February 2026 Volume 2026:19 561544
DOI https://doi.org/10.2147/JMDH.S561544
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jacqueline Dunbar-Jacob
Xuhua Cao,1 Liyi Wang,2 Zhizhao Ma,1 Wang Xi,1 Yanan Li,1 Shiyuan Zhang,1 Tao Zhang,1 Guozhu Sun1
1Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department of Hospital Infection-Control, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China
Correspondence: Guozhu Sun, Department of Neurosurgery, The Second Hospital of Hebei Medical University, No. 215 of Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, People’s Republic of China, Tel +86 13930485399, Email guozhusunsgz01@126.com
Objective: The aim of this study is to explore the risk factors associated with the onset and clinical progression of moyamoya disease (MMD), as well as the outcomes of combined revascularization surgery (RS).
Methods: A retrospective analysis was performed on the medical records of 226 individuals diagnosed with MMD who underwent combined RS at the Department of Neurosurgery in 2022. Binary logistic regression analysis was used to identify risk factors related to the occurrence of cerebral ischemia (CIS), postoperative complications, lateralization of MMD involvement, progression from unilateral to bilateral MMD, and disease severity in cases presenting with CIS. Surgical effectiveness was assessed during follow-up.
Results: Hypertension (odds ratio [OR] = 1.816, 95% confidence interval [CI]: 1.031– 3.197) and higher preoperative modified Rankin Scale scores (OR = 5.164, 95% CI: 1.145– 23.295) were identified as independent risk factors for CIS. Male sex (OR = 4.219, 95% CI: 1.470– 12.195) and age ≥ 50 years (OR = 3.979, 95% CI: 1.494– 10.598) were independent predictors of postoperative complications following RS. No independent factors were associated with the affected side or bilateral progression of MMD (P > 0.05). Disease severity in patients with CIS was influenced by both Suzuki staging and age. The effective rate of RS at 3– 6 months postoperatively was 96.46%.
Conclusion: Early intervention is recommended, particularly for male patients and those with modifiable risk factors such as hypertension. RS should ideally be performed during the early stages of Suzuki classification and before the age of 50 to reduce the risk of postoperative complications. For patients with advanced Suzuki stage or aged ≥ 50 years, comprehensive perioperative risk assessments and tailored postoperative management strategies are essential to ensure optimal surgical outcomes.
Keywords: affected side, cerebral ischemia, combined revascularization surgery, moyamoya disease, mRS score, Suzuki staging
1Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department of Hospital Infection-Control, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China
Correspondence: Guozhu Sun, Department of Neurosurgery, The Second Hospital of Hebei Medical University, No. 215 of Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, People’s Republic of China, Tel +86 13930485399, Email guozhusunsgz01@126.com
Objective: The aim of this study is to explore the risk factors associated with the onset and clinical progression of moyamoya disease (MMD), as well as the outcomes of combined revascularization surgery (RS).
Methods: A retrospective analysis was performed on the medical records of 226 individuals diagnosed with MMD who underwent combined RS at the Department of Neurosurgery in 2022. Binary logistic regression analysis was used to identify risk factors related to the occurrence of cerebral ischemia (CIS), postoperative complications, lateralization of MMD involvement, progression from unilateral to bilateral MMD, and disease severity in cases presenting with CIS. Surgical effectiveness was assessed during follow-up.
Results: Hypertension (odds ratio [OR] = 1.816, 95% confidence interval [CI]: 1.031– 3.197) and higher preoperative modified Rankin Scale scores (OR = 5.164, 95% CI: 1.145– 23.295) were identified as independent risk factors for CIS. Male sex (OR = 4.219, 95% CI: 1.470– 12.195) and age ≥ 50 years (OR = 3.979, 95% CI: 1.494– 10.598) were independent predictors of postoperative complications following RS. No independent factors were associated with the affected side or bilateral progression of MMD (P > 0.05). Disease severity in patients with CIS was influenced by both Suzuki staging and age. The effective rate of RS at 3– 6 months postoperatively was 96.46%.
Conclusion: Early intervention is recommended, particularly for male patients and those with modifiable risk factors such as hypertension. RS should ideally be performed during the early stages of Suzuki classification and before the age of 50 to reduce the risk of postoperative complications. For patients with advanced Suzuki stage or aged ≥ 50 years, comprehensive perioperative risk assessments and tailored postoperative management strategies are essential to ensure optimal surgical outcomes.
Keywords: affected side, cerebral ischemia, combined revascularization surgery, moyamoya disease, mRS score, Suzuki staging