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已发表论文
黑老虎在类风湿关节炎中的应用前景和未来展望
Authors Ouyang F, Xi X, Liang Y, Wang M, Liu M, Jin X, Li H, Liu J, Hu X
Received 20 September 2025
Accepted for publication 14 January 2026
Published 11 February 2026 Volume 2026:20 569093
DOI https://doi.org/10.2147/DDDT.S569093
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Anastasios Lymperopoulos
Fan Ouyang,1,2,* Xiuli Xi,2,* Yun Liang,1,* Min Wang,2,3 Mei Liu,2 Xiaoyan Jin,4 Hui Li,2 Jianxin Liu,2,3 Xuguang Hu1
1School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, People’s Republic of China; 2School of Pharmaceutical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Sino-Pakistan Center on Traditional Chinese Medicine, Hunan University of Medicine, Huaihua, Hunan, 418000, People’s Republic of China; 3School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, People’s Republic of China; 4School of Pharmaceutical Sciences, Xinjiang Medical University, Wulumuqi, Xinjiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xuguang Hu, Guangdong Pharmaceutical University, 280 Outer Ring East Road, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou, Guangdong, 510080, People’s Republic of China, Email huxuguang@gdpu.edu.cn Jianxin Liu, Hunan University of Medicine, 492 Jinxi South Road, Hecheng District, Huaihua, Hunan, 418000, People’s Republic of China, Email jxliu@hnmu.edu.cn
Abstract: Kadsura coccinea (Lem). A.C.Sm. has a long history of use in traditional Dong medicine for activating Qi, relieving pain, and dispersing blood stasis. It has garnered increasing attention for treating rheumatoid arthritis (RA), a condition associated with synovial inflammation and tissue damage. K. coccinea L. effects anti-RA by eliminating reactive oxygen species and directly or indirectly inhibiting lipid peroxidation. This review summarizes its potential therapeutic effects on RA through regulating inflammatory cytokines, reducing oxidative stress, and targeting specific cells and pathways, forecasting its future application prospects.
Keywords: Kadsura coccinea Lem. A.C.Sm., rheumatoid arthritis, triterpenoids, sesquiterpenes, antioxidant, immunomodulatory
1School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, People’s Republic of China; 2School of Pharmaceutical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Sino-Pakistan Center on Traditional Chinese Medicine, Hunan University of Medicine, Huaihua, Hunan, 418000, People’s Republic of China; 3School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, People’s Republic of China; 4School of Pharmaceutical Sciences, Xinjiang Medical University, Wulumuqi, Xinjiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xuguang Hu, Guangdong Pharmaceutical University, 280 Outer Ring East Road, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou, Guangdong, 510080, People’s Republic of China, Email huxuguang@gdpu.edu.cn Jianxin Liu, Hunan University of Medicine, 492 Jinxi South Road, Hecheng District, Huaihua, Hunan, 418000, People’s Republic of China, Email jxliu@hnmu.edu.cn
Abstract: Kadsura coccinea (Lem). A.C.Sm. has a long history of use in traditional Dong medicine for activating Qi, relieving pain, and dispersing blood stasis. It has garnered increasing attention for treating rheumatoid arthritis (RA), a condition associated with synovial inflammation and tissue damage. K. coccinea L. effects anti-RA by eliminating reactive oxygen species and directly or indirectly inhibiting lipid peroxidation. This review summarizes its potential therapeutic effects on RA through regulating inflammatory cytokines, reducing oxidative stress, and targeting specific cells and pathways, forecasting its future application prospects.
Keywords: Kadsura coccinea Lem. A.C.Sm., rheumatoid arthritis, triterpenoids, sesquiterpenes, antioxidant, immunomodulatory