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已发表论文
非散光型可植入式 Collamer 晶体植入术后疑似头孢呋辛诱导囊样黄斑水肿：一例病例报告
Received 20 September 2025
Accepted for publication 15 January 2026
Published 11 February 2026 Volume 2026:19 566975
DOI https://doi.org/10.2147/IMCRJ.S566975
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Tanvi Dhere
Rong Li,1,2 Qianyin Chen,2 Jinglin Zhang2
1Department of Fundus Diseases, Aier Eye Hospital, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Ophthalmology, The First Affiliated Hospital,Jinan University, Guangzhou, Guangdong, People’s Republic of China
Correspondence: Jinglin Zhang, Department of Ophthalmology, The First Affiliated Hospital, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, Guangdong, 510630, People’s Republic of China, Email zhjinglin@126.com
Purpose: We present a rare case of suspected cefuroxime-induced cystoid macular edema (CME) subsequent to non-toric implantable collamer lens (ICL) surgery.
Case Presentation: A 23-year-old lady with high myopia underwent refractive ICL implantation in both eyes. On the first day, the right eye was performed ICL implantation first, and postoperative uncorrected distance visual acuity (UDVA) was improved to 20/20. On the following day, the left eye underwent ICL implantation. Surprisingly, postoperative UDVA dropped to 20/63 with no improvement upon correction. At the end of each surgery, 0.1 mL of cefuroxime (1.5 mg/0.1 mL) will be injected into the anterior chamber. Scanning laser ophthalmoscopy (SLO) revealed macular edema in the left eye, followed by optical coherence tomography (OCT) confirming CME and serous retinal detachment. With the treatment of pranoprofen and prednisone, the CME decreased significantly and UDVA was increasing on the fifth postoperative day. At six-month follow up, the CME had completely subsided and UDVA reached to 20/20.
Conclusion: Acute CME after ICL implantation, anatomically and temporally aligned with intracameral cefuroxime injection and lacking other inflammatory or vascular triggers, strongly points to intracameral cefuroxime ocular toxic syndrome (ICOTS). Ophthalmologists should be aware that suboptimal visual recovery after ICL surgery may indicate CME and must attend to the dose safety of intracameral cefuroxime.
Keywords: implantable collamer lens, cystoid macular edema, intracameral cefuroxime ocular toxic syndrome
1Department of Fundus Diseases, Aier Eye Hospital, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Ophthalmology, The First Affiliated Hospital,Jinan University, Guangzhou, Guangdong, People’s Republic of China
Correspondence: Jinglin Zhang, Department of Ophthalmology, The First Affiliated Hospital, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, Guangdong, 510630, People’s Republic of China, Email zhjinglin@126.com
Purpose: We present a rare case of suspected cefuroxime-induced cystoid macular edema (CME) subsequent to non-toric implantable collamer lens (ICL) surgery.
Case Presentation: A 23-year-old lady with high myopia underwent refractive ICL implantation in both eyes. On the first day, the right eye was performed ICL implantation first, and postoperative uncorrected distance visual acuity (UDVA) was improved to 20/20. On the following day, the left eye underwent ICL implantation. Surprisingly, postoperative UDVA dropped to 20/63 with no improvement upon correction. At the end of each surgery, 0.1 mL of cefuroxime (1.5 mg/0.1 mL) will be injected into the anterior chamber. Scanning laser ophthalmoscopy (SLO) revealed macular edema in the left eye, followed by optical coherence tomography (OCT) confirming CME and serous retinal detachment. With the treatment of pranoprofen and prednisone, the CME decreased significantly and UDVA was increasing on the fifth postoperative day. At six-month follow up, the CME had completely subsided and UDVA reached to 20/20.
Conclusion: Acute CME after ICL implantation, anatomically and temporally aligned with intracameral cefuroxime injection and lacking other inflammatory or vascular triggers, strongly points to intracameral cefuroxime ocular toxic syndrome (ICOTS). Ophthalmologists should be aware that suboptimal visual recovery after ICL surgery may indicate CME and must attend to the dose safety of intracameral cefuroxime.
Keywords: implantable collamer lens, cystoid macular edema, intracameral cefuroxime ocular toxic syndrome