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已发表论文
胎儿颈项透明层测量值与妊娠结局的关联
Authors Zhao XN, Chang J, Sun HG, Meng H, Yao Y, Deng C, Gu YJ
Received 13 October 2025
Accepted for publication 23 January 2026
Published 12 February 2026 Volume 2026:18 574073
DOI https://doi.org/10.2147/IJWH.S574073
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Matteo Frigerio
Xiang-Na Zhao,1,* Jing Chang,2,* Hao-Gang Sun,1 Hua Meng,3 Yuan Yao,1 Chao Deng,4 Ya-juan Gu5
1First Affiliated Hospital, Shihezi University, Shihezi, 832008, People’s Republic of China; 2Shihezi University School of Medicine, Shihezi, 832008, People’s Republic of China; 3Department of Pharmacy, First Affiliated Hospital, Shihezi University, Shihezi, 832008, People’s Republic of China; 4Department of Anesthesiology, First Affiliated Hospital, Shihezi University, Shihezi, 832008, People’s Republic of China; 5Department of Gynecology and Obstetrics, First Affiliated Hospital,Shihezi University, Shihezi, 832008, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ya-juan Gu, Department of Gynecology and Obstetrics, First Affiliated Hospital, Shihezi University, No. 107, North 2nd Road, Hongshan Sub-District, Shihezi, 832008, Xinjiang Uygur Autonomous Region, People’s Republic of China, Tel +8618703096536, Email yajuangu_gyjshz1fy@126.com Chao Deng, Department of Anesthesiology, First Affiliated Hospital, Shihezi University, No. 107, North 2nd Road, Hongshan Sub-District, Shihezi, 832008, Xinjiang Uygur Autonomous Region, People’s Republic of China, Tel +8613565558780, Email dengchaodco@126.com
Objective: To explore the optimal cutoff value of fetal nuchal translucency (NT) in the Shihezi region and analyze the predictive value of NT and high-risk factors for pregnancy outcomes.
Methods: This retrospective study included pregnant women who underwent NT screening at the First Affiliated Hospital of Shihezi University between January 2021 and December 2023. Prenatal examination results and pregnancy outcomes were collected and analyzed. The optimal cutoff value of NT for predicting pregnancy outcomes was calculated.
Results: Using NT=2.5mm as the cutoff value, three groups were defined (< 2.5mm, 2.5– 3.5mm, ≥ 3.5mm). For NT≥ 2.0mm, the AUC for predicting outcomes was 0.652 (P< 0.001). NT thickening was significantly associated with ≥ 2 abnormalities in soft ultrasound indicators, structural abnormalities (P< 0.001), chromosomal abnormalities (P=0.008), and adverse outcomes (P< 0.001). Compared with the NT< 2.5 mm group, the risk of adverse outcomes increased with NT thickness (OR=2.009, 95% CI: 1.472– 2.743, for 2.5– 3.5mm; OR=13.090, 95% CI: 6.571– 26.074, for ≥ 3.5mm). The top three adverse pregnancy outcomes were: 210 cases of macrosomia (7%), 158 cases of preterm birth (5.3%), and 109 cases of structural abnormalities (3.6%). As NT thickened, structural abnormalities, chromosomal abnormalities, and miscarriage were correlated with NT (P< 0.05). HDP was associated with fetal growth retardation and preterm birth (P< 0.001). Maternal age ≥ 35 was linked to structural abnormalities (P=0.017) and gestational diabetes mellitus (GDM) (P< 0.001).
Conclusion: NT=2.5mm is the cutoff value of NT thickening in Shihezi area; structural and chromosomal abnormalities and miscarriage are related to the degree of NT thickening; NT, age and HDP are independent risk factors affecting pregnancy outcome, and age is associated with GDM. NT cannot serve as an independent risk factor for adverse pregnancy outcomes and should be evaluated in conjunction with prenatal screening ultrasound and maternal high-risk factors.
Keywords: nuchal translucency thickness, adverse pregnancy outcomes, correlation, cutoff value, fetus
1First Affiliated Hospital, Shihezi University, Shihezi, 832008, People’s Republic of China; 2Shihezi University School of Medicine, Shihezi, 832008, People’s Republic of China; 3Department of Pharmacy, First Affiliated Hospital, Shihezi University, Shihezi, 832008, People’s Republic of China; 4Department of Anesthesiology, First Affiliated Hospital, Shihezi University, Shihezi, 832008, People’s Republic of China; 5Department of Gynecology and Obstetrics, First Affiliated Hospital,Shihezi University, Shihezi, 832008, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ya-juan Gu, Department of Gynecology and Obstetrics, First Affiliated Hospital, Shihezi University, No. 107, North 2nd Road, Hongshan Sub-District, Shihezi, 832008, Xinjiang Uygur Autonomous Region, People’s Republic of China, Tel +8618703096536, Email yajuangu_gyjshz1fy@126.com Chao Deng, Department of Anesthesiology, First Affiliated Hospital, Shihezi University, No. 107, North 2nd Road, Hongshan Sub-District, Shihezi, 832008, Xinjiang Uygur Autonomous Region, People’s Republic of China, Tel +8613565558780, Email dengchaodco@126.com
Objective: To explore the optimal cutoff value of fetal nuchal translucency (NT) in the Shihezi region and analyze the predictive value of NT and high-risk factors for pregnancy outcomes.
Methods: This retrospective study included pregnant women who underwent NT screening at the First Affiliated Hospital of Shihezi University between January 2021 and December 2023. Prenatal examination results and pregnancy outcomes were collected and analyzed. The optimal cutoff value of NT for predicting pregnancy outcomes was calculated.
Results: Using NT=2.5mm as the cutoff value, three groups were defined (< 2.5mm, 2.5– 3.5mm, ≥ 3.5mm). For NT≥ 2.0mm, the AUC for predicting outcomes was 0.652 (P< 0.001). NT thickening was significantly associated with ≥ 2 abnormalities in soft ultrasound indicators, structural abnormalities (P< 0.001), chromosomal abnormalities (P=0.008), and adverse outcomes (P< 0.001). Compared with the NT< 2.5 mm group, the risk of adverse outcomes increased with NT thickness (OR=2.009, 95% CI: 1.472– 2.743, for 2.5– 3.5mm; OR=13.090, 95% CI: 6.571– 26.074, for ≥ 3.5mm). The top three adverse pregnancy outcomes were: 210 cases of macrosomia (7%), 158 cases of preterm birth (5.3%), and 109 cases of structural abnormalities (3.6%). As NT thickened, structural abnormalities, chromosomal abnormalities, and miscarriage were correlated with NT (P< 0.05). HDP was associated with fetal growth retardation and preterm birth (P< 0.001). Maternal age ≥ 35 was linked to structural abnormalities (P=0.017) and gestational diabetes mellitus (GDM) (P< 0.001).
Conclusion: NT=2.5mm is the cutoff value of NT thickening in Shihezi area; structural and chromosomal abnormalities and miscarriage are related to the degree of NT thickening; NT, age and HDP are independent risk factors affecting pregnancy outcome, and age is associated with GDM. NT cannot serve as an independent risk factor for adverse pregnancy outcomes and should be evaluated in conjunction with prenatal screening ultrasound and maternal high-risk factors.
Keywords: nuchal translucency thickness, adverse pregnancy outcomes, correlation, cutoff value, fetus