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已发表论文
珊瑚钙载氢与地塞米松在过敏性接触性皮炎小鼠模型中的疗效比较
Authors Huang G , Wei D, Zhao W, Xu H, Wang Y, Fu X, Yang Y, Li R, Wang X, Zhou K, Luan J
Received 6 October 2025
Accepted for publication 4 February 2026
Published 12 February 2026 Volume 2026:19 571870
DOI https://doi.org/10.2147/JIR.S571870
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Anish R. Maskey
Gaoxiang Huang,1,* Dongmei Wei,2,* Wei Zhao,3 Hao Xu,4 Yankang Wang,2 Xinyao Fu,2 Ye Yang,2 Rong Li,2 Xuzhen Wang,5 Kai Zhou,6 Jing Luan1,2
1Department of Pathology and Organ Transplantation, Clinical Research Center, The 924th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force, Guilin, Guangxi, People’s Republic of China; 2Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Medical Logistics, The 924th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force, Guilin, Guangxi, People’s Republic of China; 4Institution of Basic Medical Science, Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China; 5Rizhao Life Valley Biotechnology Development Co., Ltd, Rizhao, Shandong, People’s Republic of China; 6Department of Otolaryngology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, Shaanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Luan, Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, Shaanxi, 710021, People’s Republic of China, Email 15619239851@163.com Kai Zhou Department of Otolaryngology, Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, Shaanxi, 710018, People’s Republic of China, Email cakerye@163.com
Introduction: Allergic contact dermatitis (ACD) is a common T cell-mediated delayed hypersensitivity reaction characterized by chronic skin inflammation. Coral calcium carried hydrogen (CCH), a novel solid-phase hydrogen carrier, enables sustained hydrogen release and demonstrates superior stability compared to conventional hydrogen delivery methods. However, its therapeutic potential in ACD remains unexplored.
Methods: ACD was induced in female BALB/c mice (8-week-old) using 2,4-dinitrochlorobenzene (DNCB). Mice were divided into four groups: Control, DNCB model, CCH-treated (oral CCH), and dexamethasone (DEX)-treated (oral DEX). Disease severity was assessed through dermatitis scores, scratching frequency, spleen coefficient, and histopathological analysis. Serum cytokine levels and peripheral blood immune cell profiles were evaluated to elucidate the underlying mechanisms.
Results: CCH treatment significantly ameliorated ACD symptoms, comparable to DEX, as evidenced by reduced dermatitis scores, scratching behavior, and spleen enlargement. Histologically, CCH promoted ulcer healing and more effectively suppressed epidermal hyperplasia and skin inflammation than DEX. Mechanistically, CCH selectively reduced serum IgE and IL-17 levels while decreasing lymphocyte counts and proportions. In contrast, DEX primarily inhibited monocytes and neutrophils.
Conclusion: CCH exerts its therapeutic effects by modulating lymphocyte-mediated immune responses and suppressing pro-inflammatory cytokines, offering a promising therapeutic alternative with efficacy comparable to glucocorticoids.
Keywords: allergic contact dermatitis, coral calcium carried hydrogen, anti-inflammatory effects, lymphocytes
1Department of Pathology and Organ Transplantation, Clinical Research Center, The 924th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force, Guilin, Guangxi, People’s Republic of China; 2Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Medical Logistics, The 924th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force, Guilin, Guangxi, People’s Republic of China; 4Institution of Basic Medical Science, Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China; 5Rizhao Life Valley Biotechnology Development Co., Ltd, Rizhao, Shandong, People’s Republic of China; 6Department of Otolaryngology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, Shaanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Luan, Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, Shaanxi, 710021, People’s Republic of China, Email 15619239851@163.com Kai Zhou Department of Otolaryngology, Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, Shaanxi, 710018, People’s Republic of China, Email cakerye@163.com
Introduction: Allergic contact dermatitis (ACD) is a common T cell-mediated delayed hypersensitivity reaction characterized by chronic skin inflammation. Coral calcium carried hydrogen (CCH), a novel solid-phase hydrogen carrier, enables sustained hydrogen release and demonstrates superior stability compared to conventional hydrogen delivery methods. However, its therapeutic potential in ACD remains unexplored.
Methods: ACD was induced in female BALB/c mice (8-week-old) using 2,4-dinitrochlorobenzene (DNCB). Mice were divided into four groups: Control, DNCB model, CCH-treated (oral CCH), and dexamethasone (DEX)-treated (oral DEX). Disease severity was assessed through dermatitis scores, scratching frequency, spleen coefficient, and histopathological analysis. Serum cytokine levels and peripheral blood immune cell profiles were evaluated to elucidate the underlying mechanisms.
Results: CCH treatment significantly ameliorated ACD symptoms, comparable to DEX, as evidenced by reduced dermatitis scores, scratching behavior, and spleen enlargement. Histologically, CCH promoted ulcer healing and more effectively suppressed epidermal hyperplasia and skin inflammation than DEX. Mechanistically, CCH selectively reduced serum IgE and IL-17 levels while decreasing lymphocyte counts and proportions. In contrast, DEX primarily inhibited monocytes and neutrophils.
Conclusion: CCH exerts its therapeutic effects by modulating lymphocyte-mediated immune responses and suppressing pro-inflammatory cytokines, offering a promising therapeutic alternative with efficacy comparable to glucocorticoids.
Keywords: allergic contact dermatitis, coral calcium carried hydrogen, anti-inflammatory effects, lymphocytes