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已发表论文
泌尿生殖系统软斑病的临床病理特征及 MetaPath 检测的分析效用
Received 19 November 2025
Accepted for publication 5 February 2026
Published 12 February 2026 Volume 2026:19 582917
DOI https://doi.org/10.2147/IDR.S582917
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Lin He, Fen Li
Department of Pathology, Sichuan University Affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
Correspondence: Fen Li, Department of Pathology, Sichuan University affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China, Email wjhuantian123@163.com
Purpose: To describe the clinicopathological spectrum of genitourinary malakoplakia (MPL) and to evaluate the feasibility and clinical impact of metagenomic pathogen detection (MetaPath) performed on archival formalin-fixed paraffin-embedded (FFPE) tissue.
Patients and Methods: Clinical imaging, histopathology, immunohistochemistry, special stains and MetaPath results were retrospectively analysed in five MPL cases diagnosed between January 2019 and August 2025.
Results: The cohort comprised four men and one woman with a median age of 65.4 years. Four lesions arose in the prostate and one in the bladder. Histology showed chronic granulomatous inflammation with numerous eosinophilic histiocytes containing 5– 10 μm targetoid Michaelis–Gutmann bodies. CD68 and CD163 were diffusely positive; PAS and iron stains highlighted the inclusions. MetaPath identified pathogens in 3/5 (60%) FFPE specimens (Escherichia coli in two, Pseudomonas aeruginosa in one). Antibiotic regimens were adjusted according to MetaPath results. After a median follow-up of 6 months (range 4– 8) all patients remained symptom-free.
Conclusion: MPL is frequently misdiagnosed as malignancy. MetaPath can reliably detect pathogens in archival tissue and guide targeted antimicrobial therapy, representing a valuable adjunct to conventional culture.
Keywords: malakoplakia, Michaelis–Gutmann body, malakoplakia concurrent with prostate cancer, metagenomic pathogen detection technology, special stains
Department of Pathology, Sichuan University Affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
Correspondence: Fen Li, Department of Pathology, Sichuan University affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China, Email wjhuantian123@163.com
Purpose: To describe the clinicopathological spectrum of genitourinary malakoplakia (MPL) and to evaluate the feasibility and clinical impact of metagenomic pathogen detection (MetaPath) performed on archival formalin-fixed paraffin-embedded (FFPE) tissue.
Patients and Methods: Clinical imaging, histopathology, immunohistochemistry, special stains and MetaPath results were retrospectively analysed in five MPL cases diagnosed between January 2019 and August 2025.
Results: The cohort comprised four men and one woman with a median age of 65.4 years. Four lesions arose in the prostate and one in the bladder. Histology showed chronic granulomatous inflammation with numerous eosinophilic histiocytes containing 5– 10 μm targetoid Michaelis–Gutmann bodies. CD68 and CD163 were diffusely positive; PAS and iron stains highlighted the inclusions. MetaPath identified pathogens in 3/5 (60%) FFPE specimens (Escherichia coli in two, Pseudomonas aeruginosa in one). Antibiotic regimens were adjusted according to MetaPath results. After a median follow-up of 6 months (range 4– 8) all patients remained symptom-free.
Conclusion: MPL is frequently misdiagnosed as malignancy. MetaPath can reliably detect pathogens in archival tissue and guide targeted antimicrobial therapy, representing a valuable adjunct to conventional culture.
Keywords: malakoplakia, Michaelis–Gutmann body, malakoplakia concurrent with prostate cancer, metagenomic pathogen detection technology, special stains