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已发表论文
糖尿病、肥胖和外周动脉疾病的代谢驱动因素：来自近期预测的启示
Received 25 October 2025
Accepted for publication 16 January 2026
Published 13 February 2026 Volume 2026:22 576743
DOI https://doi.org/10.2147/VHRM.S576743
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Prof. Dr. Pietro Scicchitano
Edward Jude,1,2 Hongyan Wang3
1Department of Diabetes and Endocrinology, University of Manchester, Manchester, UK; 2Department of Diabetes and Endocrinology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton under Lyne, UK; 3Department of Endocrinology, Chongqing Diabetic Foot Research Center, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, People’s Republic of China
Correspondence: Hongyan Wang, Email 1048989208@qq.com
Abstract: Peripheral artery disease (PAD) is rapidly emerging as a global health priority, with projections indicating a dramatic rise in prevalence, mortality, and disability by 2050. Recent forecasts project an approximately 220% increase in PAD prevalence, with more than 360 million individuals affected globally by mid-century, largely driven by metabolic diseases—particularly diabetes and obesity. A recent population-based study forecasting the global burden of PAD provides compelling evidence that metabolic disease is the dominant driver of this alarming trend. This commentary highlights the critical interplay between metabolic risk factors and PAD progression, underscores the disproportionate burden expected in low- and middle-income countries, and calls for urgent, integrated strategies targeting metabolic health. Without decisive action to reduce diabetes, obesity, and related metabolic disorders, the looming global PAD crisis will further strain healthcare systems and deepen health inequities worldwide.
Keywords: diabetes, obesity, peripheral artery disease, PAD
1Department of Diabetes and Endocrinology, University of Manchester, Manchester, UK; 2Department of Diabetes and Endocrinology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton under Lyne, UK; 3Department of Endocrinology, Chongqing Diabetic Foot Research Center, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, People’s Republic of China
Correspondence: Hongyan Wang, Email 1048989208@qq.com
Abstract: Peripheral artery disease (PAD) is rapidly emerging as a global health priority, with projections indicating a dramatic rise in prevalence, mortality, and disability by 2050. Recent forecasts project an approximately 220% increase in PAD prevalence, with more than 360 million individuals affected globally by mid-century, largely driven by metabolic diseases—particularly diabetes and obesity. A recent population-based study forecasting the global burden of PAD provides compelling evidence that metabolic disease is the dominant driver of this alarming trend. This commentary highlights the critical interplay between metabolic risk factors and PAD progression, underscores the disproportionate burden expected in low- and middle-income countries, and calls for urgent, integrated strategies targeting metabolic health. Without decisive action to reduce diabetes, obesity, and related metabolic disorders, the looming global PAD crisis will further strain healthcare systems and deepen health inequities worldwide.
Keywords: diabetes, obesity, peripheral artery disease, PAD