120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
术前中性粒细胞百分比/白蛋白比值（NPAR）对接受机器人辅助腹腔镜结直肠癌根治术患者短期并发症和长期预后的影响
Received 26 July 2025
Accepted for publication 13 January 2026
Published 13 February 2026 Volume 2026:19 556408
DOI https://doi.org/10.2147/JIR.S556408
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Felix Marsh-Wakefield
Jing Wang,1 Tao Hu,2 Nanhui Yu3
1Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, Hunan Province, People’s Republic of China; 3Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China
Correspondence: Nanhui Yu, Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong District, Changsha, Hunan Province, People’s Republic of China, Tel +8613875960432, Email yunanhui@csu.edu.cn
Objective: To assess the prognostic utility of the preoperative neutrophil percentage-to-albumin ratio (NPAR) for short-term complications and long-term survival in colorectal cancer patients receiving robot-assisted laparoscopic radical surgery.
Methods: This retrospective study included 230 patients with stage I–III colorectal cancer who underwent Da Vinci robot-assisted laparoscopic radical resection at the Department of Gastrointestinal Surgery, Second Xiangya Hospital of Central South University, between June 2016 and December 2024. Laboratory indicators were collected within 7 days prior to surgery, and NPAR was calculated. The optimal cutoff value of NPAR (14.75) was determined using restricted cubic spline (RCS) analysis and receiver operating characteristic (ROC) curve. Based on a cutoff value of 14.75, patients were categorized into high (≥ 14.75) and low (< 14.75) NPAR groups. Multivariate logistic regression was employed to examine the relationship between NPAR levels and postoperative complications. Additionally, Kaplan–Meier survival analysis was conducted to evaluate its influence on overall survival (OS).
Results: A significant non-linear positive association was observed between NPAR and the risk of postoperative complications (P for non-linearity = 0.008). The high NPAR group exhibited a markedly higher incidence of complications (OR = 138.53, 95% CI: 12.79– 1500.47, P < 0.001). Kaplan–Meier analysis demonstrated significantly reduced overall survival among patients with elevated NPAR (log-rank P = 6.2 × 10⁻7). Furthermore, subgroup analyses confirmed the consistent predictive performance of NPAR across diverse clinical subsets.
Conclusion: Elevated preoperative NPAR significantly predicts higher risks of complications and poorer survival following robotic surgery for colorectal cancer. As a straightforward and clinically applicable biomarker, it shows great promise for preoperative risk stratification and outcome evaluation, supporting its broader adoption in clinical practice.
Keywords: Neutrophil Percentage-to-Albumin Ratio, NPAR, colorectal cancer, robotic surgery, postoperative complications, prognosis
1Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, Hunan Province, People’s Republic of China; 3Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China
Correspondence: Nanhui Yu, Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong District, Changsha, Hunan Province, People’s Republic of China, Tel +8613875960432, Email yunanhui@csu.edu.cn
Objective: To assess the prognostic utility of the preoperative neutrophil percentage-to-albumin ratio (NPAR) for short-term complications and long-term survival in colorectal cancer patients receiving robot-assisted laparoscopic radical surgery.
Methods: This retrospective study included 230 patients with stage I–III colorectal cancer who underwent Da Vinci robot-assisted laparoscopic radical resection at the Department of Gastrointestinal Surgery, Second Xiangya Hospital of Central South University, between June 2016 and December 2024. Laboratory indicators were collected within 7 days prior to surgery, and NPAR was calculated. The optimal cutoff value of NPAR (14.75) was determined using restricted cubic spline (RCS) analysis and receiver operating characteristic (ROC) curve. Based on a cutoff value of 14.75, patients were categorized into high (≥ 14.75) and low (< 14.75) NPAR groups. Multivariate logistic regression was employed to examine the relationship between NPAR levels and postoperative complications. Additionally, Kaplan–Meier survival analysis was conducted to evaluate its influence on overall survival (OS).
Results: A significant non-linear positive association was observed between NPAR and the risk of postoperative complications (P for non-linearity = 0.008). The high NPAR group exhibited a markedly higher incidence of complications (OR = 138.53, 95% CI: 12.79– 1500.47, P < 0.001). Kaplan–Meier analysis demonstrated significantly reduced overall survival among patients with elevated NPAR (log-rank P = 6.2 × 10⁻7). Furthermore, subgroup analyses confirmed the consistent predictive performance of NPAR across diverse clinical subsets.
Conclusion: Elevated preoperative NPAR significantly predicts higher risks of complications and poorer survival following robotic surgery for colorectal cancer. As a straightforward and clinically applicable biomarker, it shows great promise for preoperative risk stratification and outcome evaluation, supporting its broader adoption in clinical practice.
Keywords: Neutrophil Percentage-to-Albumin Ratio, NPAR, colorectal cancer, robotic surgery, postoperative complications, prognosis