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已发表论文
小针刀联合运动疗法治疗膝骨关节炎的干预效果：一项系统综述和荟萃分析
Authors Xu Y , Yang Q, Xu J, Xiao N, Yang X , Yan H, Zhang J , Lu H, Liu X, Sheng L, Zhu R, Huang J, Xie J, Xie Z, Li Z
Received 22 September 2025
Accepted for publication 6 February 2026
Published 13 February 2026 Volume 2026:19 569310
DOI https://doi.org/10.2147/JPR.S569310
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Michael Überall
Yundong Xu,1,* Qianqian Yang,1,* Jin Xu,1 Niqing Xiao,1 Xiongchang Yang,2 Heguo Yan,1 Jian Zhang,1 Hongting Lu,1 Xi Liu,1 Lihe Sheng,1 Ruofan Zhu,1 Jie Huang,1 Jing Xie,1 Zhaohu Xie,1 Zhaofu Li1
1First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, People’s Republic of China; 2Department of Pharmacy, The People’s Hospital of ChuXiong Yi Autonomous Perfecture, Chuxiong, Yunnan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhaofu Li, First Clinical Medical College, Yunnan University of Chinese Medicine, No. 1076, Yuhua Road, Chenggong District, Kunming, Yunnan, 650500, People’s Republic of China, Email lzf0817@126.com
Background: Knee osteoarthritis (KOA) is a common degenerative disease. Small needle-knife (SNK) therapy combined with exercise therapy has attracted increasing attention. However, its effectiveness requires further evaluation.
Objective: To systematically evaluate the clinical efficacy of SNK combined with exercise therapy in KOA patients.
Methods: Randomized controlled trials(RCTs) comparing small needle-knife (SNK) plus exercise with exercise alone were identified from major databases (PubMed, EMBASE, Cochrane Library and others) from inception to March 14, 2025. Primary outcomes included overall treatment efficacy, pain measured by the visual analogue scale (VAS), function assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Lequesne Index, and knee stability assessed by the Lysholm score. Meta-analyses were performed using fixed- or random-effects models according to heterogeneity (I2 and Q test). Risk of bias was assessed with the Cochrane Risk of Bias 2.0 tool (RoB 2), and the certainty of evidence with the GRADE approach. The protocol was prospectively registered in PROSPERO.
Results: Ten RCTs were included. Results showed that SNK combined with exercise significantly improved clinical efficacy (RR = 1.30; 95% CI [1.19, 2.42]). Compared with exercise alone, combination therapy significantly relieved pain (VAS: MD = − 1.64; 95% CI [− 2.20, − 1.05]), improved function (WOMAC: MD = − 14.65; 95% CI [− 19.48, − 9.83]; Lequesne index: MD = − 2.23; 95% CI [− 3.59, − 0.86]), and enhanced knee stability (Lysholm score: MD = 9.20; 95% CI [1.67, 16.74]). ROB2 assessment showed that 60% of studies had low risk, and 40% had some concerns. All outcome measures were supported by high-quality evidence according to the GRADE framework.
Conclusion: The combination of SNK and exercise shows clinically significant improvements in KOA. Nevertheless, additional high-quality studies are required to corroborate these findings.
Keywords: knee osteoarthritis, small needle-knife, sports therapy, systematic review, meta-analysis
1First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, People’s Republic of China; 2Department of Pharmacy, The People’s Hospital of ChuXiong Yi Autonomous Perfecture, Chuxiong, Yunnan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhaofu Li, First Clinical Medical College, Yunnan University of Chinese Medicine, No. 1076, Yuhua Road, Chenggong District, Kunming, Yunnan, 650500, People’s Republic of China, Email lzf0817@126.com
Background: Knee osteoarthritis (KOA) is a common degenerative disease. Small needle-knife (SNK) therapy combined with exercise therapy has attracted increasing attention. However, its effectiveness requires further evaluation.
Objective: To systematically evaluate the clinical efficacy of SNK combined with exercise therapy in KOA patients.
Methods: Randomized controlled trials(RCTs) comparing small needle-knife (SNK) plus exercise with exercise alone were identified from major databases (PubMed, EMBASE, Cochrane Library and others) from inception to March 14, 2025. Primary outcomes included overall treatment efficacy, pain measured by the visual analogue scale (VAS), function assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Lequesne Index, and knee stability assessed by the Lysholm score. Meta-analyses were performed using fixed- or random-effects models according to heterogeneity (I2 and Q test). Risk of bias was assessed with the Cochrane Risk of Bias 2.0 tool (RoB 2), and the certainty of evidence with the GRADE approach. The protocol was prospectively registered in PROSPERO.
Results: Ten RCTs were included. Results showed that SNK combined with exercise significantly improved clinical efficacy (RR = 1.30; 95% CI [1.19, 2.42]). Compared with exercise alone, combination therapy significantly relieved pain (VAS: MD = − 1.64; 95% CI [− 2.20, − 1.05]), improved function (WOMAC: MD = − 14.65; 95% CI [− 19.48, − 9.83]; Lequesne index: MD = − 2.23; 95% CI [− 3.59, − 0.86]), and enhanced knee stability (Lysholm score: MD = 9.20; 95% CI [1.67, 16.74]). ROB2 assessment showed that 60% of studies had low risk, and 40% had some concerns. All outcome measures were supported by high-quality evidence according to the GRADE framework.
Conclusion: The combination of SNK and exercise shows clinically significant improvements in KOA. Nevertheless, additional high-quality studies are required to corroborate these findings.
Keywords: knee osteoarthritis, small needle-knife, sports therapy, systematic review, meta-analysis