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已发表论文
瑞马唑仑对甲状腺手术患者术后咳嗽的影响：一项随机双盲对照临床试验
Authors Liu X, Zhang T, Zhao L , Zhou X, Zhang L, Mao W, Chen L, Xie Y, Li L
Received 19 October 2025
Accepted for publication 5 February 2026
Published 13 February 2026 Volume 2026:20 575369
DOI https://doi.org/10.2147/DDDT.S575369
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Anastasios Lymperopoulos
Xianchun Liu, Ting Zhang, Li Zhao, Xuelei Zhou, Longyi Zhang, Wei Mao, Linlin Chen, Ying Xie, Linji Li
Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Nanchong Branch, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, People’s Republic of China
Correspondence: Linji Li, Email llj-stephen@163.com
Purpose: This study aimed to evaluate the inhibitory effect of remimazolam on coughing during emergence from general anesthesia in patients undergoing thyroid surgery.
Methods: Sixty-eight patients were randomly assigned to two groups (n = 34 each). After anesthesia induction, the remimazolam group (R group) received a continuous infusion of 0.4 mg/kg/h remimazolam, while the control group (C group) received an equal volume of saline until the end of surgery. Both groups were maintained with remifentanil and sevoflurane. The incidence and severity of coughing during emergence, awakening time, extubation time, and sedation scores were recorded. Heart rate and mean arterial pressure were measured at five time points: admission (T0), 2 min before intubation (T1), 2 min after intubation (T2), end of surgery (T3), and extubation (T4). Adverse events were also documented.
Results: The incidence of coughing was significantly lower in the R group (38.24%) than in the C group (76.47%) (risk difference [RD], − 38.2%; 95% CI, − 59.9% to − 16.6%; relative risk [RR], 0.50; 95% CI, 0.30– 0.82; P < 0.005). Moderate to severe coughing occurred less frequently in the R group (14.71% vs 35.29%, P = 0.029), and overall coughing severity was lower (P < 0.001). Awakening and extubation times were longer in the R group (P < 0.0001), and sedation scores were higher at response and extubation (P < 0.0001, P = 0.002). Heart rate and mean arterial pressure decreased in both groups without significant intergroup differences.
Conclusion: Remimazolam significantly reduces the incidence of coughing during emergence from general anesthesia in thyroid surgery.
Keywords: remimazolam, thyroid surgery, emergence phase of general anesthesia, coughing
Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Nanchong Branch, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, People’s Republic of China
Correspondence: Linji Li, Email llj-stephen@163.com
Purpose: This study aimed to evaluate the inhibitory effect of remimazolam on coughing during emergence from general anesthesia in patients undergoing thyroid surgery.
Methods: Sixty-eight patients were randomly assigned to two groups (n = 34 each). After anesthesia induction, the remimazolam group (R group) received a continuous infusion of 0.4 mg/kg/h remimazolam, while the control group (C group) received an equal volume of saline until the end of surgery. Both groups were maintained with remifentanil and sevoflurane. The incidence and severity of coughing during emergence, awakening time, extubation time, and sedation scores were recorded. Heart rate and mean arterial pressure were measured at five time points: admission (T0), 2 min before intubation (T1), 2 min after intubation (T2), end of surgery (T3), and extubation (T4). Adverse events were also documented.
Results: The incidence of coughing was significantly lower in the R group (38.24%) than in the C group (76.47%) (risk difference [RD], − 38.2%; 95% CI, − 59.9% to − 16.6%; relative risk [RR], 0.50; 95% CI, 0.30– 0.82; P < 0.005). Moderate to severe coughing occurred less frequently in the R group (14.71% vs 35.29%, P = 0.029), and overall coughing severity was lower (P < 0.001). Awakening and extubation times were longer in the R group (P < 0.0001), and sedation scores were higher at response and extubation (P < 0.0001, P = 0.002). Heart rate and mean arterial pressure decreased in both groups without significant intergroup differences.
Conclusion: Remimazolam significantly reduces the incidence of coughing during emergence from general anesthesia in thyroid surgery.
Keywords: remimazolam, thyroid surgery, emergence phase of general anesthesia, coughing