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已发表论文
术前星状神经节阻滞对接受双腔支气管插管患者术后咽痛与声音嘶哑的影响：前瞻性随机对照试验方案
Authors Chen Z , Tan Y , Cong P , Jin Y, Jin Y , Li N
Received 10 October 2025
Accepted for publication 22 January 2026
Published 30 January 2026 Volume 2026:19 573249
DOI https://doi.org/10.2147/JPR.S573249
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Karina Gritsenko
Zheping Chen,1,2,* Yawen Tan,2,* Peilin Cong,1,* Yuelong Jin,3 Yanwu Jin,4 Ning Li2
1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology, The Second Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, People’s Republic of China; 3Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College/ Institute of Chronic Disease Prevention and Control, Wuhu, 241002, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, 250100, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yanwu Jin, Department of Anesthesiology and Perioperative Medicine, Shandong Public Health Clinical Center, Shandong University, 2999 Gangxing West Road, Jinan, Shandong, 250100, People’s Republic of China, Email jinyanwu_aa@163.com Ning Li, Department of Anesthesiology, The Second Qilu Hospital, Cheeloo College of Medicine, Shandong University, 247 Bei Yuan Street, Jinan, Shandong, 250033, People’s Republic of China, Email lining252252@126.com
Background: Postoperative sore throat (POST) is a common complication after general anesthesia, especially following double-lumen endobronchial tube (DLT) intubation in thoracic surgery, adversely affecting recovery. Stellate ganglion block (SGB) modulates sympathetic tone and inflammation, potentially reducing airway complications, but its efficacy for POST and hoarseness after DLTs remains unclear.
Objective: To evaluate the impact of preoperative SGB on the incidence and severity of POST and hoarseness in patients undergoing DLT intubation, and to explore its effects on postoperative sleep, anxiety, depression, and hemodynamics.
Methods: In this single-center, prospective, randomized controlled trial, 124 patients scheduled for thoracic surgery with left DLT intubation are to be included. Patients will be randomly assigned in a 1:1 ratio to the SGB group or the control group. Patients in the SGB group will receive ultrasound-guided right SGB (5 mL of 0.5% ropivacaine) approximately 30 minutes before anesthesia induction. In the control group, ultrasound-guided scanning of the stellate ganglion will be conducted without performing SGB, and local lubrication with 1% tetracaine gel will be administered prior to intubation. The primary outcome is the incidence of POST at 6 hours after surgery.
Discussion: This trial will determine whether SGB can effectively reduce POST and hoarseness after DLT intubation, potentially offering a multimodal strategy to improve postoperative recovery in thoracic surgery patients.
Clinical Trial Registration: Chinese Clinical Trial Registry (ChiCTR2400092313).
Keywords: postoperative sore throat, double-lumen endobronchial tube, stellate ganglion block, postoperative sleep disturbance
1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology, The Second Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, People’s Republic of China; 3Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College/ Institute of Chronic Disease Prevention and Control, Wuhu, 241002, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, 250100, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yanwu Jin, Department of Anesthesiology and Perioperative Medicine, Shandong Public Health Clinical Center, Shandong University, 2999 Gangxing West Road, Jinan, Shandong, 250100, People’s Republic of China, Email jinyanwu_aa@163.com Ning Li, Department of Anesthesiology, The Second Qilu Hospital, Cheeloo College of Medicine, Shandong University, 247 Bei Yuan Street, Jinan, Shandong, 250033, People’s Republic of China, Email lining252252@126.com
Background: Postoperative sore throat (POST) is a common complication after general anesthesia, especially following double-lumen endobronchial tube (DLT) intubation in thoracic surgery, adversely affecting recovery. Stellate ganglion block (SGB) modulates sympathetic tone and inflammation, potentially reducing airway complications, but its efficacy for POST and hoarseness after DLTs remains unclear.
Objective: To evaluate the impact of preoperative SGB on the incidence and severity of POST and hoarseness in patients undergoing DLT intubation, and to explore its effects on postoperative sleep, anxiety, depression, and hemodynamics.
Methods: In this single-center, prospective, randomized controlled trial, 124 patients scheduled for thoracic surgery with left DLT intubation are to be included. Patients will be randomly assigned in a 1:1 ratio to the SGB group or the control group. Patients in the SGB group will receive ultrasound-guided right SGB (5 mL of 0.5% ropivacaine) approximately 30 minutes before anesthesia induction. In the control group, ultrasound-guided scanning of the stellate ganglion will be conducted without performing SGB, and local lubrication with 1% tetracaine gel will be administered prior to intubation. The primary outcome is the incidence of POST at 6 hours after surgery.
Discussion: This trial will determine whether SGB can effectively reduce POST and hoarseness after DLT intubation, potentially offering a multimodal strategy to improve postoperative recovery in thoracic surgery patients.
Clinical Trial Registration: Chinese Clinical Trial Registry (ChiCTR2400092313).
Keywords: postoperative sore throat, double-lumen endobronchial tube, stellate ganglion block, postoperative sleep disturbance