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已发表论文
Sonidegib 治疗老年局部晚期基底细胞癌患者：一例病例报告
Authors Deng Y , He P, Li C, Li G, Tao X
Received 1 December 2025
Accepted for publication 25 January 2026
Published 30 January 2026 Volume 2026:19 584651
DOI https://doi.org/10.2147/CCID.S584651
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Yuyu Deng,1– 5 Pingxiu He,1– 5 Changxia Li,1– 5 Guolan Li,1– 5 Xiaohua Tao1– 5
1Dermatology Department, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Dermatology Department, Jiangxi Provincial Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 3Dermatology Department, Candidate Branch of National Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 4Dermatology Department, Dermatology Institute of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 5Dermatology Department, The Affiliated Dermatology Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
Correspondence: Xiaohua Tao, Email taoxiaohua@126.com
Abstract: We report a case of locally advanced basal cell carcinoma (BCC) of the nose successfully treated with oral sonidegib. An 87-year-old man presented with a pruritic brown papule in the right nasolabial fold, progressively enlarging for > 10 years and ulcerated for 7 years. Histopathology confirmed nodular BCC with tumor thickness ≥ 6 mm. Sonidegib (200 mg daily) was initiated, and a complete resolution was achieved after 5 months. No recurrence or significant adverse effects were observed 4 months post-treatment.
Keywords: Sonidegib, therapy, locally advanced, basal cell carcinoma
1Dermatology Department, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Dermatology Department, Jiangxi Provincial Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 3Dermatology Department, Candidate Branch of National Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 4Dermatology Department, Dermatology Institute of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 5Dermatology Department, The Affiliated Dermatology Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
Correspondence: Xiaohua Tao, Email taoxiaohua@126.com
Abstract: We report a case of locally advanced basal cell carcinoma (BCC) of the nose successfully treated with oral sonidegib. An 87-year-old man presented with a pruritic brown papule in the right nasolabial fold, progressively enlarging for > 10 years and ulcerated for 7 years. Histopathology confirmed nodular BCC with tumor thickness ≥ 6 mm. Sonidegib (200 mg daily) was initiated, and a complete resolution was achieved after 5 months. No recurrence or significant adverse effects were observed 4 months post-treatment.
Keywords: Sonidegib, therapy, locally advanced, basal cell carcinoma