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已发表论文
炎症负荷指数与非阻塞性冠状动脉心肌梗死患者主要不良心血管事件长期风险升高相关
Authors Tao Y, Liu W, Yin J, Chen Z, Shen Q, Chen L
Received 14 October 2025
Accepted for publication 22 January 2026
Published 31 January 2026 Volume 2026:19 572612
DOI https://doi.org/10.2147/IJGM.S572612
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Yifei Tao,1,* Wei Liu,1,* Jiayu Yin,2,* Zhixian Chen,1 Qian Shen,1 Le Chen1
1Department of Cardiology, the Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China; 2Department of Cardiology, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Le Chen, Department of Cardiology, the Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China, Email 15895573897@163.com Qian Shen, Department of Cardiology, the Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China, Email sq18896557990@126.com
Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) refers to patients who meet the universal definition of acute myocardial infarction but show no significant stenosis on coronary angiography, and it is associated with a non-benign prognosis. The prognostic relevance of inflammatory burden index (IBI), a useful inflammatory biomarker, in patients with MINOCA remains to be elucidated. We evaluated the association between the IBI and long-term major adverse cardiovascular events (MACE) in MINOCA.
Methods: In this single-center retrospective cohort, we included 267 consecutive patients with clinically diagnosed MINOCA. Cox proportional hazards models assessed associations between baseline IBI and MACE. Discrimination was evaluated using receiver operating characteristic (ROC) analysis with area under the curve (AUC) comparisons by the DeLong test.
Results: Over a median follow-up of 42 (15, 56) months, 53 MACE occurred (19.9%). In multivariable models adjusting for clinical covariates and key biomarkers, IBI remained independently associated with MACE (HR 1.342, 95% CI 1.168– 1.542; P < 0.001), as did NT-proBNP (HR 1.711, 95% CI 1.446– 2.023; P < 0.001) and the ST-segment elevation (HR 1.780, 95% CI 1.031– 3.075; P = 0.039). For predicting MACE, IBI achieved an AUC of 0.737 (95% CI 0.673– 0.801), outperforming hs-CRP (AUC 0.698, 95% CI 0.630– 0.766) and NLR (AUC 0.650, 95% CI 0.564– 0.736). Patients with high IBI had a significantly higher cumulative incidence of MACE on Kaplan–Meier analysis (log-rank P < 0.001).
Conclusion: Elevated IBI is an independent risk factor of long-term MACE in MINOCA. As an inexpensive, routinely available composite biomarker, IBI may aid risk stratification and follow-up planning in MINOCA. Despite these findings, the external generalizability of this study is limited by its design.
Keywords: acute myocardial infarction, MINOCA, inflammatory burden index, PROGNOSIS, risk stratification
1Department of Cardiology, the Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China; 2Department of Cardiology, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Le Chen, Department of Cardiology, the Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China, Email 15895573897@163.com Qian Shen, Department of Cardiology, the Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People’s Republic of China, Email sq18896557990@126.com
Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) refers to patients who meet the universal definition of acute myocardial infarction but show no significant stenosis on coronary angiography, and it is associated with a non-benign prognosis. The prognostic relevance of inflammatory burden index (IBI), a useful inflammatory biomarker, in patients with MINOCA remains to be elucidated. We evaluated the association between the IBI and long-term major adverse cardiovascular events (MACE) in MINOCA.
Methods: In this single-center retrospective cohort, we included 267 consecutive patients with clinically diagnosed MINOCA. Cox proportional hazards models assessed associations between baseline IBI and MACE. Discrimination was evaluated using receiver operating characteristic (ROC) analysis with area under the curve (AUC) comparisons by the DeLong test.
Results: Over a median follow-up of 42 (15, 56) months, 53 MACE occurred (19.9%). In multivariable models adjusting for clinical covariates and key biomarkers, IBI remained independently associated with MACE (HR 1.342, 95% CI 1.168– 1.542; P < 0.001), as did NT-proBNP (HR 1.711, 95% CI 1.446– 2.023; P < 0.001) and the ST-segment elevation (HR 1.780, 95% CI 1.031– 3.075; P = 0.039). For predicting MACE, IBI achieved an AUC of 0.737 (95% CI 0.673– 0.801), outperforming hs-CRP (AUC 0.698, 95% CI 0.630– 0.766) and NLR (AUC 0.650, 95% CI 0.564– 0.736). Patients with high IBI had a significantly higher cumulative incidence of MACE on Kaplan–Meier analysis (log-rank P < 0.001).
Conclusion: Elevated IBI is an independent risk factor of long-term MACE in MINOCA. As an inexpensive, routinely available composite biomarker, IBI may aid risk stratification and follow-up planning in MINOCA. Despite these findings, the external generalizability of this study is limited by its design.
Keywords: acute myocardial infarction, MINOCA, inflammatory burden index, PROGNOSIS, risk stratification