120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
降钙素原和 C 反应蛋白动态变化在评估肺结核患者早期治疗反应中的预测价值
Authors Kong X, Pan S, Huang B, Zhao L
Received 4 October 2025
Accepted for publication 16 January 2026
Published 2 February 2026 Volume 2026:19 566150
DOI https://doi.org/10.2147/IDR.S566150
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Hazrat Bilal
Xiangzhou Kong,1– 3,* Suxiang Pan,4,* Bangmin Huang,3,* Lei Zhao1
1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital North District of Anhui Medical University, Hefei, 230011, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Anhui Public Health Clinical Center, Hefei, 230011, People’s Republic of China; 3Department of Tuberculosis, Anhui Chest Hospital, Hefei, 230031, People’s Republic of China; 4Neonatal Intensive Care Unit, Affiliated Hospital of Putian University, Putian, 351146, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lei Zhao, Email ayefyzhaolei@163.com
Objective: To explore the predictive value of dynamic changes in procalcitonin (PCT) and C-reactive protein (CRP) in evaluating early treatment response in patients with pulmonary tuberculosis (PTB).
Methods: A retrospective study was conducted on 168 PTB patients from June 2022 to June 2024. Based on early treatment efficacy, patients were divided into an effective group (136 cases, 80.95%) and an ineffective group (32 cases, 19.05%). Clinical data of the two groups were compared, and variables showing significant differences were analyzed using logistic regression analysis. The predictive value was evaluated through ROC curves, nomograms, and calibration curves. The dynamic changes in PCT and CRP and their correlations with treatment outcomes were also analyzed.
Results: Significant differences were observed between the ineffective and effective groups in terms of the number of lung fields involved and pulmonary cavitary lesions (P < 0.05). Additionally, baseline levels of PCT, CRP and IL-6 were significantly higher in the ineffective group than in the effective group (P < 0.05). The number of lung fields involved, pulmonary cavitary lesions, PCT, CRP, and IL-6 were identified as independent factors influencing early treatment efficacy in PTB patients. PCT, CRP, and IL-6 demonstrated high predictive value for treatment outcomes. On days 1, 5, and 7 after treatment, PCT and CRP levels were significantly lower in the effective group than in the ineffective group (P < 0.05), with the most pronounced difference observed on day 1. Greater reductions in PCT and CRP levels were associated with better treatment outcomes and larger lesion absorption area (P < 0.05).
Conclusion: The number of lung fields involved, pulmonary cavitary lesions, PCT, CRP, and IL-6 all influence early treatment efficacy in PTB patients. Among these, dynamic changes in PCT and CRP exhibit high predictive value, providing a reliable basis for clinical assessment.
Keywords: pulmonary tuberculosis, procalcitonin, C-reactive protein, interleukin-6, pulmonary cavitary lesions
1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital North District of Anhui Medical University, Hefei, 230011, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Anhui Public Health Clinical Center, Hefei, 230011, People’s Republic of China; 3Department of Tuberculosis, Anhui Chest Hospital, Hefei, 230031, People’s Republic of China; 4Neonatal Intensive Care Unit, Affiliated Hospital of Putian University, Putian, 351146, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lei Zhao, Email ayefyzhaolei@163.com
Objective: To explore the predictive value of dynamic changes in procalcitonin (PCT) and C-reactive protein (CRP) in evaluating early treatment response in patients with pulmonary tuberculosis (PTB).
Methods: A retrospective study was conducted on 168 PTB patients from June 2022 to June 2024. Based on early treatment efficacy, patients were divided into an effective group (136 cases, 80.95%) and an ineffective group (32 cases, 19.05%). Clinical data of the two groups were compared, and variables showing significant differences were analyzed using logistic regression analysis. The predictive value was evaluated through ROC curves, nomograms, and calibration curves. The dynamic changes in PCT and CRP and their correlations with treatment outcomes were also analyzed.
Results: Significant differences were observed between the ineffective and effective groups in terms of the number of lung fields involved and pulmonary cavitary lesions (P < 0.05). Additionally, baseline levels of PCT, CRP and IL-6 were significantly higher in the ineffective group than in the effective group (P < 0.05). The number of lung fields involved, pulmonary cavitary lesions, PCT, CRP, and IL-6 were identified as independent factors influencing early treatment efficacy in PTB patients. PCT, CRP, and IL-6 demonstrated high predictive value for treatment outcomes. On days 1, 5, and 7 after treatment, PCT and CRP levels were significantly lower in the effective group than in the ineffective group (P < 0.05), with the most pronounced difference observed on day 1. Greater reductions in PCT and CRP levels were associated with better treatment outcomes and larger lesion absorption area (P < 0.05).
Conclusion: The number of lung fields involved, pulmonary cavitary lesions, PCT, CRP, and IL-6 all influence early treatment efficacy in PTB patients. Among these, dynamic changes in PCT and CRP exhibit high predictive value, providing a reliable basis for clinical assessment.
Keywords: pulmonary tuberculosis, procalcitonin, C-reactive protein, interleukin-6, pulmonary cavitary lesions