120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
牙种植体骨结合中的骨免疫调控：从异物反应到治疗性免疫调节——一项叙述性综述
Authors Jian XC, Dong YL, Zhang MM, Guo ZL
Received 16 October 2025
Accepted for publication 14 January 2026
Published 2 February 2026 Volume 2026:21 574786
DOI https://doi.org/10.2147/IJN.S574786
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Krishna Nune
Xiao-Chong Jian,1,* Yu-Lei Dong,1,2,* Miao-Miao Zhang,1,2 Zhu-Ling Guo1,2
1School of Dentistry, Hainan Medical University, Haikou, 570100, People’s Republic of China; 2Department of Health Management Center, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhu-Ling Guo, School of Dentistry, Hainan Medical University, Haikou, 570100, People’s Republic of China, Email zlguo@ynpfph.org
Background: The long-term success of dental implants depends on osseointegration, traditionally viewed as a biomechanical process. Recent osteoimmunology research reveals it as an immune-mediated phenomenon, where successful integration results from a redirected foreign body reaction termed Foreign Body Equilibrium (FBE).
Objective: This review aims to redefine osseointegration through the lens of osteoimmunology, emphasizing macrophage polarization (M1-to-M2 switch) as the pivotal determinant of implant fate, and to evaluate strategies for immunomodulatory implant design.
Methods: A comprehensive literature search was conducted using databases including PubMed, Web of Science, and Scopus. We selected and synthesized pivotal studies focusing on the cellular and molecular mechanisms of osseointegration, specifically targeting macrophage-T cell crosstalk and the RANKL-OPG axis. The review critically analyzes modulatory factors (surface topography, wettability, patient-specific conditions) and evaluates emerging therapeutic strategies such as bioactive coatings and extracellular vesicle functionalization.
Conclusion: Osseointegration is an active osteoimmune process. Harnessing immunomodulation—particularly macrophage polarization—can transform implants from passive devices to therapeutic platforms, improving outcomes in diverse clinical scenarios.
Keywords: osseointegration, foreign-body reaction, immunomodulation, dental implants, macrophage activation, bone-immune system
1School of Dentistry, Hainan Medical University, Haikou, 570100, People’s Republic of China; 2Department of Health Management Center, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhu-Ling Guo, School of Dentistry, Hainan Medical University, Haikou, 570100, People’s Republic of China, Email zlguo@ynpfph.org
Background: The long-term success of dental implants depends on osseointegration, traditionally viewed as a biomechanical process. Recent osteoimmunology research reveals it as an immune-mediated phenomenon, where successful integration results from a redirected foreign body reaction termed Foreign Body Equilibrium (FBE).
Objective: This review aims to redefine osseointegration through the lens of osteoimmunology, emphasizing macrophage polarization (M1-to-M2 switch) as the pivotal determinant of implant fate, and to evaluate strategies for immunomodulatory implant design.
Methods: A comprehensive literature search was conducted using databases including PubMed, Web of Science, and Scopus. We selected and synthesized pivotal studies focusing on the cellular and molecular mechanisms of osseointegration, specifically targeting macrophage-T cell crosstalk and the RANKL-OPG axis. The review critically analyzes modulatory factors (surface topography, wettability, patient-specific conditions) and evaluates emerging therapeutic strategies such as bioactive coatings and extracellular vesicle functionalization.
Conclusion: Osseointegration is an active osteoimmune process. Harnessing immunomodulation—particularly macrophage polarization—can transform implants from passive devices to therapeutic platforms, improving outcomes in diverse clinical scenarios.
Keywords: osseointegration, foreign-body reaction, immunomodulation, dental implants, macrophage activation, bone-immune system