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已发表论文
肝脏疾病及中医药治疗中组蛋白和非组蛋白的翻译后修饰：一项叙述性综述
Authors Xie Z , Deng Y , Zhang X, Chen J, Deng J, Fang Y, Ye X, Zhou Z
Received 23 July 2025
Accepted for publication 7 January 2026
Published 3 February 2026 Volume 2026:19 555701
DOI https://doi.org/10.2147/PGPM.S555701
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Martin H Bluth
Zhuohua Xie,1 Yanting Deng,2 Xinru Zhang,1 Jieyi Chen,1 Jiasheng Deng,2 Yibin Fang,1 Xiaoxue Ye,1 Zhipin Zhou1
1Department of Pharmacy, Liuzhou People’s Hospital, Liuzhou, Guangxi, People’s Republic of China; 2School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, People’s Republic of China
Correspondence: Zhipin Zhou, Department of Pharmacy, Liuzhou People’s Hospital, 8 Wenchang Road, Cheng Zhong District, Liuzhou, Guangxi, 545006, People’s Republic of China, Tel +86-18776921947, Email gxzhouzhipin@126.com
Abstract: Post-translational modifications (PTMs) of histones and non-histones are significant epigenetic modifications in humans, including acetylation, methylation, phosphorylation, glycosylation, and ubiquitination. These modifications regulate chromatin structure and gene expression, enabling proteins to perform their normal biological functions within cells and maintain stable expression. It is also closely related to the development process of liver diseases and plays an important role in the pathological processes of liver cancer, liver fibrosis, alcoholic fatty liver disease and non-alcoholic fatty liver disease. This article reviews the roles and pathway mechanisms mediated by post-translational modifications of histones and non-histones in these liver diseases, and briefly outlines how traditional Chinese medicine (TCM) can intervene in liver diseases by modulating protein post-translational modifications, providing new strategies for future prevention and treatment of liver diseases.
Keywords: post-translational modifications, liver disease, traditional Chinese medicine
1Department of Pharmacy, Liuzhou People’s Hospital, Liuzhou, Guangxi, People’s Republic of China; 2School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, People’s Republic of China
Correspondence: Zhipin Zhou, Department of Pharmacy, Liuzhou People’s Hospital, 8 Wenchang Road, Cheng Zhong District, Liuzhou, Guangxi, 545006, People’s Republic of China, Tel +86-18776921947, Email gxzhouzhipin@126.com
Abstract: Post-translational modifications (PTMs) of histones and non-histones are significant epigenetic modifications in humans, including acetylation, methylation, phosphorylation, glycosylation, and ubiquitination. These modifications regulate chromatin structure and gene expression, enabling proteins to perform their normal biological functions within cells and maintain stable expression. It is also closely related to the development process of liver diseases and plays an important role in the pathological processes of liver cancer, liver fibrosis, alcoholic fatty liver disease and non-alcoholic fatty liver disease. This article reviews the roles and pathway mechanisms mediated by post-translational modifications of histones and non-histones in these liver diseases, and briefly outlines how traditional Chinese medicine (TCM) can intervene in liver diseases by modulating protein post-translational modifications, providing new strategies for future prevention and treatment of liver diseases.
Keywords: post-translational modifications, liver disease, traditional Chinese medicine