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已发表论文
植物来源外泌体样纳米颗粒：跨界调控机制及其作为疾病治疗天然药物载体的前景
Authors Liu W, Yin X , Zhang Z, Chou W, Xin Y , Zhang Y, Sun M, Zhao H, Xiao Y
Received 15 November 2025
Accepted for publication 29 January 2026
Published 3 February 2026 Volume 2026:21 581774
DOI https://doi.org/10.2147/IJN.S581774
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Dong Wang
Wei Liu,1,2,* Xiangrong Yin,3,* Zhisheng Zhang,1,2,* Wenxin Chou,4 Yexin Xin,5 Yawen Zhang,6 Mengyu Sun,3 Hongyou Zhao,4 Yilei Xiao2,6
1Postgraduate Department, Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 2Department of Neurosurgery, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, People’s Republic of China; 3School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, People’s Republic of China; 4School of Medical Technology, Beijing Institute of Technology, Beijing, People’s Republic of China; 5Department of Neurosurgery, Yidu Central Hospital of Weifang, Weifang, Shandong, People’s Republic of China; 6Neuroscience Laboratory, Liaocheng People’s Hospital, Liaocheng, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hongyou Zhao, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, People’s Republic of China, Email zhaohy@bit.edu.cn Yilei Xiao, Department of Neurosurgery, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, People’s Republic of China, Email Yileixiao@163.com
Abstract: Plant-derived exosome-like nanoparticles (PELNs) are membrane vesicles that are isolated from plant tissues, containing lipids, proteins, nucleic acids and various other natural bioactive components inside. Recent studies indicate that PELNs exhibit anti-inflammatory, antioxidant and anti-tumor functions, participate in intercellular communication and mediate cross-kingdom regulation. These nanoparticles demonstrate significant potential in the treatment of a variety of diseases, including malignancies, inflammatory bowel disease, cardiovascular disorders, and metabolic diseases. This review summarizes the biogenesis mechanisms, compositional elements and cross-kingdom regulatory functions of PELNs. Specifically, the 3′ terminal 2′-O-methylation modification of plant miRNAs ensures their structural integrity and stability under harsh physiological conditions, facilitating efficient interspecies communication. Furthermore, as natural drug carriers, PELNs have substantial advantages in the targeted delivery of small-molecule drugs, nucleic acids and functional proteins. Finally, the current challenges and future development prospects of PELNs are discussed. Although research into PELNs remains at the initial stage, their potential applications in precision medicine and drug delivery systems are promising, offering novel strategies for future disease treatment.
Keywords: plant-derived exosome-like nanoparticles, exosomes, nanomedicine, cross-kingdom regulation, therapeutic delivery
1Postgraduate Department, Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 2Department of Neurosurgery, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, People’s Republic of China; 3School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, People’s Republic of China; 4School of Medical Technology, Beijing Institute of Technology, Beijing, People’s Republic of China; 5Department of Neurosurgery, Yidu Central Hospital of Weifang, Weifang, Shandong, People’s Republic of China; 6Neuroscience Laboratory, Liaocheng People’s Hospital, Liaocheng, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hongyou Zhao, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, People’s Republic of China, Email zhaohy@bit.edu.cn Yilei Xiao, Department of Neurosurgery, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, People’s Republic of China, Email Yileixiao@163.com
Abstract: Plant-derived exosome-like nanoparticles (PELNs) are membrane vesicles that are isolated from plant tissues, containing lipids, proteins, nucleic acids and various other natural bioactive components inside. Recent studies indicate that PELNs exhibit anti-inflammatory, antioxidant and anti-tumor functions, participate in intercellular communication and mediate cross-kingdom regulation. These nanoparticles demonstrate significant potential in the treatment of a variety of diseases, including malignancies, inflammatory bowel disease, cardiovascular disorders, and metabolic diseases. This review summarizes the biogenesis mechanisms, compositional elements and cross-kingdom regulatory functions of PELNs. Specifically, the 3′ terminal 2′-O-methylation modification of plant miRNAs ensures their structural integrity and stability under harsh physiological conditions, facilitating efficient interspecies communication. Furthermore, as natural drug carriers, PELNs have substantial advantages in the targeted delivery of small-molecule drugs, nucleic acids and functional proteins. Finally, the current challenges and future development prospects of PELNs are discussed. Although research into PELNs remains at the initial stage, their potential applications in precision medicine and drug delivery systems are promising, offering novel strategies for future disease treatment.
Keywords: plant-derived exosome-like nanoparticles, exosomes, nanomedicine, cross-kingdom regulation, therapeutic delivery