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已发表论文
2 型糖尿病患者肥胖指数与糖化血红蛋白水平的相关性分析：一项横断面研究
Authors Gang P, Zhu J, Zhang B, Zhao Y, Zhao X, Luo B
Received 23 October 2025
Accepted for publication 20 January 2026
Published 3 February 2026 Volume 2026:19 575126
DOI https://doi.org/10.2147/DMSO.S575126
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Donald McClain
Pei Gang,1 Jianfeng Zhu,1 Bing Zhang,1 Yanxiao Zhao,1 Xiaowei Zhao,2 Beibei Luo3
1Department of Administration, Nanyang Second General Hospital, Nanyang, Henan Province, 473000, People’s Republic of China; 2Department of Pediatrics, Nanyang Second General Hospital, Nanyang, Henan Province, 473000, People’s Republic of China; 3Clinical Laboratory, People’s Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan Province, 653100, People’s Republic of China
Correspondence: Beibei Luo, Clinical Laboratory, People’s Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan Province, 653100, People’s Republic of China, Email bob1593650@163.com
Introduction: The global prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly. However, the relationship between obesity indexes and Glycosylated hemoglobin (HbA1c) levels remains unclear.
Methods: This cross-sectional study included 3,898 patients with T2DM who were treated in the Department of Endocrinology at Yuxi People’s Hospital between March 2018 and December 2024. Participants were grouped according to whether their HbA1c levels were below 7.0%. Linear regression analysis was performed to evaluate the associations between body mass index (BMI), visceral fat area (VFA), and waist circumference (WC) with glycosylated hemoglobin. In addition, a correlation matrix was generated.
Results: Participants with HbA1c ≥ 7.0% were slightly younger (52.9 ± 11.3 vs 53.9 ± 11.7 years, p = 0.017) and had higher BMI (25.4 ± 3.6 vs 25.1 ± 3.5 kg/m2, p = 0.037), WC (88.9 ± 9.5 vs 88.1 ± 8.8 cm, p = 0.021), and VFA (88.2 ± 39.4 vs 85.1 ± 36.6 cm2, p = 0.029) than those with HbA1c < 7.0%. However, no statistically significant associations were observed between HbA1c and BMI (β = – 0.0029, 95% CI: – 0.0243 to 0.0185, p = 0.79), WC (β = – 0.0037, 95% CI: – 0.012 to 0.0047, p = 0.38), or VFA (β = – 0.0012, 95% CI: – 0.0032 to 0.0008, p = 0.24).
Conclusion: There was no significant correlation between obesity indexes and HbA1c levels among patients with T2DM.
Keywords: BMI, HbA1c, T2DM
1Department of Administration, Nanyang Second General Hospital, Nanyang, Henan Province, 473000, People’s Republic of China; 2Department of Pediatrics, Nanyang Second General Hospital, Nanyang, Henan Province, 473000, People’s Republic of China; 3Clinical Laboratory, People’s Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan Province, 653100, People’s Republic of China
Correspondence: Beibei Luo, Clinical Laboratory, People’s Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan Province, 653100, People’s Republic of China, Email bob1593650@163.com
Introduction: The global prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly. However, the relationship between obesity indexes and Glycosylated hemoglobin (HbA1c) levels remains unclear.
Methods: This cross-sectional study included 3,898 patients with T2DM who were treated in the Department of Endocrinology at Yuxi People’s Hospital between March 2018 and December 2024. Participants were grouped according to whether their HbA1c levels were below 7.0%. Linear regression analysis was performed to evaluate the associations between body mass index (BMI), visceral fat area (VFA), and waist circumference (WC) with glycosylated hemoglobin. In addition, a correlation matrix was generated.
Results: Participants with HbA1c ≥ 7.0% were slightly younger (52.9 ± 11.3 vs 53.9 ± 11.7 years, p = 0.017) and had higher BMI (25.4 ± 3.6 vs 25.1 ± 3.5 kg/m2, p = 0.037), WC (88.9 ± 9.5 vs 88.1 ± 8.8 cm, p = 0.021), and VFA (88.2 ± 39.4 vs 85.1 ± 36.6 cm2, p = 0.029) than those with HbA1c < 7.0%. However, no statistically significant associations were observed between HbA1c and BMI (β = – 0.0029, 95% CI: – 0.0243 to 0.0185, p = 0.79), WC (β = – 0.0037, 95% CI: – 0.012 to 0.0047, p = 0.38), or VFA (β = – 0.0012, 95% CI: – 0.0032 to 0.0008, p = 0.24).
Conclusion: There was no significant correlation between obesity indexes and HbA1c levels among patients with T2DM.
Keywords: BMI, HbA1c, T2DM