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已发表论文
血尿素氮/白蛋白比值与 2 型糖尿病患者糖尿病周围神经病变相关
Authors Pan B, Zhao J, Xu J , Zhang H
Received 30 November 2025
Accepted for publication 27 January 2026
Published 3 February 2026 Volume 2026:19 585533
DOI https://doi.org/10.2147/DMSO.S585533
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Bilin Pan,1,* Jianyong Zhao,2,* Jing Xu,1 Hengyiting Zhang3
1Department of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, Chaohu, People’s Republic of China; 3Department of Interventional Therapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hengyiting Zhang, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, People’s Republic of China, Email 361766711@qq.com
Purpose: Blood urea nitrogen (BUN) to albumin ratio (BAR) serves as a multifaceted parameter indicative of inflammatory, renal, endothelial, and nutritional functions. Previous studies have demonstrated that an elevated BAR is a valuable biomarker with predictive significance in various diseases. Nonetheless, the association between BAR and diabetic peripheral neuropathy (DPN) has not been previously documented. This study seeks to explore the potential association between BAR and DPN in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods: A total of 3239 patients diagnosed with T2DM admitted to the Second Affiliated Hospital of Wenzhou Medical University from 2018 to 2023 were included in this cross-sectional study. The analysis was conducted through logistic regression and restricted cubic spline (RCS) methodologies, complemented by additional stratified and interaction analyses.
Results: As the quartiles of BAR increased, there was a notable increase in the prevalence of DPN, with the rates of 13.3%, 19.4%, 26.0%, and 38.3%, respectively. Logistic regression analysis showed a positive association between BAR and DPN (OR=1.20, 95% CI: 1.12– 1.28), which was consistently observed across all subgroups through stratified analysis. RCS analysis identified a linear association, without saturation effects. Additionally, AUC for BAR (AUC = 0.660, 95% CI: 0.639– 0.683) was significantly higher compared to those of BUN and albumin alone.
Conclusion: BAR exhibits a positive association with the risk of DPN, underscoring its potential utility as a cost-effective biomarker for stratifying the risk of DPN.
Keywords: BUN, albumin, DPN, T2DM, inflammation
1Department of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Endocrinology, The Fourth Affiliated Hospital of Anhui Medical University, Chaohu, People’s Republic of China; 3Department of Interventional Therapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hengyiting Zhang, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, People’s Republic of China, Email 361766711@qq.com
Purpose: Blood urea nitrogen (BUN) to albumin ratio (BAR) serves as a multifaceted parameter indicative of inflammatory, renal, endothelial, and nutritional functions. Previous studies have demonstrated that an elevated BAR is a valuable biomarker with predictive significance in various diseases. Nonetheless, the association between BAR and diabetic peripheral neuropathy (DPN) has not been previously documented. This study seeks to explore the potential association between BAR and DPN in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods: A total of 3239 patients diagnosed with T2DM admitted to the Second Affiliated Hospital of Wenzhou Medical University from 2018 to 2023 were included in this cross-sectional study. The analysis was conducted through logistic regression and restricted cubic spline (RCS) methodologies, complemented by additional stratified and interaction analyses.
Results: As the quartiles of BAR increased, there was a notable increase in the prevalence of DPN, with the rates of 13.3%, 19.4%, 26.0%, and 38.3%, respectively. Logistic regression analysis showed a positive association between BAR and DPN (OR=1.20, 95% CI: 1.12– 1.28), which was consistently observed across all subgroups through stratified analysis. RCS analysis identified a linear association, without saturation effects. Additionally, AUC for BAR (AUC = 0.660, 95% CI: 0.639– 0.683) was significantly higher compared to those of BUN and albumin alone.
Conclusion: BAR exhibits a positive association with the risk of DPN, underscoring its potential utility as a cost-effective biomarker for stratifying the risk of DPN.
Keywords: BUN, albumin, DPN, T2DM, inflammation