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已发表论文
中西医结合治疗慢性子宫内膜炎合并反复种植失败后自然受孕：一例病例报告及文献综述
Authors Jin Y , Shen T, Hong R, Yu X, Liang Y , Jin B
Received 17 November 2025
Accepted for publication 26 January 2026
Published 4 February 2026 Volume 2026:19 579367
DOI https://doi.org/10.2147/IDR.S579367
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Hazrat Bilal
Yihan Jin,1,2 Tao Shen,1 Renyun Hong,1 Xiaoxiao Yu,1 Yuanjiao Liang,1 Baofang Jin3
1Reproductive Medicine Center, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, People’s Republic of China; 2Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People’s Republic of China; 3External Medicine in Chinese Medicine Department, The Chinese Medicine Hospital of Hong Kong, Hong Kong, People’s Republic of China
Correspondence: Baofang Jin, Email hexiking@126.com
Abstract: Recurrent implantation failure (RIF) is a challenging issue in in vitro fertilization and embryo transfer (IVF-ET). Chronic endometritis (CE) is one of the causes of RIF. For patients with CE and RIF, antibiotic therapy is currently the first-line and most widely used treatment. Nevertheless, it often fails to achieve the desired therapeutic outcomes. This case report presents a woman diagnosed with CE and RIF, who did not achieve pregnancy after four embryo transfers involving a total of seven embryos during IVF-ET treatment. However, after receiving a integrated therapy of Traditional Chinese Medicine (TCM) and antibiotics for CE, the patient achieved a spontaneous conception and subsequently delivered a healthy baby. This case suggests that an integrated approach of TCM and antibiotics may represent a safe and effective therapeutic strategy for patients with CE and RIF, offering a potential alternative to overcome the limitations of conventional antibiotic therapy alone. This finding warrants further investigation.
Keywords: chronic endometritis, recurrent implantation failure, endometrial receptivity, integrative Chinese and Western medicine therapy
1Reproductive Medicine Center, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, People’s Republic of China; 2Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People’s Republic of China; 3External Medicine in Chinese Medicine Department, The Chinese Medicine Hospital of Hong Kong, Hong Kong, People’s Republic of China
Correspondence: Baofang Jin, Email hexiking@126.com
Abstract: Recurrent implantation failure (RIF) is a challenging issue in in vitro fertilization and embryo transfer (IVF-ET). Chronic endometritis (CE) is one of the causes of RIF. For patients with CE and RIF, antibiotic therapy is currently the first-line and most widely used treatment. Nevertheless, it often fails to achieve the desired therapeutic outcomes. This case report presents a woman diagnosed with CE and RIF, who did not achieve pregnancy after four embryo transfers involving a total of seven embryos during IVF-ET treatment. However, after receiving a integrated therapy of Traditional Chinese Medicine (TCM) and antibiotics for CE, the patient achieved a spontaneous conception and subsequently delivered a healthy baby. This case suggests that an integrated approach of TCM and antibiotics may represent a safe and effective therapeutic strategy for patients with CE and RIF, offering a potential alternative to overcome the limitations of conventional antibiotic therapy alone. This finding warrants further investigation.
Keywords: chronic endometritis, recurrent implantation failure, endometrial receptivity, integrative Chinese and Western medicine therapy