120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
生殖道畸形的临床特征：一项关于其与子宫内膜异位症及妊娠结局关联的回顾性队列研究
Authors Wang Y, Chen R, Wang J, Huang B, Zhou H
Received 12 May 2025
Accepted for publication 14 January 2026
Published 4 February 2026 Volume 2026:18 536956
DOI https://doi.org/10.2147/IJWH.S536956
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Yan Wang,1,* Ruilin Chen,1,* Junnan Wang,1 Bingna Huang,1 Huaijun Zhou1,2
1Department of Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Department of Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huaijun Zhou, Email zhouhj2007@126.com
Purpose: To characterize the clinical phenotypes of congenital genital tract malformations and evaluate their associations with endometriosis (EM) and fertility outcomes.
Patients and Methods: This retrospective cohort study analyzed 306 women with congenital genital tract anomalies treated at a tertiary hospital (2011– 2022). Anatomical classifications (obstructive vs non-obstructive), laparoscopically confirmed EM, and postoperative fertility were assessed. Infertility was defined as failure to achieve a clinical pregnancy after ≥ 12 months of unprotected intercourse.
Results: The overall EM prevalence was 18.3% (56/306), which was significantly higher in the obstructive group than in the non-obstructive group (42.86% vs 16.49%, P=0.006). Patients with obstructive malformations developed EM at a younger age (25.22± 4.02 vs 28.46± 4.49 years, P=0.049) and had more severe EM stages (P=0.027). Preoperative infertility rates were comparable between the obstructive (38.10%) and non-obstructive (36.84%) groups (P=1.0). However, within the non-obstructive group, the infertility rate was significantly higher in women with EM than in those without (53.32% vs 33.19%, P=0.004). Surgical intervention significantly reduced infertility rates, with the most substantial benefit observed in the non-obstructive malformation + EM subgroup (Absolute Risk Reduction=48.94%, Number Needed to Treat=2). Vaginal septa and residual uterine horns were associated with the highest infertility risks.
Conclusion: Obstructive malformations are associated with early-onset, severe EM, likely facilitated by retrograde menstruation. Non-obstructive variants are linked to insidious EM progression and diagnostic delay. Timely surgical correction, particularly for septal anomalies, significantly improves fertility. Integrating MRI into diagnostic protocols and maintaining a high index of suspicion for occult malformations in adolescents with EM are crucial.
Keywords: endometriosis, genital tract malformations, infertility, vaginal septum, uterine septum, pregnancy outcomes
1Department of Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Department of Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huaijun Zhou, Email zhouhj2007@126.com
Purpose: To characterize the clinical phenotypes of congenital genital tract malformations and evaluate their associations with endometriosis (EM) and fertility outcomes.
Patients and Methods: This retrospective cohort study analyzed 306 women with congenital genital tract anomalies treated at a tertiary hospital (2011– 2022). Anatomical classifications (obstructive vs non-obstructive), laparoscopically confirmed EM, and postoperative fertility were assessed. Infertility was defined as failure to achieve a clinical pregnancy after ≥ 12 months of unprotected intercourse.
Results: The overall EM prevalence was 18.3% (56/306), which was significantly higher in the obstructive group than in the non-obstructive group (42.86% vs 16.49%, P=0.006). Patients with obstructive malformations developed EM at a younger age (25.22± 4.02 vs 28.46± 4.49 years, P=0.049) and had more severe EM stages (P=0.027). Preoperative infertility rates were comparable between the obstructive (38.10%) and non-obstructive (36.84%) groups (P=1.0). However, within the non-obstructive group, the infertility rate was significantly higher in women with EM than in those without (53.32% vs 33.19%, P=0.004). Surgical intervention significantly reduced infertility rates, with the most substantial benefit observed in the non-obstructive malformation + EM subgroup (Absolute Risk Reduction=48.94%, Number Needed to Treat=2). Vaginal septa and residual uterine horns were associated with the highest infertility risks.
Conclusion: Obstructive malformations are associated with early-onset, severe EM, likely facilitated by retrograde menstruation. Non-obstructive variants are linked to insidious EM progression and diagnostic delay. Timely surgical correction, particularly for septal anomalies, significantly improves fertility. Integrating MRI into diagnostic protocols and maintaining a high index of suspicion for occult malformations in adolescents with EM are crucial.
Keywords: endometriosis, genital tract malformations, infertility, vaginal septum, uterine septum, pregnancy outcomes