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已发表论文
2010 至 2025 年动脉粥样硬化研究中 CircRNA 的知识图谱：聚焦脂质代谢、焦亡和外泌体
Authors Wu K, He S, Shen Y, Li J, Li B, Chen G, Lei Y, Chen G , Li Q, Li M
Received 19 November 2025
Accepted for publication 7 January 2026
Published 4 February 2026 Volume 2026:19 580929
DOI https://doi.org/10.2147/JIR.S580929
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Chengming Fan
Kunjun Wu,1,2,* Shipei He,1,* Yuyan Shen,1,3 Jiandi Li,1 Bin Li,1 Guoqiang Chen,1 Yixun Lei,1,2 Gang Chen,1 Qi Li,1,* Mingjie Li1,2,*
1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 2Department of Forensic Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 3School of Foreign Languages, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Mingjie Li, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China, Email limingjie@stu.gxmu.edu.cn
Background: Atherosclerosis (AS) is the leading cause of death from cardiovascular disease worldwide, involving complex inflammatory, molecular and cellular pathways as well as intercellular cross-talk. CircRNAs are highly stable, circular non-coding RNAs that function by acting as miRNA sponges, regulating transcription, and influencing protein translation. In AS research, CircRNAs have turned the spotlight onto a promising new target with significant therapeutic potential. This study aimed to elucidate academic landscape, reveal active topics and future research focus of CircRNAs in AS research.
Methods: Publications on CircRNAs in AS research were retrieved from Web of Science Core Collection (WoSCC). The bibliometric tools, including R, VOSviewer and Citespace, were used to conduct a scientometric analysis of 225 relevant studies.
Results: This study identifies China as the primary research nations in the field of CircRNAs in AS research. However, attention must still be paid to the striking imbalance between productivity and deserved impact. The majority of current research is conducted using in vitro models. However, in vivo experiments are urgently needed to provide additional evidence for the inconclusive results obtained in vitro. The lipid infiltration theory, particularly the role of CircRNAs in regulating macrophage cholesterol efflux, has become a new research entry point for the treatment of AS. In addition, this study also identified pyroptosis and exosomes as future research focus in the field of CircRNAs in AS research.
Conclusion: This bibliometric analysis synthesises the extensive evidence on CircRNAs in AS research and provides insights to guide future scientific work in this field.
Keywords: atherosclerosis, CircRNA, bibliometric, pyroptosis, exosomes
1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 2Department of Forensic Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 3School of Foreign Languages, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Mingjie Li, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China, Email limingjie@stu.gxmu.edu.cn
Background: Atherosclerosis (AS) is the leading cause of death from cardiovascular disease worldwide, involving complex inflammatory, molecular and cellular pathways as well as intercellular cross-talk. CircRNAs are highly stable, circular non-coding RNAs that function by acting as miRNA sponges, regulating transcription, and influencing protein translation. In AS research, CircRNAs have turned the spotlight onto a promising new target with significant therapeutic potential. This study aimed to elucidate academic landscape, reveal active topics and future research focus of CircRNAs in AS research.
Methods: Publications on CircRNAs in AS research were retrieved from Web of Science Core Collection (WoSCC). The bibliometric tools, including R, VOSviewer and Citespace, were used to conduct a scientometric analysis of 225 relevant studies.
Results: This study identifies China as the primary research nations in the field of CircRNAs in AS research. However, attention must still be paid to the striking imbalance between productivity and deserved impact. The majority of current research is conducted using in vitro models. However, in vivo experiments are urgently needed to provide additional evidence for the inconclusive results obtained in vitro. The lipid infiltration theory, particularly the role of CircRNAs in regulating macrophage cholesterol efflux, has become a new research entry point for the treatment of AS. In addition, this study also identified pyroptosis and exosomes as future research focus in the field of CircRNAs in AS research.
Conclusion: This bibliometric analysis synthesises the extensive evidence on CircRNAs in AS research and provides insights to guide future scientific work in this field.
Keywords: atherosclerosis, CircRNA, bibliometric, pyroptosis, exosomes