120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
治疗师指导的互联网正念认知疗法治疗慢性失眠障碍的疗效：一项随机对照试验
Authors Zeng Z , Jiang J, Xie K, Luo N, Guan X, Zhu C, Lu Z, Huang L
Received 13 November 2025
Accepted for publication 16 January 2026
Published 4 February 2026 Volume 2026:18 578770
DOI https://doi.org/10.2147/NSS.S578770
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Prof. Dr. Ahmed BaHammam
Zixuan Zeng,1,2,* Jiahui Jiang,1,2,* Kun Xie,3 Na Luo,1 Xiaofeng Guan,2 Chenyi Zhu,1 Zheng Lu,2 Lei Huang2
1School of Medicine, Tongji University, Shanghai, 200331, People’s Republic of China; 2Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 3Mental Health Education and Counseling Center, University of Shanghai for Science and Technology, Shanghai, 200093, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zheng Lu, Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China, Email luzheng@tongji.edu.cn Lei Huang, Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China, Email huanglei@tongji.edu.cn
Purpose: Chronic Insomnia Disorder (CID) is prevalent, yet access to effective treatments is limited. Integrating mindfulness with Cognitive Behavioral Therapy for Insomnia (CBT-I) in an accessible online format may fill this gap. This study evaluated the efficacy of a therapist-guided, internet-delivered Mindfulness-Based Cognitive Therapy for Insomnia (iMBCT-I), which has been scarcely investigated.
Patients and Methods: In this open-label, parallel-group randomized trial, 82 participants with CID were assigned to the 8-week of iMBCT-I group (n = 41) or a control group receiving a single online session of sleep hygiene education (SHE, n = 41). The primary outcomes were insomnia severity assessed with Insomnia Severity Index (ISI) and insomnia remission (ISI < 8) rate. Secondary outcomes included sleep quality, sleep diary and actigraphy parameters, depressive and anxious symptoms, and quality of life. The primary and the follow-up time-points were week 8 and week 20, respectively. Statistical analyses followed the intention-to-treat principle.
Results: No serious adverse events were reported. At week 8, the ISI score in the iMBCT-I group showed a significant decrease compared to the SHE group [mean difference, 95% confidence intervals (CI) = 4.00 (2.22, 5.78), p < 0.001, Cohen’s d, 95% CI = 0.99 (0.53, 1.45)]. More participants achieved insomnia remission in the iMBCT-I group [odds ratio, 95% CI = 6.21 (2.24, 17.23), p < 0.001]. The iMBCT-I was also superior on improving sleep quality, sleep onset latency, wakefulness after sleep onset, sleep efficiency, rapid eye movement duration, depressive symptoms and both physical and mental quality of life (all p < 0.05). Linear mixed-effects model showed the maintenance of these effects at the 20-week follow-up for most outcomes.
Conclusion: Therapist-guided iMBCT-I is effective in reducing insomnia severity in adults with CID with benefits sustained for 20 weeks.
Trial Registration: This study has been registered with the Chinese Clinical Trial Registry https://www.chictr.org.cn/ (Registration Number: ChiCTR2400084300).
Keywords: cognitive behavioral therapy, insomnia, mindfulness, randomized controlled trial
1School of Medicine, Tongji University, Shanghai, 200331, People’s Republic of China; 2Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 3Mental Health Education and Counseling Center, University of Shanghai for Science and Technology, Shanghai, 200093, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zheng Lu, Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China, Email luzheng@tongji.edu.cn Lei Huang, Department of Psychiatry, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China, Email huanglei@tongji.edu.cn
Purpose: Chronic Insomnia Disorder (CID) is prevalent, yet access to effective treatments is limited. Integrating mindfulness with Cognitive Behavioral Therapy for Insomnia (CBT-I) in an accessible online format may fill this gap. This study evaluated the efficacy of a therapist-guided, internet-delivered Mindfulness-Based Cognitive Therapy for Insomnia (iMBCT-I), which has been scarcely investigated.
Patients and Methods: In this open-label, parallel-group randomized trial, 82 participants with CID were assigned to the 8-week of iMBCT-I group (n = 41) or a control group receiving a single online session of sleep hygiene education (SHE, n = 41). The primary outcomes were insomnia severity assessed with Insomnia Severity Index (ISI) and insomnia remission (ISI < 8) rate. Secondary outcomes included sleep quality, sleep diary and actigraphy parameters, depressive and anxious symptoms, and quality of life. The primary and the follow-up time-points were week 8 and week 20, respectively. Statistical analyses followed the intention-to-treat principle.
Results: No serious adverse events were reported. At week 8, the ISI score in the iMBCT-I group showed a significant decrease compared to the SHE group [mean difference, 95% confidence intervals (CI) = 4.00 (2.22, 5.78), p < 0.001, Cohen’s d, 95% CI = 0.99 (0.53, 1.45)]. More participants achieved insomnia remission in the iMBCT-I group [odds ratio, 95% CI = 6.21 (2.24, 17.23), p < 0.001]. The iMBCT-I was also superior on improving sleep quality, sleep onset latency, wakefulness after sleep onset, sleep efficiency, rapid eye movement duration, depressive symptoms and both physical and mental quality of life (all p < 0.05). Linear mixed-effects model showed the maintenance of these effects at the 20-week follow-up for most outcomes.
Conclusion: Therapist-guided iMBCT-I is effective in reducing insomnia severity in adults with CID with benefits sustained for 20 weeks.
Trial Registration: This study has been registered with the Chinese Clinical Trial Registry https://www.chictr.org.cn/ (Registration Number: ChiCTR2400084300).
Keywords: cognitive behavioral therapy, insomnia, mindfulness, randomized controlled trial