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已发表论文
伴鼻息肉慢性鼻窦炎中上皮下纤维化与维生素 D 缺乏的相关性：来自组织学和转录组分析的见解
Authors Chi M, Wang K, Bi M, Yang Z, Xing Y , Fan Y
Received 9 October 2025
Accepted for publication 24 January 2026
Published 5 February 2026 Volume 2026:19 570759
DOI https://doi.org/10.2147/JIR.S570759
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Tara Strutt
Mengshi Chi,1,* Kanghua Wang,1,* Mingmin Bi,1 Zheng Yang,2 Yuhan Xing,3 Yunping Fan1
1Department of Otorhinolaryngology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People’s Republic of China; 2Department of Pathology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People’s Republic of China; 3School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yunping Fan, Department of Otorhinolaryngology, The Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628, Zhenyuan Road, Guangming (New) District, Shenzhen, Guangdong, 518107, People’s Republic of China, Tel +0755-81206892, Email zhfanyp@163.com; fanyp@mail.sysu.edu.cn Yuhan Xing, School of Public Health (Shenzhen), Sun Yat- Sen University, No. 66 Gongchang Road, Guangming District, Shenzhen, 518107, People’s Republic of China, Email xingyh8@mail.sysu.edu.cn
Purpose: To investigate the correlation between serum vitamin D status and clinical, histological, and gene expression profiles in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Patients and Methods: This observational study enrolled patients with CRSwNP from November 2019 to September 2021, and diagnoses were confirmed according to the 2020 European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS 2020). Clinical features, histopathological characteristics, and gene expression profiles were analyzed across groups with serum vitamin D deficiency status. Histopathological evaluations and mRNA sequencing were performed on a subset of nasal polyp specimens.
Results: Among 101 patients with CRSwNP, a comprehensive analysis revealed no significant correlation between vitamin D deficiency and most clinical parameters or treatment prognosis, except for a notable age difference among groups with serum vitamin D-deficiency, insufficiency, and sufficiency. Histologically, a higher prevalence of subepithelial fibrosis was observed in the vitamin D-deficient group. Moreover, transcriptomic analysis demonstrated significant differences in expression profiles among the groups, with upregulated genes in the deficient group enriched in extracellular matrix components and downregulated genes related to axoneme assembly and cilium movement.
Conclusion: Our findings suggest a connection between vitamin D deficiency and subepithelial fibrosis in nasal polyps, pointing to a possible involvement of vitamin D status in fibrosis-related pathological processes in CRSwNP.
Keywords: chronic rhinosinusitis, nasal polyps, vitamin D deficiency, tissue fibrosis, transcriptomic profiles
1Department of Otorhinolaryngology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People’s Republic of China; 2Department of Pathology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People’s Republic of China; 3School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yunping Fan, Department of Otorhinolaryngology, The Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628, Zhenyuan Road, Guangming (New) District, Shenzhen, Guangdong, 518107, People’s Republic of China, Tel +0755-81206892, Email zhfanyp@163.com; fanyp@mail.sysu.edu.cn Yuhan Xing, School of Public Health (Shenzhen), Sun Yat- Sen University, No. 66 Gongchang Road, Guangming District, Shenzhen, 518107, People’s Republic of China, Email xingyh8@mail.sysu.edu.cn
Purpose: To investigate the correlation between serum vitamin D status and clinical, histological, and gene expression profiles in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Patients and Methods: This observational study enrolled patients with CRSwNP from November 2019 to September 2021, and diagnoses were confirmed according to the 2020 European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS 2020). Clinical features, histopathological characteristics, and gene expression profiles were analyzed across groups with serum vitamin D deficiency status. Histopathological evaluations and mRNA sequencing were performed on a subset of nasal polyp specimens.
Results: Among 101 patients with CRSwNP, a comprehensive analysis revealed no significant correlation between vitamin D deficiency and most clinical parameters or treatment prognosis, except for a notable age difference among groups with serum vitamin D-deficiency, insufficiency, and sufficiency. Histologically, a higher prevalence of subepithelial fibrosis was observed in the vitamin D-deficient group. Moreover, transcriptomic analysis demonstrated significant differences in expression profiles among the groups, with upregulated genes in the deficient group enriched in extracellular matrix components and downregulated genes related to axoneme assembly and cilium movement.
Conclusion: Our findings suggest a connection between vitamin D deficiency and subepithelial fibrosis in nasal polyps, pointing to a possible involvement of vitamin D status in fibrosis-related pathological processes in CRSwNP.
Keywords: chronic rhinosinusitis, nasal polyps, vitamin D deficiency, tissue fibrosis, transcriptomic profiles