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已发表论文
低湿度改变体内表皮基因表达
Authors Wen S, Wang X, Ye L , Gong C, Liu D, Man MQ
Received 27 November 2025
Accepted for publication 29 January 2026
Published 4 February 2026 Volume 2026:19 577853
DOI https://doi.org/10.2147/CCID.S577853
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Anne-Claire Fougerousse
Si Wen,1 Xiaohua Wang,2 Li Ye,1 Canyi Gong,3 Dan Liu,3 Mao-Qiang Man3,4
1Evaluation Center for Skin Care Product Efficacy, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People’s Republic of China; 2Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People’s Republic of China; 3Formulation Center, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People’s Republic of China; 4Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050023, People’s Republic of China
Correspondence: Mao-Qiang Man, Formulation center, Dermatology Hospital of Southern Medical University, 2 Lujing Road, Guangzhou, 510091, People’s Republic of China, Email mqman@hotmail.com
Introduction: Environmental factors, including humidity, affect cutaneous functions. The influences of low humidity on epidermal gene expression and whether an emollient can attenuate its effects are unknown.
Methods: We employed RNAseq technique to analyze epidermal gene expression in mice exposed to low humidity (15%) with or without topical treatment with an emollient (Dr. Yu Skin Barrier Repair Cream®) for 6 months. Mice maintained in normal humidity (55± 5%) served as normal controls.
Results: Exposure of mice to low humidity down-regulated 159 genes and upregulated 105 genes in the epidermis. Topical applications of the emollient upregulated 195 genes and downregulated 280 genes in mice exposed to low humidity. Low humidity primarily downregulated genes associated with interaction between viral proteins and cytokines, and cytokine-cytokine interaction pathways, while upregulating genes associated with IL-17 and TNF signaling pathways. Topical emollient upregulated signaling pathways associated with fatty acid elongation, peroxisome proliferator-activated receptors (PPAR) and fatty acid metabolism in mice exposed to low humidity, while down-regulated genes were associated with inflammation.
Conclusion: These results demonstrate that low humidity alters epidermal gene expression, and topical emollient regulates epidermal gene expression in mice exposed to low humidity, providing a rationale for utility of emollients in low-humidity environment and the management of dry skin.
Keywords: environment, humidity, epidermis, emollient, RNA sequencing, cytokines
1Evaluation Center for Skin Care Product Efficacy, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People’s Republic of China; 2Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People’s Republic of China; 3Formulation Center, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People’s Republic of China; 4Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050023, People’s Republic of China
Correspondence: Mao-Qiang Man, Formulation center, Dermatology Hospital of Southern Medical University, 2 Lujing Road, Guangzhou, 510091, People’s Republic of China, Email mqman@hotmail.com
Introduction: Environmental factors, including humidity, affect cutaneous functions. The influences of low humidity on epidermal gene expression and whether an emollient can attenuate its effects are unknown.
Methods: We employed RNAseq technique to analyze epidermal gene expression in mice exposed to low humidity (15%) with or without topical treatment with an emollient (Dr. Yu Skin Barrier Repair Cream®) for 6 months. Mice maintained in normal humidity (55± 5%) served as normal controls.
Results: Exposure of mice to low humidity down-regulated 159 genes and upregulated 105 genes in the epidermis. Topical applications of the emollient upregulated 195 genes and downregulated 280 genes in mice exposed to low humidity. Low humidity primarily downregulated genes associated with interaction between viral proteins and cytokines, and cytokine-cytokine interaction pathways, while upregulating genes associated with IL-17 and TNF signaling pathways. Topical emollient upregulated signaling pathways associated with fatty acid elongation, peroxisome proliferator-activated receptors (PPAR) and fatty acid metabolism in mice exposed to low humidity, while down-regulated genes were associated with inflammation.
Conclusion: These results demonstrate that low humidity alters epidermal gene expression, and topical emollient regulates epidermal gene expression in mice exposed to low humidity, providing a rationale for utility of emollients in low-humidity environment and the management of dry skin.
Keywords: environment, humidity, epidermis, emollient, RNA sequencing, cytokines