120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
通过在 CoFe2O4 上原子层沉积金构建双刺激响应纳米平台，用于结直肠癌热控阿霉素递送
Authors Zhang Y, Liu L, Wang T, Qu Z, Liang L, Li H, Wang H
Received 28 August 2025
Accepted for publication 10 December 2025
Published 4 February 2026 Volume 2026:21 563711
DOI https://doi.org/10.2147/IJN.S563711
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Yan Shen
Yutian Zhang,1,* Lang Liu,2,* Tianlin Wang,3 Ziyi Qu,4 Lei Liang,1 Huizhen Li,3 Hong Wang5
1Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300100, People’s Republic of China; 2College of Meteorology and Oceanography, National University of Defense Technology, Changsha, Hunan, 410073, People’s Republic of China; 3Department of Gastroenterology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300100, People’s Republic of China; 4Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, People’s Republic of China; 5Department of General Surgery, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300100, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huizhen Li, Email ctjenny@126.com Hong Wang, Email ctwanghong@sina.com
Introduction: Targeted chemotherapy for colorectal cancer is often limited by nonspecific drug distribution and systemic toxicity. To improve local therapeutic efficacy and reduce side effects, we designed a thermally gated, dual-stimuli-responsive nanoplatform for controlled doxorubicin (DOX) delivery.
Methods: CoFe2O4 (CFO) nanocubes were synthesized and coated with Au nanoparticles via atomic layer deposition (ALD) to obtain CFO/Au nanocomposites with enhanced photothermal properties while retaining magnetic responsiveness. The optimal sample (CFO/Au-2) was further modified with poly(acrylic acid) (PAA) to improve aqueous dispersibility and provide abundant carboxyl groups for DOX loading, yielding CFO/Au-2/PAA/DOX. A thermal gate was then constructed using 1-tetradecanol (TD), a phase-change material with a melting point of ~38 °C, to obtain CFO/Au-2/PAA/DOX/TD. The structural, magnetic, and photothermal properties, DOX loading and release behavior, and in vitro cytotoxicity against SW620 colorectal cancer cells were systematically evaluated under near-infrared (NIR) irradiation and/or alternating magnetic field (AMF).
Results: CFO/Au-2/PAA/DOX/TD exhibited a high DOX loading capacity (~26 wt%) and good colloidal stability. Minimal DOX leakage occurred at physiological temperature, confirming effective encapsulation by solid TD. Under NIR and/or AMF stimulation, the nanocomposite generated pronounced local heating, induced TD melting, and triggered rapid DOX release, with the combined NIR + AMF condition producing the fastest release profile. In vitro, the carrier without DOX showed minimal cytotoxicity toward SW620 cells, whereas CFO/Au-2/PAA/DOX/TD under dual stimulation produced significantly enhanced cytotoxicity toward SW620 cells compared with free DOX at the same drug concentration.
Conclusion: This ALD-engineered CFO/Au-2/PAA/DOX/TD nanoplatform integrates magnetic and photothermal heating with thermally gated, dual-stimuli-responsive drug release, enabling precise spatiotemporal control of DOX delivery. The results suggest strong potential for combined and localized colorectal cancer therapy with reduced systemic toxicity.
Keywords: colorectal cancer, CoFe2O4 nanocubes, atomic layer deposition, doxorubicin delivery, photothermal therapy, phase-change material
1Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300100, People’s Republic of China; 2College of Meteorology and Oceanography, National University of Defense Technology, Changsha, Hunan, 410073, People’s Republic of China; 3Department of Gastroenterology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300100, People’s Republic of China; 4Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, People’s Republic of China; 5Department of General Surgery, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300100, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huizhen Li, Email ctjenny@126.com Hong Wang, Email ctwanghong@sina.com
Introduction: Targeted chemotherapy for colorectal cancer is often limited by nonspecific drug distribution and systemic toxicity. To improve local therapeutic efficacy and reduce side effects, we designed a thermally gated, dual-stimuli-responsive nanoplatform for controlled doxorubicin (DOX) delivery.
Methods: CoFe2O4 (CFO) nanocubes were synthesized and coated with Au nanoparticles via atomic layer deposition (ALD) to obtain CFO/Au nanocomposites with enhanced photothermal properties while retaining magnetic responsiveness. The optimal sample (CFO/Au-2) was further modified with poly(acrylic acid) (PAA) to improve aqueous dispersibility and provide abundant carboxyl groups for DOX loading, yielding CFO/Au-2/PAA/DOX. A thermal gate was then constructed using 1-tetradecanol (TD), a phase-change material with a melting point of ~38 °C, to obtain CFO/Au-2/PAA/DOX/TD. The structural, magnetic, and photothermal properties, DOX loading and release behavior, and in vitro cytotoxicity against SW620 colorectal cancer cells were systematically evaluated under near-infrared (NIR) irradiation and/or alternating magnetic field (AMF).
Results: CFO/Au-2/PAA/DOX/TD exhibited a high DOX loading capacity (~26 wt%) and good colloidal stability. Minimal DOX leakage occurred at physiological temperature, confirming effective encapsulation by solid TD. Under NIR and/or AMF stimulation, the nanocomposite generated pronounced local heating, induced TD melting, and triggered rapid DOX release, with the combined NIR + AMF condition producing the fastest release profile. In vitro, the carrier without DOX showed minimal cytotoxicity toward SW620 cells, whereas CFO/Au-2/PAA/DOX/TD under dual stimulation produced significantly enhanced cytotoxicity toward SW620 cells compared with free DOX at the same drug concentration.
Conclusion: This ALD-engineered CFO/Au-2/PAA/DOX/TD nanoplatform integrates magnetic and photothermal heating with thermally gated, dual-stimuli-responsive drug release, enabling precise spatiotemporal control of DOX delivery. The results suggest strong potential for combined and localized colorectal cancer therapy with reduced systemic toxicity.
Keywords: colorectal cancer, CoFe2O4 nanocubes, atomic layer deposition, doxorubicin delivery, photothermal therapy, phase-change material