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已发表论文
PCOS 管理的演变：从症状控制到表型靶向治疗
Authors Wang T, Zhang T, Wang J, Lu T
Received 29 August 2025
Accepted for publication 12 January 2026
Published 4 February 2026 Volume 2026:19 560296
DOI https://doi.org/10.2147/DMSO.S560296
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Melissa Olfert
Tong Wang,1 Tianhong Zhang,2 Jingyuan Wang,1 Tao Lu2
1Department of Reproduction, Qingdao Municipal Hospital, Qingdao, 266071, People’s Republic of China; 2Department of Gynecology, Qingdao Municipal Hospital, Qingdao, 266071, People’s Republic of China
Correspondence: Tao Lu, Email taoluanthony@126.com Jingyuan Wang, Email jingyuan_wangqd09@163.com
Abstract: Polycystic ovary syndrome (PCOS) constitutes a prevalent endocrine and metabolic disorder that substantially compromises reproductive and metabolic health in women of reproductive age. The escalating global prevalence of this multisystem condition underscores the need for innovative, interdisciplinary management strategies. Unlike existing reviews, this paper offers a distinctive synthesis of recent advances in PCOS clinical management, with a novel focus on integrating lifestyle modifications, pharmacological interventions, assisted reproductive techniques, and emerging therapeutic approaches such as digital health tools and personalized medicine. It critically evaluates the mechanisms, efficacy, and limitations of these strategies, while identifying underexplored gaps in current knowledge and practice. Furthermore, the review delineates future research trajectories to bridge these gaps and advance personalized care, ultimately aiming to improve clinical outcomes and patient-centered management.
Keywords: polycystic ovary syndrome, insulin resistance, hyperandrogenism, lifestyle interventions, pharmacological treatment
1Department of Reproduction, Qingdao Municipal Hospital, Qingdao, 266071, People’s Republic of China; 2Department of Gynecology, Qingdao Municipal Hospital, Qingdao, 266071, People’s Republic of China
Correspondence: Tao Lu, Email taoluanthony@126.com Jingyuan Wang, Email jingyuan_wangqd09@163.com
Abstract: Polycystic ovary syndrome (PCOS) constitutes a prevalent endocrine and metabolic disorder that substantially compromises reproductive and metabolic health in women of reproductive age. The escalating global prevalence of this multisystem condition underscores the need for innovative, interdisciplinary management strategies. Unlike existing reviews, this paper offers a distinctive synthesis of recent advances in PCOS clinical management, with a novel focus on integrating lifestyle modifications, pharmacological interventions, assisted reproductive techniques, and emerging therapeutic approaches such as digital health tools and personalized medicine. It critically evaluates the mechanisms, efficacy, and limitations of these strategies, while identifying underexplored gaps in current knowledge and practice. Furthermore, the review delineates future research trajectories to bridge these gaps and advance personalized care, ultimately aiming to improve clinical outcomes and patient-centered management.
Keywords: polycystic ovary syndrome, insulin resistance, hyperandrogenism, lifestyle interventions, pharmacological treatment