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已发表论文
早期卵巢畸胎瘤切除改善抗 N-甲基-D-天冬氨酸受体脑炎结局：两例病例系列
Authors Lan X , Chen J, Yang Y, Zhong H, Chen C, Liang Y
Received 20 October 2025
Accepted for publication 14 January 2026
Published 4 February 2026 Volume 2026:18 573051
DOI https://doi.org/10.2147/IJWH.S573051
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Xi Lan,1,2,* JiaYu Chen,1,* Yang Yang,1 Hua Zhong,1 ChangYi Chen,1 YanChun Liang1,2
1Department of Obstetrics and Gynecology, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, 530022, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China
*These authors contributed equally to this work
Correspondence: YanChun Liang, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86 13751722697, Email lyanchun@mail.sysu.edu.cn
Objective: Anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroimmune disorder closely associated with ovarian teratomas, yet the prognostic impact of early surgical intervention requires further exploration. This dual-case analysis highlights the critical role of timely teratoma resection in improving clinical outcomes.
Case Presentation: Case 1 involved a 34-year-old female presenting with psychiatric-dominant symptoms. A right salpingo-oophorectomy (pathology: immature teratoma) was performed 18 days post-onset, followed by rituximab therapy, resulting in full recovery with a modified Rankin Scale (mRS) score of 0. Case 2, a 16-year-old adolescent, underwent an initial laparoscopic ovarian teratoma resection (pathology: mature teratoma) 28 days post-onset. Residual tumor necessitated a second surgery (on day 95), leaving mild quadriparesis and ataxia with a mRS score of 2. Both cases remained recurrence-free during follow-up (17 and 14 months, respectively).
Conclusion: Early surgical resection of ovarian teratomas is critical for favorable prognosis in anti-NMDAR encephalitis, halting antibody production and preventing irreversible neurological damage.
Keywords: anti-NMDAR encephalitis, ovarian teratoma, early surgery, prognosis, case Series
1Department of Obstetrics and Gynecology, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, 530022, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China
*These authors contributed equally to this work
Correspondence: YanChun Liang, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86 13751722697, Email lyanchun@mail.sysu.edu.cn
Objective: Anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroimmune disorder closely associated with ovarian teratomas, yet the prognostic impact of early surgical intervention requires further exploration. This dual-case analysis highlights the critical role of timely teratoma resection in improving clinical outcomes.
Case Presentation: Case 1 involved a 34-year-old female presenting with psychiatric-dominant symptoms. A right salpingo-oophorectomy (pathology: immature teratoma) was performed 18 days post-onset, followed by rituximab therapy, resulting in full recovery with a modified Rankin Scale (mRS) score of 0. Case 2, a 16-year-old adolescent, underwent an initial laparoscopic ovarian teratoma resection (pathology: mature teratoma) 28 days post-onset. Residual tumor necessitated a second surgery (on day 95), leaving mild quadriparesis and ataxia with a mRS score of 2. Both cases remained recurrence-free during follow-up (17 and 14 months, respectively).
Conclusion: Early surgical resection of ovarian teratomas is critical for favorable prognosis in anti-NMDAR encephalitis, halting antibody production and preventing irreversible neurological damage.
Keywords: anti-NMDAR encephalitis, ovarian teratoma, early surgery, prognosis, case Series