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已发表论文
藜麦基于 β 细胞功能改善早期 2 型糖尿病患者的葡萄糖代谢和血糖波动：一项随机研究
Authors Zhang J, Cong R, Xu L, Liu H, Wang W, Diao Y, Hu X, Tang K
Received 27 November 2025
Accepted for publication 30 January 2026
Published 4 February 2026 Volume 2026:19 584727
DOI https://doi.org/10.2147/IJGM.S584727
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jacopo Manso
Jianbo Zhang,1– 5 Riping Cong,1 Lujia Xu,1 Haijiao Liu,1 Wei Wang,1 Yingli Diao,1 Xiaoshuang Hu,6 Kuanxiao Tang1,2
1Department of General Practice, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Geriatrics Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 3Chest Pain Center, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 4Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Jinan, Shandong, People’s Republic of China; 5Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 6Department of Surgical Clinic, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
Correspondence: Kuanxiao Tang, Department of General Practice, Qilu Hospital of Shandong University, No. 107, Wen Hua Xi Road, Jinan, Shandong, 250012, People’s Republic of China, Tel +86 0531-82166120, Fax +86-531-82166844, Email tangkx_ql@hotmail.com
Introduction: Clinical studies are yet to determine whether quinoa improves metabolism in patients with type 2 diabetes mellitus (T2DM).
Methods: Sixty patients with early-stage T2DM were randomly assigned to the quinoa diet (QD) or regular diet (RD) groups. Oral glucose tolerance tests (OGTTs) and dynamic blood glucose monitoring were performed before and after the intervention.
Results: Ninety-seven percent of patients adhered to the dietary intervention plan involving quinoa. In addition to postprandial blood glucose and cholesterol, fasting blood glucose, glycosylated haemoglobin, triglycerides, and insulin resistance decreased in the QD group. The reductions in postprandial blood glucose (4.57 ± 2.7 mmol/L vs 2.2 ± 2.8 mmol/L, P < 0.001) and glycosylated haemoglobin (0.86 ± 0.24 vs 0.28 ± 0.23, P =0.042) as well as the increase in the time in range (94.52 ± 4.88% vs 87.83 ± 9.9%, P < 0.05) were more pronounced in the QD group. The QD group achieved a higher rate of medication reduction or withdrawal (28.6% vs 7.1%, P =0.036). Multivariate analysis indicated that HOMA-β and quinoa consumption were the primary risk factors.
Conclusion: β-cell function is the key factor influencing quinoa’s ability to improve metabolism and achieve diabetes remission in patients with early-stage T2DM.
Keywords: type 2 diabetes mellitus, quinoa dietary intervention, glycolipid metabolism, glycaemic fluctuations
1Department of General Practice, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Geriatrics Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 3Chest Pain Center, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 4Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Jinan, Shandong, People’s Republic of China; 5Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 6Department of Surgical Clinic, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
Correspondence: Kuanxiao Tang, Department of General Practice, Qilu Hospital of Shandong University, No. 107, Wen Hua Xi Road, Jinan, Shandong, 250012, People’s Republic of China, Tel +86 0531-82166120, Fax +86-531-82166844, Email tangkx_ql@hotmail.com
Introduction: Clinical studies are yet to determine whether quinoa improves metabolism in patients with type 2 diabetes mellitus (T2DM).
Methods: Sixty patients with early-stage T2DM were randomly assigned to the quinoa diet (QD) or regular diet (RD) groups. Oral glucose tolerance tests (OGTTs) and dynamic blood glucose monitoring were performed before and after the intervention.
Results: Ninety-seven percent of patients adhered to the dietary intervention plan involving quinoa. In addition to postprandial blood glucose and cholesterol, fasting blood glucose, glycosylated haemoglobin, triglycerides, and insulin resistance decreased in the QD group. The reductions in postprandial blood glucose (4.57 ± 2.7 mmol/L vs 2.2 ± 2.8 mmol/L, P < 0.001) and glycosylated haemoglobin (0.86 ± 0.24 vs 0.28 ± 0.23, P =0.042) as well as the increase in the time in range (94.52 ± 4.88% vs 87.83 ± 9.9%, P < 0.05) were more pronounced in the QD group. The QD group achieved a higher rate of medication reduction or withdrawal (28.6% vs 7.1%, P =0.036). Multivariate analysis indicated that HOMA-β and quinoa consumption were the primary risk factors.
Conclusion: β-cell function is the key factor influencing quinoa’s ability to improve metabolism and achieve diabetes remission in patients with early-stage T2DM.
Keywords: type 2 diabetes mellitus, quinoa dietary intervention, glycolipid metabolism, glycaemic fluctuations