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已发表论文
CT 和 MRI 检测结节性硬化症颅内及颅外表现的比较评估
Authors He J, Deng LH , Wang K, Deng C , Lai YM, Zeng Y
Received 3 August 2025
Accepted for publication 10 January 2026
Published 4 February 2026 Volume 2026:22 558051
DOI https://doi.org/10.2147/NDT.S558051
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Taro Kishi
Jun He,1,* Li-Hua Deng,1,2,* Kang Wang,1 Chao Deng,1 Yuan-Mei Lai,1 Yan Zeng3
1Department of Radiology, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 2 7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China; 3Department of Ultrasound, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Zeng, Department of Ultrasound, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China, Email zengyan9582@163.com
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by the formation of benign tumors in multiple organs. Neuroimaging plays a pivotal role in diagnosis and surveillance of intracranial and extracranial manifestations.
Objective: To evaluate and compare the diagnostic performance of CT and MRI in detecting intracranial and extracranial lesions associated with TSC.
Methods: A retrospective analysis was conducted on imaging data from 57 patients diagnosed with TSC. Cranial CT and routine MRI findings were reviewed and compared. In addition, abdominal and thoracic CT findings were evaluated for renal, hepatic, pulmonary, and skeletal involvement.
Results: Subependymal calcified nodules were observed in 51/57 (89.5%) patients, with a CT detection rate of 100% (46/46), significantly higher than routine MRI (68.4%, 13/19; P < 0.001). Cortical dysplasia lesions were found in 19/57 (33.3%) patients, with significant difference between CT (10/46, 21.7%) and routine MRI (16/19, 84.2%; P < 0.001). Subependymal giant cell astrocytoma (SEGA) lesions were detected in 11/19 (19.3%) cases with no statistical difference between CT (7/46, 15.2%) and routine MRI (6/19, 31.6%; P = 0.250). Cerebral fissure malformation and cranial bone dysplasia were detected in 3/57 (5.3%) and 2/57 (3.5%) patients, respectively. Extracranially, renal angiomyolipoma (AML) lesions were detected in 12/21 (57.1%) patients, hepatic AMLs in 5/21 (23.8%), multifocal micronodular pneumocyte hyperplasia (MMPH) lesions in 5/15 (33.3%), pulmonary lymphangioleiomyomatosis (LAM) lesions in 3/15 (20.0%), and multifocal bone sclerosis in 13/36 (36.1%) by CT.
Conclusion: CT and routine MRI demonstrated lesion-specific, complementary roles in TSC. CT preferentially identified calcified lesions and delineated extracranial multisystem involvement, whereas MRI offered an advantage in the detection of cortical dysplasia and other soft-tissue abnormalities. Integrating intracranial and extracranial imaging within a single cohort, this study supported a practical, modality-tailored CT–MRI approach for comprehensive assessment and risk-adapted surveillance in TSC.
Keywords: tuberous sclerosis complex, CT, MRI, comparative evaluation
1Department of Radiology, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 2 7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China; 3Department of Ultrasound, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Zeng, Department of Ultrasound, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China, Email zengyan9582@163.com
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by the formation of benign tumors in multiple organs. Neuroimaging plays a pivotal role in diagnosis and surveillance of intracranial and extracranial manifestations.
Objective: To evaluate and compare the diagnostic performance of CT and MRI in detecting intracranial and extracranial lesions associated with TSC.
Methods: A retrospective analysis was conducted on imaging data from 57 patients diagnosed with TSC. Cranial CT and routine MRI findings were reviewed and compared. In addition, abdominal and thoracic CT findings were evaluated for renal, hepatic, pulmonary, and skeletal involvement.
Results: Subependymal calcified nodules were observed in 51/57 (89.5%) patients, with a CT detection rate of 100% (46/46), significantly higher than routine MRI (68.4%, 13/19; P < 0.001). Cortical dysplasia lesions were found in 19/57 (33.3%) patients, with significant difference between CT (10/46, 21.7%) and routine MRI (16/19, 84.2%; P < 0.001). Subependymal giant cell astrocytoma (SEGA) lesions were detected in 11/19 (19.3%) cases with no statistical difference between CT (7/46, 15.2%) and routine MRI (6/19, 31.6%; P = 0.250). Cerebral fissure malformation and cranial bone dysplasia were detected in 3/57 (5.3%) and 2/57 (3.5%) patients, respectively. Extracranially, renal angiomyolipoma (AML) lesions were detected in 12/21 (57.1%) patients, hepatic AMLs in 5/21 (23.8%), multifocal micronodular pneumocyte hyperplasia (MMPH) lesions in 5/15 (33.3%), pulmonary lymphangioleiomyomatosis (LAM) lesions in 3/15 (20.0%), and multifocal bone sclerosis in 13/36 (36.1%) by CT.
Conclusion: CT and routine MRI demonstrated lesion-specific, complementary roles in TSC. CT preferentially identified calcified lesions and delineated extracranial multisystem involvement, whereas MRI offered an advantage in the detection of cortical dysplasia and other soft-tissue abnormalities. Integrating intracranial and extracranial imaging within a single cohort, this study supported a practical, modality-tailored CT–MRI approach for comprehensive assessment and risk-adapted surveillance in TSC.
Keywords: tuberous sclerosis complex, CT, MRI, comparative evaluation