120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
MPNFS 框架用于管理接受免疫治疗肺癌患者的带状疱疹和难治性疼痛：一例病例报告
Authors Qiao S, Zhang X , Tian S, Wu Y , Li Y, Tong Y
Received 10 November 2025
Accepted for publication 29 January 2026
Published 5 February 2026 Volume 2026:18 579681
DOI https://doi.org/10.2147/CMAR.S579681
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Bilikere Dwarakanath
Shina Qiao,1 Xiaoming Zhang,1 Suming Tian,2 Yue Wu,2 Ying Li,1 Yingge Tong3
1Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Pain Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 3Public Health and Nursing College, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Shina Qiao, Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People’s Republic of China, Email qiaoshina08@zju.edu.cn
Abstract: Patients undergoing treatment with immune checkpoint inhibitors (ICIs) for advanced lung cancer are at increased risk of viral reactivation and severe neuropathic pain. These complications exacerbate the overall symptom burden and psychological distress, underscoring the necessity for integrated nursing interventions aimed at enhancing both physical and psychological well-being. This constitutes a critical priority in contemporary clinical nursing research. We report a 63-year-old woman with stage IV lung adenocarcinoma (cT2aN2M1c, bone metastases) on sindilizumab and anlotinib, who developed severe cervical herpes zoster while carrying an implanted intrathecal drug delivery system (IDDS). She presented with explosive neuropathic pain (NRS 6– 7), cancer pain (NRS 5– 6), and severe anxiety (GAD-7 = 16). Guided by the Medication–Psychological–Nursing–Family–Support (MPNFS) framework, which underscores that nursing care should extend beyond routine medical management to incorporate integrated interventions, and in alignment with the integrative oncology guidelines from the Society for Integrative Oncology (SIO) and the American Society of Clinical Oncology (ASCO), we implemented a coordinated intervention. It encompassed antiviral therapy, multimodal analgesia, psychological support, family engagement, and structured WeChat follow-up. This led to lesion resolution, significant pain and anxiety reduction (NRS 2– 3; GAD-7 = 8), and safe IDDS retention, enabling transition to community for sustained symptom control. This case achieved key outcomes: safe IDDS preservation, effective symptom management, and seamless care continuity. It demonstrates that the MPNFS-guided integrative nursing is a clinical framework for managing complex immunotherapy-related complications, highlighting its vital role in facilitating multidisciplinary coordination and supporting patients through high-risk care transitions.
Keywords: immunotherapy, integrative oncology, lung cancer, MPNFS framework, neuropathic pain
1Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Pain Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 3Public Health and Nursing College, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Shina Qiao, Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, People’s Republic of China, Email qiaoshina08@zju.edu.cn
Abstract: Patients undergoing treatment with immune checkpoint inhibitors (ICIs) for advanced lung cancer are at increased risk of viral reactivation and severe neuropathic pain. These complications exacerbate the overall symptom burden and psychological distress, underscoring the necessity for integrated nursing interventions aimed at enhancing both physical and psychological well-being. This constitutes a critical priority in contemporary clinical nursing research. We report a 63-year-old woman with stage IV lung adenocarcinoma (cT2aN2M1c, bone metastases) on sindilizumab and anlotinib, who developed severe cervical herpes zoster while carrying an implanted intrathecal drug delivery system (IDDS). She presented with explosive neuropathic pain (NRS 6– 7), cancer pain (NRS 5– 6), and severe anxiety (GAD-7 = 16). Guided by the Medication–Psychological–Nursing–Family–Support (MPNFS) framework, which underscores that nursing care should extend beyond routine medical management to incorporate integrated interventions, and in alignment with the integrative oncology guidelines from the Society for Integrative Oncology (SIO) and the American Society of Clinical Oncology (ASCO), we implemented a coordinated intervention. It encompassed antiviral therapy, multimodal analgesia, psychological support, family engagement, and structured WeChat follow-up. This led to lesion resolution, significant pain and anxiety reduction (NRS 2– 3; GAD-7 = 8), and safe IDDS retention, enabling transition to community for sustained symptom control. This case achieved key outcomes: safe IDDS preservation, effective symptom management, and seamless care continuity. It demonstrates that the MPNFS-guided integrative nursing is a clinical framework for managing complex immunotherapy-related complications, highlighting its vital role in facilitating multidisciplinary coordination and supporting patients through high-risk care transitions.
Keywords: immunotherapy, integrative oncology, lung cancer, MPNFS framework, neuropathic pain