120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
睡眠障碍通过犬尿氨酸酶加重术后疼痛的证据
Authors Huang N, Chen Y, Yang X, Tao C, Zhang Y, Yang Y, Shu B, Duan G , Chen Y
Received 11 October 2025
Accepted for publication 19 January 2026
Published 5 February 2026 Volume 2026:20 565401
DOI https://doi.org/10.2147/DDDT.S565401
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Leonidas D. Panos
Niannian Huang,* Yongqin Chen,* Xinqing Yang, Chengkun Tao, Yifan Zhang, Yi Yang, Bin Shu, Guangyou Duan, Yuanjing Chen
Department of Anaesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guangyou Duan, Email duangy@hospital.cqmu.edu.cn Yuanjing Chen, Email 304384@hospital.cqmu.edu.cn
Background: Surgery is a frequently employed intervention for patients; however, 30– 80% of patients report moderate to severe pain after surgery. Postoperative pain is affected by a variety of factors, with sleep disturbance being a critical modulating factor that exacerbates postoperative pain intensity. Kynureninase (KYNU), a key hydrolase in the kynurenine pathway that produces quinolinic acid, may link sleep disturbances to pain sensitization; however, the underlying mechanisms remain unclear.
Methods: We obtained skin and blood samples from 40 abdominal surgery patients and performed whole-transcriptome sequencing. Through analysis of the intersecting gene sets between patients with adequate and inadequate analgesia, as well as between those with sleep disorder and normal sleep, we identified genes significantly linked to both sleep disorders and postoperative pain. We established an animal model by making a hind paw plantar incision in mice subjected to chronic sleep deprivation. We then performed behavioral tests, including the tail flick test and von Frey filaments, measured the expression of differentially expressed genes via real-time quantitative polymerase chain reaction and immunofluorescence, and validated the results using pharmacological and calcium imaging methods.
Results: We found that sleep deprivation greatly exacerbated postoperative pain, and KYNU was notably higher in the skin, blood, and dorsal root ganglion (DRG). Repeated intraperitoneal injections of carbidopa, a KYNU modulator, reduced the severity of pain induced by sleep deprivation and abnormal excitability of DRG neurons. Furthermore, in preclinical models, carbidopa treatment effectively reduced both inflammatory and neuropathic pain.
Conclusion: We conclude that the upregulated expression of KYNU is associated with the exacerbation of postoperative pain due to sleep deprivation and identified the compound carbidopa as possessing significant analgesic potential.
Keywords: postoperative pain, sleep disorders, kynureninase, neural excitability, carbidopa
Department of Anaesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guangyou Duan, Email duangy@hospital.cqmu.edu.cn Yuanjing Chen, Email 304384@hospital.cqmu.edu.cn
Background: Surgery is a frequently employed intervention for patients; however, 30– 80% of patients report moderate to severe pain after surgery. Postoperative pain is affected by a variety of factors, with sleep disturbance being a critical modulating factor that exacerbates postoperative pain intensity. Kynureninase (KYNU), a key hydrolase in the kynurenine pathway that produces quinolinic acid, may link sleep disturbances to pain sensitization; however, the underlying mechanisms remain unclear.
Methods: We obtained skin and blood samples from 40 abdominal surgery patients and performed whole-transcriptome sequencing. Through analysis of the intersecting gene sets between patients with adequate and inadequate analgesia, as well as between those with sleep disorder and normal sleep, we identified genes significantly linked to both sleep disorders and postoperative pain. We established an animal model by making a hind paw plantar incision in mice subjected to chronic sleep deprivation. We then performed behavioral tests, including the tail flick test and von Frey filaments, measured the expression of differentially expressed genes via real-time quantitative polymerase chain reaction and immunofluorescence, and validated the results using pharmacological and calcium imaging methods.
Results: We found that sleep deprivation greatly exacerbated postoperative pain, and KYNU was notably higher in the skin, blood, and dorsal root ganglion (DRG). Repeated intraperitoneal injections of carbidopa, a KYNU modulator, reduced the severity of pain induced by sleep deprivation and abnormal excitability of DRG neurons. Furthermore, in preclinical models, carbidopa treatment effectively reduced both inflammatory and neuropathic pain.
Conclusion: We conclude that the upregulated expression of KYNU is associated with the exacerbation of postoperative pain due to sleep deprivation and identified the compound carbidopa as possessing significant analgesic potential.
Keywords: postoperative pain, sleep disorders, kynureninase, neural excitability, carbidopa