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已发表论文
皮下脂膜炎样 T 细胞淋巴瘤的临床病理特征和生存预后：基于 SEER 数据库的人群研究及单中心病例补充验证
Received 11 October 2025
Accepted for publication 30 January 2026
Published 5 February 2026 Volume 2026:19 567402
DOI https://doi.org/10.2147/IJGM.S567402
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Dana Kristjansson
Li Zhou,1– 4 Jiwei Li5
1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, People’s Republic of China; 3Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, People’s Republic of China; 4Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, People’s Republic of China; 5Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Correspondence: Jiwei Li, Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410000, People’s Republic of China, Email lijiwei2021@csu.edu.cn
Background: Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare entity which primarily involved skin and subcutaneous tissue, with clinicopathological features similar to subcutaneous panniculitis. The etiology, clinical features, clinical outcomes and prognostic factors remain largely unknown.
Methods: To gain insight into this distinct entity, we summarized the clinicopathologic features of 8 unpublished SPTCL cases and performed a comprehensive analysis based on SEER (Surveillance, Epidemiology, and End Results) database.
Results: Clinically, subcutaneous nodules with no tenderness appeared firstly in seven patients, and cough in one patient. Hemophagocytic syndrome developed in 3 patients. The median progression-free survival (PFS) for the whole cohort was 43 months, while the median overall survival (OS) has not reached. We identified a cohort of 210 SPTCL patients between 2000 and 2020 based on SEER database. Over half of patients had B symptoms (56.2%) and present at advanced stage (55.6%). The 5-year overall survival (OS) rate was 77.6% for the whole cohort. Multivariate analysis showed that age > 60 years and diagnosis before the year 2008 were important prognostic factors of OS for SPTCL.
Conclusion: Our results identified the clinical characteristics, OS and prognostic factors of a large cohort of SPTCL.
Keywords: subcutaneous panniculitis-like T cell lymphoma, T cell lymphoma, SEER database, outcome, prognostic factors
1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, People’s Republic of China; 3Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, People’s Republic of China; 4Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, People’s Republic of China; 5Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Correspondence: Jiwei Li, Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410000, People’s Republic of China, Email lijiwei2021@csu.edu.cn
Background: Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare entity which primarily involved skin and subcutaneous tissue, with clinicopathological features similar to subcutaneous panniculitis. The etiology, clinical features, clinical outcomes and prognostic factors remain largely unknown.
Methods: To gain insight into this distinct entity, we summarized the clinicopathologic features of 8 unpublished SPTCL cases and performed a comprehensive analysis based on SEER (Surveillance, Epidemiology, and End Results) database.
Results: Clinically, subcutaneous nodules with no tenderness appeared firstly in seven patients, and cough in one patient. Hemophagocytic syndrome developed in 3 patients. The median progression-free survival (PFS) for the whole cohort was 43 months, while the median overall survival (OS) has not reached. We identified a cohort of 210 SPTCL patients between 2000 and 2020 based on SEER database. Over half of patients had B symptoms (56.2%) and present at advanced stage (55.6%). The 5-year overall survival (OS) rate was 77.6% for the whole cohort. Multivariate analysis showed that age > 60 years and diagnosis before the year 2008 were important prognostic factors of OS for SPTCL.
Conclusion: Our results identified the clinical characteristics, OS and prognostic factors of a large cohort of SPTCL.
Keywords: subcutaneous panniculitis-like T cell lymphoma, T cell lymphoma, SEER database, outcome, prognostic factors