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已发表论文
进展在诊断和治疗的类风湿关节炎：来自病理机制至中西医结合治疗策略
Authors Wang M, Pan L , Guan R
Received 20 October 2025
Accepted for publication 19 January 2026
Published 5 February 2026 Volume 2026:19 575521
DOI https://doi.org/10.2147/IJGM.S575521
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Mingxian Wang,1 Limin Pan,2 Ruiqian Guan3
1Heilongjiang University of Chinese Medicine, Harbin, 150006, People’s Republic of China; 2First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, People’s Republic of China; 3Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, People’s Republic of China
Correspondence: Ruiqian Guan, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, People’s Republic of China, Email 196224917@qq.com Limin Pan, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, 26 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, 150040, People’s Republic of China, Email 2621902358@qq.com
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease whose exact cause remains unclear and is likely the result of multiple factors such as genetics and environmental influences. This disease primarily affects the joints and subsequently presents with extra-articular manifestations.The pathogenesis of RA is complex, and current research is yet to fully elucidate the underlying mechanisms. Consequently, investigations into the pathophysiological processes of RA remain in its early stages. Recent advancements in diagnostic methodologies and pharmacological interventions have significantly improved RA management. A growing number of novel therapeutic agents have been introduced, with methotrexate (MTX) remaining the cornerstone of first-line treatment. Furthermore, contemporary drug development efforts have increasingly focused on molecular medicine to enhance the therapeutic efficacy and safety profiles. Traditional Chinese medicine (TCM), with its unique theoretical system and therapeutic approaches, demonstrates promising potential in the treatment of RA and is increasingly attracting global attention. Clinical studies on Tripterygium wilfordii (thunder god vine) and preparations of Paeonia lactiflora (white peony) in rheumatoid arthritis and related conditions have also demonstrated certain efficacy and safety of Chinese herbal medicine. Currently, the integration of traditional Chinese and Western medical approaches for RA treatment is gaining wider acceptance. Therefore, this review will focus on exploring the potential of traditional Chinese medicine in improving RA outcomes, based on the diagnosis, epidemiology, and pathophysiological mechanisms of rheumatoid arthritis.
Keywords: rheumatoid arthritis, autoimmunity, traditional Chinese medicine, combination of Chinese and Western medicine
1Heilongjiang University of Chinese Medicine, Harbin, 150006, People’s Republic of China; 2First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, People’s Republic of China; 3Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, People’s Republic of China
Correspondence: Ruiqian Guan, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, People’s Republic of China, Email 196224917@qq.com Limin Pan, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, 26 Heping Road, Xiangfang District, Harbin, Heilongjiang Province, 150040, People’s Republic of China, Email 2621902358@qq.com
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease whose exact cause remains unclear and is likely the result of multiple factors such as genetics and environmental influences. This disease primarily affects the joints and subsequently presents with extra-articular manifestations.The pathogenesis of RA is complex, and current research is yet to fully elucidate the underlying mechanisms. Consequently, investigations into the pathophysiological processes of RA remain in its early stages. Recent advancements in diagnostic methodologies and pharmacological interventions have significantly improved RA management. A growing number of novel therapeutic agents have been introduced, with methotrexate (MTX) remaining the cornerstone of first-line treatment. Furthermore, contemporary drug development efforts have increasingly focused on molecular medicine to enhance the therapeutic efficacy and safety profiles. Traditional Chinese medicine (TCM), with its unique theoretical system and therapeutic approaches, demonstrates promising potential in the treatment of RA and is increasingly attracting global attention. Clinical studies on Tripterygium wilfordii (thunder god vine) and preparations of Paeonia lactiflora (white peony) in rheumatoid arthritis and related conditions have also demonstrated certain efficacy and safety of Chinese herbal medicine. Currently, the integration of traditional Chinese and Western medical approaches for RA treatment is gaining wider acceptance. Therefore, this review will focus on exploring the potential of traditional Chinese medicine in improving RA outcomes, based on the diagnosis, epidemiology, and pathophysiological mechanisms of rheumatoid arthritis.
Keywords: rheumatoid arthritis, autoimmunity, traditional Chinese medicine, combination of Chinese and Western medicine