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已发表论文
关联之间亚临床白蛋白尿和早期动脉僵硬在中国成人伴 2型糖尿病
Authors Xuan Y , Zhu F, Tang D, Wang X, Wang S, Shen Y, Lu L
Received 22 October 2025
Accepted for publication 14 January 2026
Published 5 February 2026 Volume 2026:19 575958
DOI https://doi.org/10.2147/DMSO.S575958
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Yan Xuan, Fanfan Zhu, Dou Tang, Xun Wang, Sujie Wang, Ying Shen, Leiqun Lu
Department of Endocrinology, Shanghai Ruijin Hospital, Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Correspondence: Ying Shen, Email shenying902@163.com Leiqun Lu, Email llqlzy@163.com
Background: While elevated microalbuminuria is closely associated with arterial stiffness, the relationship between high-normal albuminuria and arterial stiffness remains unclear among Chinese adults with type 2 diabetes.
Objective: This study aimed to investigate the association between subclinical albuminuria and early arterial stiffness in a cohort of Chinese adults with T2DM, focusing on sex-specific differences and threshold effects.
Methods: In this cross-sectional study, 1119 Chinese adults with type 2 diabetes and without overt kidney or cardiovascular disease were enrolled. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by tertiles of the logarithmically transformed urinary albumin-to-creatinine ratio (lg-UACR). We employed correlation analysis to examine continuous relationships and multivariable logistic regression to assess the odds of high baPWV across lg-UACR tertiles. Sex-stratified and restricted cubic spline analyses were conducted to explore effect modification and nonlinearity.
Results: Higher lg-UACR tertiles demonstrated a dose-dependent association with arterial stiffness risk in the overall cohort. Sex-stratified analysis revealed this association was statistically significant only in women. Among postmenopausal women, a threshold effect was observed at lg-UACR =1.1 (UACR =12.6 mg/g), beyond which the significant correlation between microalbuminuria and arterial stiffness was attenuated.
Conclusion: Elevated UACR in normal range is associated with arterial stiffness risk in Chinese women with type 2 diabetes, but not in men. Among postmenopausal women, this link is significant only below a lg-UACR threshold of 1.1 and is abolished at or above this level. This critical threshold effect, modulated by menopause, suggests sex-specific UACR criteria for vascular risk assessment.
Keywords: urinary albumin-creatinine ratio, brachial-ankle pulse wave velocity, arterial stiffness, type 2 diabetes
Department of Endocrinology, Shanghai Ruijin Hospital, Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Correspondence: Ying Shen, Email shenying902@163.com Leiqun Lu, Email llqlzy@163.com
Background: While elevated microalbuminuria is closely associated with arterial stiffness, the relationship between high-normal albuminuria and arterial stiffness remains unclear among Chinese adults with type 2 diabetes.
Objective: This study aimed to investigate the association between subclinical albuminuria and early arterial stiffness in a cohort of Chinese adults with T2DM, focusing on sex-specific differences and threshold effects.
Methods: In this cross-sectional study, 1119 Chinese adults with type 2 diabetes and without overt kidney or cardiovascular disease were enrolled. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by tertiles of the logarithmically transformed urinary albumin-to-creatinine ratio (lg-UACR). We employed correlation analysis to examine continuous relationships and multivariable logistic regression to assess the odds of high baPWV across lg-UACR tertiles. Sex-stratified and restricted cubic spline analyses were conducted to explore effect modification and nonlinearity.
Results: Higher lg-UACR tertiles demonstrated a dose-dependent association with arterial stiffness risk in the overall cohort. Sex-stratified analysis revealed this association was statistically significant only in women. Among postmenopausal women, a threshold effect was observed at lg-UACR =1.1 (UACR =12.6 mg/g), beyond which the significant correlation between microalbuminuria and arterial stiffness was attenuated.
Conclusion: Elevated UACR in normal range is associated with arterial stiffness risk in Chinese women with type 2 diabetes, but not in men. Among postmenopausal women, this link is significant only below a lg-UACR threshold of 1.1 and is abolished at or above this level. This critical threshold effect, modulated by menopause, suggests sex-specific UACR criteria for vascular risk assessment.
Keywords: urinary albumin-creatinine ratio, brachial-ankle pulse wave velocity, arterial stiffness, type 2 diabetes