120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
铁蛋白纳米笼用于神经退行性疾病治疗的研究图景
Authors Wen S, Gao J, Sun J, Li X, Xu XL , Chen J
Received 3 October 2025
Accepted for publication 20 January 2026
Published 6 February 2026 Volume 2026:21 571993
DOI https://doi.org/10.2147/IJN.S571993
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr RDK Misra
Shilin Wen,1– 3,* Jingjing Gao,1– 3,* Jingqi Sun,2 Xiaoyan Li,2 Xiao-Ling Xu,2 Jianer Chen1,3,4
1Department of Rehabilitation, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Shulan International Medical College, Zhejiang Shuren University, Hangzhou, People’s Republic of China; 3The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 4Department of Neurorehabilitation, Zhejiang Rehabilitation Medical Center, Hangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiao-Ling Xu, Email ziyao1988@zju.edu.cn Jianer Chen, Email chenje@zcmu.edu.cn
Abstract: The blood-brain barrier (BBB) is a sophisticated structure composed of brain capillary endothelial cells, basement membrane, and neuroglial membrane, which strictly regulates substance exchange between the blood and brain tissue. While maintaining the homeostasis of the central nervous system, it blocks the entry of over 98% of small-molecule drugs and nearly all macromolecular drugs into the brain parenchyma, posing a significant challenge for the treatment of neurodegenerative diseases (NDs). Owing to their unique hollow architecture, favorable biocompatibility, reversible self-assembly properties, intrinsic targeting capability, and surface modifiability, natural ferritin nanocages have garnered substantial attention in the fields of biomedicine and nanotechnology. This review outlines the pathological mechanisms of NDs, the structure and function of the BBB, as well as its transport mechanisms. It highlights the advantages of ferritin nanocages in crossing the BBB—attributed to their natural nanostructure, brain-targeting potential, and capacity for functionalized surface modification—along with their drug loading capacity, antioxidant activity, and favorable biosafety profile. Recent advances in the application of natural ferritin nanocages for the diagnosis and therapy of NDs are also summarized. However, it is important to note that the evidence supporting their application in NDs remains more limited compared to their extensive research in cancer therapeutics. Finally, current challenges and future prospects of ferritin-based nanoplatforms are discussed, providing valuable insights for developing ferritin nanocage-based strategies in the diagnosis and treatment of NDs.
Keywords: ferritin nanocage, blood-brain barrier, neurodegenerative diseases, receptor-mediated transcytosis
1Department of Rehabilitation, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Shulan International Medical College, Zhejiang Shuren University, Hangzhou, People’s Republic of China; 3The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 4Department of Neurorehabilitation, Zhejiang Rehabilitation Medical Center, Hangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiao-Ling Xu, Email ziyao1988@zju.edu.cn Jianer Chen, Email chenje@zcmu.edu.cn
Abstract: The blood-brain barrier (BBB) is a sophisticated structure composed of brain capillary endothelial cells, basement membrane, and neuroglial membrane, which strictly regulates substance exchange between the blood and brain tissue. While maintaining the homeostasis of the central nervous system, it blocks the entry of over 98% of small-molecule drugs and nearly all macromolecular drugs into the brain parenchyma, posing a significant challenge for the treatment of neurodegenerative diseases (NDs). Owing to their unique hollow architecture, favorable biocompatibility, reversible self-assembly properties, intrinsic targeting capability, and surface modifiability, natural ferritin nanocages have garnered substantial attention in the fields of biomedicine and nanotechnology. This review outlines the pathological mechanisms of NDs, the structure and function of the BBB, as well as its transport mechanisms. It highlights the advantages of ferritin nanocages in crossing the BBB—attributed to their natural nanostructure, brain-targeting potential, and capacity for functionalized surface modification—along with their drug loading capacity, antioxidant activity, and favorable biosafety profile. Recent advances in the application of natural ferritin nanocages for the diagnosis and therapy of NDs are also summarized. However, it is important to note that the evidence supporting their application in NDs remains more limited compared to their extensive research in cancer therapeutics. Finally, current challenges and future prospects of ferritin-based nanoplatforms are discussed, providing valuable insights for developing ferritin nanocage-based strategies in the diagnosis and treatment of NDs.
Keywords: ferritin nanocage, blood-brain barrier, neurodegenerative diseases, receptor-mediated transcytosis