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已发表论文
心肌肌钙蛋白联合 p-SOFA 评分对 PCIS ≥70 脓毒症患儿的预测价值
Received 16 September 2025
Accepted for publication 22 January 2026
Published 6 February 2026 Volume 2026:19 562566
DOI https://doi.org/10.2147/IJGM.S562566
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Rui Zhu, Kai Ge
Department of Pediatrics, Shu Yang Hospital of TCM, Suqian, Jiangsu, 223600, People’s Republic of China
Correspondence: Kai Ge, Department of Pediatrics, Shu Yang Hospital of TCM, No. 28, Shanghai Middle Road, Shuyang County, Suqian, Jiangsu, 223600, People’s Republic of China, Tel +86– 0527-83551087, Email gekai915@yeah.net
Objective: To analyze the prediction value of cardiac troponin I (cTnI), cardiac troponin T (cTnT), and the pediatric Sequential Organ Failure Assessment (p-SOFA) score in children with severe sepsis.
Methods: 80 children with sepsis [Pediatric Critical Illness Score (PCIS) ≥ 70] were selected and categorized into severe sepsis group (PCIS score of 71– 80, n=52) and non-severe sepsis group (PCIS score > 80, n=28) according to the PCIS score, and 50 non-septic children admitted to our hospital during the same period were selected as non-sepsis group. The value of cTnT, cTnI, p-SOFA and their combination in predicting the occurrence of severe sepsis was analyzed. The relationship between the each indicator and poor prognosis of children with severe sepsis was analyzed.
Results: The plotted ROC curves revealed that the AUC values for predicting the occurrence of severe sepsis were as follows: cTnT: 0.897 (95% CI: 0.787– 0.972), cTnI: 0.881 (95% CI: 0.788– 0.975), p-SOFA: 0.795 (95% CI: 0.701– 0.890), and their combination: 0.935 (95% CI: 0.883– 0.988). Regression analysis showed that cTnT, cTnI, p-SOFA score, CRP and PCT levels were significantly associated with the poor prognosis of children with severe sepsis (p < 0.01).
Conclusion: cTnI, cTnT, and p-SOFA are closely related to the inflammatory response in children with severe sepsis, and the combination of the three indicators can effectively assess the severity of sepsis. The elevated levels of cTnI and cTnT and increased p-SOFA score are closely associated with the poor prognosis of children with severe sepsis.
Keywords: cardiac troponin I, cardiac troponin T, pediatric sequential organ failure assessment score, severe sepsis, prognosis
Department of Pediatrics, Shu Yang Hospital of TCM, Suqian, Jiangsu, 223600, People’s Republic of China
Correspondence: Kai Ge, Department of Pediatrics, Shu Yang Hospital of TCM, No. 28, Shanghai Middle Road, Shuyang County, Suqian, Jiangsu, 223600, People’s Republic of China, Tel +86– 0527-83551087, Email gekai915@yeah.net
Objective: To analyze the prediction value of cardiac troponin I (cTnI), cardiac troponin T (cTnT), and the pediatric Sequential Organ Failure Assessment (p-SOFA) score in children with severe sepsis.
Methods: 80 children with sepsis [Pediatric Critical Illness Score (PCIS) ≥ 70] were selected and categorized into severe sepsis group (PCIS score of 71– 80, n=52) and non-severe sepsis group (PCIS score > 80, n=28) according to the PCIS score, and 50 non-septic children admitted to our hospital during the same period were selected as non-sepsis group. The value of cTnT, cTnI, p-SOFA and their combination in predicting the occurrence of severe sepsis was analyzed. The relationship between the each indicator and poor prognosis of children with severe sepsis was analyzed.
Results: The plotted ROC curves revealed that the AUC values for predicting the occurrence of severe sepsis were as follows: cTnT: 0.897 (95% CI: 0.787– 0.972), cTnI: 0.881 (95% CI: 0.788– 0.975), p-SOFA: 0.795 (95% CI: 0.701– 0.890), and their combination: 0.935 (95% CI: 0.883– 0.988). Regression analysis showed that cTnT, cTnI, p-SOFA score, CRP and PCT levels were significantly associated with the poor prognosis of children with severe sepsis (p < 0.01).
Conclusion: cTnI, cTnT, and p-SOFA are closely related to the inflammatory response in children with severe sepsis, and the combination of the three indicators can effectively assess the severity of sepsis. The elevated levels of cTnI and cTnT and increased p-SOFA score are closely associated with the poor prognosis of children with severe sepsis.
Keywords: cardiac troponin I, cardiac troponin T, pediatric sequential organ failure assessment score, severe sepsis, prognosis