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已发表论文
揭示中医药的分子机制：基于系统生物学的草药治疗阐释
Authors Zhang H, Zhuang X, Lin A, Zhou C, Wei W, Wang X, Wang G
Received 14 July 2025
Accepted for publication 25 January 2026
Published 6 February 2026 Volume 2026:19 553639
DOI https://doi.org/10.2147/IJGM.S553639
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Haitao Zhang,1,2 Xudong Zhuang,2 Aizhu Lin,2 Chunquan Zhou,3 Wenzeng Wei,3 Xinrui Wang,2 Gong Wang3
1Department of Medical Research Center, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Technology Products Research and Development Center, Fujian Academy of Chinese Medical Sciences, Fuzhou, People’s Republic of China
Correspondence: Gong Wang, Email 1056563129@qq.com Xinrui Wang, Email wanxiru@sjtu.edu.cn
Abstract: Systems biology is primarily concerned with the dynamic study of biochemical metabolic processes in physical systems, the interplay of multiple signal transduction routes, gene regulatory networks, and disease causes, among other things. Its most notable aspect is that it merges individual genes with protein studies into thousands of genes or proteins, resulting in “three-dimensional” research. The action advantage of Traditional Chinese Medicine (TCM) is in the integration and modulation of the impact of each individual medication. TCM active components are compatible and blended according to specified conditions, and the integrated medication action is characterized by multi-target and multi-way integration, which is consistent with system biology research theories. Actively introducing new concepts and approaches, such as system biology, will most likely lead to a breakthrough in advancing TCM modernization. This paper aims to review the application of systems biology technologies in TCM research, with a focus on unraveling the multi-component synergistic mechanisms, deciphering the molecular network regulatory patterns, and evaluating the safety and toxicity of TCM compounds, thereby illuminating the molecular basis of TCM’s efficacy in improving complex diseases such as cardiovascular disease and cancer. By adopting the “three-dimensional” research framework of systems biology, this work intends to furnish advanced application references for the holistic view research strategy of Chinese medicine, thereby bridging the systemic research paradigm with traditional TCM theoretical frameworks.
Keywords: systems biology, traditional Chinese medicine, omics technologies, genomics, proteomics, metabolomics, microbiomics
1Department of Medical Research Center, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Technology Products Research and Development Center, Fujian Academy of Chinese Medical Sciences, Fuzhou, People’s Republic of China
Correspondence: Gong Wang, Email 1056563129@qq.com Xinrui Wang, Email wanxiru@sjtu.edu.cn
Abstract: Systems biology is primarily concerned with the dynamic study of biochemical metabolic processes in physical systems, the interplay of multiple signal transduction routes, gene regulatory networks, and disease causes, among other things. Its most notable aspect is that it merges individual genes with protein studies into thousands of genes or proteins, resulting in “three-dimensional” research. The action advantage of Traditional Chinese Medicine (TCM) is in the integration and modulation of the impact of each individual medication. TCM active components are compatible and blended according to specified conditions, and the integrated medication action is characterized by multi-target and multi-way integration, which is consistent with system biology research theories. Actively introducing new concepts and approaches, such as system biology, will most likely lead to a breakthrough in advancing TCM modernization. This paper aims to review the application of systems biology technologies in TCM research, with a focus on unraveling the multi-component synergistic mechanisms, deciphering the molecular network regulatory patterns, and evaluating the safety and toxicity of TCM compounds, thereby illuminating the molecular basis of TCM’s efficacy in improving complex diseases such as cardiovascular disease and cancer. By adopting the “three-dimensional” research framework of systems biology, this work intends to furnish advanced application references for the holistic view research strategy of Chinese medicine, thereby bridging the systemic research paradigm with traditional TCM theoretical frameworks.
Keywords: systems biology, traditional Chinese medicine, omics technologies, genomics, proteomics, metabolomics, microbiomics