120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
系统药理学和多组学揭示柴胡-白芍协同抗抑郁机制：涉及氧化应激、神经免疫平衡和昼夜节律
Authors Zhang H, Wang W, Zhang S, Li X, Li W, Ji C
Received 26 August 2025
Accepted for publication 2 December 2025
Published 24 January 2026 Volume 2026:22 560271
DOI https://doi.org/10.2147/NDT.S560271
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Taro Kishi
Hongcai Zhang,1,2,* Wenran Wang,2,* Shuxiang Zhang,2 Xuan Li,2 Wenlan Li,1 Chenfeng Ji1
1Pharmaceutical College, Harbin University of Commerce, Harbin, 150076, People’s Republic of China; 2Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, 150040, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenlan Li, Email lwldzd@163.com Chenfeng Ji, Email smilejcf001@sina.com
Objective: Based on the classical TCM formulation from Shennong’s Classic of Materia Medica, the Bupleuri Radix–Paeoniae Radix Alba (Chaihu–Baishao, CB) herb pair has long been used to treat depression-like disorders associated with liver stagnation syndrome (ganyu zheng), embodying the TCM principle of shugan jieyu (soothing the liver and relieving depression). This study aims to systematically decipher the multi-target mechanisms underlying CB’s antidepressant effects, bridging traditional use with modern systems pharmacology.
Methods: We employed integrated metabolomics-transcriptomics and behavioral validation in a rat model of chronic unpredictable mild stress (CUMS). Rats were treated with CB water extract for four weeks, and antidepressant effects were assessed through behavioral tests. Serum metabolomics and liver transcriptomics were performed, followed by bioinformatics integration and experimental validation.
Results: CB treatment significantly improved depressive-like behaviors, reversing anhedonia and reducing despair. Multi-omics integration revealed CB’s actions across three key mechanistic domains:.
Oxidative Stress: Regulation of glutathione metabolism, notably reducing oxidized glutathione.
Neuroimmune Balance: Modulation of PI3K/AKT and AMPK/SIRT1 pathways, accompanied by decreased pro-inflammatory cytokines.
Circadian Rhythm: Normalization of core clock genes such as Cry2 and Per2.
Conclusion: The CB herb pair exerts antidepressant effects through synergistic modulation of oxidative stress, neuroimmune balance, and circadian rhythm, providing a systems-level validation of the TCM concept of shugan jieyu. These findings highlight the translational potential of CB as an integrative treatment for depression and offer a modern pharmacological basis for classical TM formulations.
Keywords: depression, radix bupleurum and radix paeoniae alba, metabolomics, transcriptomics, mechanisms of action
1Pharmaceutical College, Harbin University of Commerce, Harbin, 150076, People’s Republic of China; 2Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, 150040, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenlan Li, Email lwldzd@163.com Chenfeng Ji, Email smilejcf001@sina.com
Objective: Based on the classical TCM formulation from Shennong’s Classic of Materia Medica, the Bupleuri Radix–Paeoniae Radix Alba (Chaihu–Baishao, CB) herb pair has long been used to treat depression-like disorders associated with liver stagnation syndrome (ganyu zheng), embodying the TCM principle of shugan jieyu (soothing the liver and relieving depression). This study aims to systematically decipher the multi-target mechanisms underlying CB’s antidepressant effects, bridging traditional use with modern systems pharmacology.
Methods: We employed integrated metabolomics-transcriptomics and behavioral validation in a rat model of chronic unpredictable mild stress (CUMS). Rats were treated with CB water extract for four weeks, and antidepressant effects were assessed through behavioral tests. Serum metabolomics and liver transcriptomics were performed, followed by bioinformatics integration and experimental validation.
Results: CB treatment significantly improved depressive-like behaviors, reversing anhedonia and reducing despair. Multi-omics integration revealed CB’s actions across three key mechanistic domains:.
Oxidative Stress: Regulation of glutathione metabolism, notably reducing oxidized glutathione.
Neuroimmune Balance: Modulation of PI3K/AKT and AMPK/SIRT1 pathways, accompanied by decreased pro-inflammatory cytokines.
Circadian Rhythm: Normalization of core clock genes such as Cry2 and Per2.
Conclusion: The CB herb pair exerts antidepressant effects through synergistic modulation of oxidative stress, neuroimmune balance, and circadian rhythm, providing a systems-level validation of the TCM concept of shugan jieyu. These findings highlight the translational potential of CB as an integrative treatment for depression and offer a modern pharmacological basis for classical TM formulations.
Keywords: depression, radix bupleurum and radix paeoniae alba, metabolomics, transcriptomics, mechanisms of action