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已发表论文
以颈部淋巴结肿大为首发表现的前列腺泡沫腺腺癌：病例报告
Authors Wan Z , Wang J, Wang C, Kong J, Zhao J, Liang W, Peng H, Li M
Received 19 October 2025
Accepted for publication 14 January 2026
Published 24 January 2026 Volume 2026:19 570801
DOI https://doi.org/10.2147/OTT.S570801
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr John Maher
Zhicheng Wan,1,* Junren Wang,2,* Cuicui Wang,1 Jing Kong,3 Jin Zhao,1 Weihua Liang,1 Hao Peng,1,* Man Li1,*
1Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China; 2Department of Pathology, The 948th Hospital of the People’s Liberation Army, Wusu, Xinjiang, People’s Republic of China; 3Department of Oncology, Pingyi County Hospital of Traditional Chinese Medicine, Pingyi, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hao Peng, Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China, Email penghao0421@foxmail.com Man Li, Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China, Email liman570510@126.com
Abstract: Prostate cancer (PCa) is a common urogenital malignancy in elderly males. The typical clinical presentation of advanced PCa includes symptoms of the lower urinary tract. The most common sites of metastasis are the bone and regional lymph nodes. However, PCa with cervical lymphadenopathy as the initial symptom is extremely rare, and one of its variants, foamy gland adenocarcinoma, is even rarer. We present a case of a patient with foamy gland adenocarcinoma of the prostate having enlarged lymph nodes in the neck as the initial symptom. An 81-year-old male was admitted to the hospital with a chief complaint of an enlarged left cervical lymph node without any urological history. Cervical ultrasound showed multiple lymphadenopathies in the left supraclavicular region. The patient underwent a lymph node biopsy, and the pathology results revealed metastatic foamy gland adenocarcinoma of the prostate. Distant lymph node metastasis in PCa is a rare form of metastasis. The initial presentation and tests led to the diagnosis of foamy gland adenocarcinoma of the prostate with cervical lymph node metastasis. Following the diagnosis, the patient received conservative management with androgen deprivation therapy (bicalutamide and goserelin) and zoledronic acid. Unfortunately, he passed away 9 months later due to a COVID-19 infection. We present this rare variant of PCa metastasis to attract the attention of clinicians and pathologists.
Keywords: prostate cancer, foamy gland adenocarcinoma, metastases, cervical lymphadenopathy, primary symptom
1Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China; 2Department of Pathology, The 948th Hospital of the People’s Liberation Army, Wusu, Xinjiang, People’s Republic of China; 3Department of Oncology, Pingyi County Hospital of Traditional Chinese Medicine, Pingyi, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hao Peng, Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China, Email penghao0421@foxmail.com Man Li, Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China, Email liman570510@126.com
Abstract: Prostate cancer (PCa) is a common urogenital malignancy in elderly males. The typical clinical presentation of advanced PCa includes symptoms of the lower urinary tract. The most common sites of metastasis are the bone and regional lymph nodes. However, PCa with cervical lymphadenopathy as the initial symptom is extremely rare, and one of its variants, foamy gland adenocarcinoma, is even rarer. We present a case of a patient with foamy gland adenocarcinoma of the prostate having enlarged lymph nodes in the neck as the initial symptom. An 81-year-old male was admitted to the hospital with a chief complaint of an enlarged left cervical lymph node without any urological history. Cervical ultrasound showed multiple lymphadenopathies in the left supraclavicular region. The patient underwent a lymph node biopsy, and the pathology results revealed metastatic foamy gland adenocarcinoma of the prostate. Distant lymph node metastasis in PCa is a rare form of metastasis. The initial presentation and tests led to the diagnosis of foamy gland adenocarcinoma of the prostate with cervical lymph node metastasis. Following the diagnosis, the patient received conservative management with androgen deprivation therapy (bicalutamide and goserelin) and zoledronic acid. Unfortunately, he passed away 9 months later due to a COVID-19 infection. We present this rare variant of PCa metastasis to attract the attention of clinicians and pathologists.
Keywords: prostate cancer, foamy gland adenocarcinoma, metastases, cervical lymphadenopathy, primary symptom