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已发表论文
游离三碘甲状腺原氨酸作为心肌梗死后室性心律失常的生物标志物：一项多中心前瞻性队列研究
Authors Deng L, Gao Y, Pan L, Wang Q , Deng Y, Wang J , Huang J, Cai D , Zhang Y, Zhu W, Bao X, You H, Cai L, Chen Q , Wei J, Wang RX, Sun L
Received 22 August 2025
Accepted for publication 16 January 2026
Published 27 January 2026 Volume 2026:21 562233
DOI https://doi.org/10.2147/CIA.S562233
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Zhi-Ying Wu
Li Deng,1,2,* Yunlai Gao,1,* Lu Pan,1,* Qingjie Wang,2 Ye Deng,2 Jingyi Wang,2 Jianya Huang,2 Dabei Cai,2 Yang Zhang,3 Wenwu Zhu,4 Xiaojing Bao,1 Huayan You,1 Lei Cai,1 Qianwen Chen,1 Jun Wei,3 Ru-Xing Wang,1 Ling Sun1
1Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People’s Hospital, Wuxi, Jiangsu, 214001, People’s Republic of China; 2Department of Cardiology, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China; 3Department of Cardiovascular Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, People’s Republic of China; 4Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of Nanjing Medical University, Xuzhou Institute of Cardiovascular Disease, Xuzhou, Jiangsu, 221006, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ru-Xing Wang, Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People’s Hospital, 299# Qingyang Road, Wuxi, Jiangsu, 214001, People’s Republic of China, Email ruxingw@njmu.edu.cn Ling Sun, Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People’s Hospital, 299# Qingyang Road, Wuxi, Jiangsu, 214001, People’s Republic of China, Email sunling85125@hotmail.com
Background: The relationship between plasma free triiodothyronine (FT3) levels and the risk of ventricular arrhythmias (VA) in patients with acute myocardial infarction (AMI) remains unclear.
Objective: This study aimed to investigate whether the level of FT3 influences VA in patients with AMI.
Methods: A multicenter prospective study was conducted to collect patients diagnosed with AMI from three centers between January 2018 and December 2021. Patients were categorized into VA and Non-VA groups. FT3 levels were compared between groups, and multivariate logistic regression analyses were performed to evaluate the relationship.
Results: A total of 3277 consecutive patients (mean age: 64.6 years) were included, with 123 (3.9%) developing VA during hospitalization. The VA group had significantly lower FT3 levels compared to the Non-VA group ([3.74 ± 0.77 pmol/L] vs [4.13 ± 0.81 pmol/L], P < 0.001). Multivariate analysis identified FT3 level as an independent predictor of VA risk (adjusted odds ratio [OR]: 0.761; 95% confidence interval [CI]: 0.591– 0.980; P = 0.035). A dose-dependent association was observed, with progressively lower VA risks across increasing FT3 quartiles (Ptrend = 0.007). Each 1 standard deviation decrease in FT3 levels was associated with a 19.9% increased VA risk (OR = 0.801; 95% CI: 0.651– 0.984; P = 0.035).
Conclusion: This study confirmed a significant association between plasma FT3 levels and the risk of ventricular arrhythmias during hospitalization in patients with myocardial infarction. Low FT3 levels are associated with an increased risk of VA in patients with AMI.
Keywords: free triiodothyronine, acute myocardial infarction, ventricular arrhythmia, biomarker, prospective cohort study, diagnosis and prediction
1Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People’s Hospital, Wuxi, Jiangsu, 214001, People’s Republic of China; 2Department of Cardiology, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China; 3Department of Cardiovascular Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, People’s Republic of China; 4Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of Nanjing Medical University, Xuzhou Institute of Cardiovascular Disease, Xuzhou, Jiangsu, 221006, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ru-Xing Wang, Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People’s Hospital, 299# Qingyang Road, Wuxi, Jiangsu, 214001, People’s Republic of China, Email ruxingw@njmu.edu.cn Ling Sun, Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People’s Hospital, 299# Qingyang Road, Wuxi, Jiangsu, 214001, People’s Republic of China, Email sunling85125@hotmail.com
Background: The relationship between plasma free triiodothyronine (FT3) levels and the risk of ventricular arrhythmias (VA) in patients with acute myocardial infarction (AMI) remains unclear.
Objective: This study aimed to investigate whether the level of FT3 influences VA in patients with AMI.
Methods: A multicenter prospective study was conducted to collect patients diagnosed with AMI from three centers between January 2018 and December 2021. Patients were categorized into VA and Non-VA groups. FT3 levels were compared between groups, and multivariate logistic regression analyses were performed to evaluate the relationship.
Results: A total of 3277 consecutive patients (mean age: 64.6 years) were included, with 123 (3.9%) developing VA during hospitalization. The VA group had significantly lower FT3 levels compared to the Non-VA group ([3.74 ± 0.77 pmol/L] vs [4.13 ± 0.81 pmol/L], P < 0.001). Multivariate analysis identified FT3 level as an independent predictor of VA risk (adjusted odds ratio [OR]: 0.761; 95% confidence interval [CI]: 0.591– 0.980; P = 0.035). A dose-dependent association was observed, with progressively lower VA risks across increasing FT3 quartiles (Ptrend = 0.007). Each 1 standard deviation decrease in FT3 levels was associated with a 19.9% increased VA risk (OR = 0.801; 95% CI: 0.651– 0.984; P = 0.035).
Conclusion: This study confirmed a significant association between plasma FT3 levels and the risk of ventricular arrhythmias during hospitalization in patients with myocardial infarction. Low FT3 levels are associated with an increased risk of VA in patients with AMI.
Keywords: free triiodothyronine, acute myocardial infarction, ventricular arrhythmia, biomarker, prospective cohort study, diagnosis and prediction