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已发表论文
病例报告：免疫功能正常年轻男性罕见社区获得性肺炎合并耐甲氧西林金黄色葡萄球菌和新型隐球菌感染
Authors Ye J , Sun L, Lv D, Zhao S, Mao Q, Xu Y, Chen Y
Received 15 November 2025
Accepted for publication 22 January 2026
Published 27 January 2026 Volume 2026:19 581754
DOI https://doi.org/10.2147/IDR.S581754
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Jiayuan Ye,1,* Lu Sun,2,* Dong Lv,3 Shanshan Zhao,4 Qiuqin Mao,5 Yuxiang Xu,6 Yan Chen2
1Department of Infectious Diseases, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 2Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3Department of Respiratory, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 4Department of Clinical Laboratory, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 5Department of Nursing, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 6Medical Department, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Chen, Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, People’s Republic of China, Email chenyan@zju.edu.cn Yuxiang Xu, Medical Department, Shangyu People’s Hospital of Shaoxing, Shaoxing University, No. 517, Minsheng Avenue, Baiguan Street, Shangyu District, Shaoxing, Zhejiang, People’s Republic of China, Tel + 86 0575 82185313, Email longchanxiao1991@163.com
Abstract: Cryptococcal pneumonia predominantly occurs in immunocompromised patients, but its incidence among immunocompetent individuals has been increasing in recent years. However, cases of co-infection with Cryptococcus neoformans and community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in immunocompetent hosts remain exceedingly rare. This study reports on a previously healthy 30-year-old male who presented with 20-days cough and 1-day fever. Through nanopore targeted sequencing (NTS) of bronchoalveolar lavage fluid (BLAF) and traditional microbial culture, he was ultimately diagnosed with a co-infection of C. neoformans and CA-MRSA. The patient showed significant improvement after treatment with oral linezolid (0.6 g twice daily) for 2 weeks and oral fluconazole (400 mg once daily) for 6 months. This case highlights that even immunocompetent individuals can simultaneously contract multiple community-acquired pathogens, while also underscoring the clinical utility of NTS in the early diagnosis of co-infections and detection of resistance genes.
Keywords: community-acquired methicillin-resistant Staphylococcus aureus, Cryptococcus neoformans, pulmonary infection, nanopore sequencing, case report
1Department of Infectious Diseases, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 2Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3Department of Respiratory, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 4Department of Clinical Laboratory, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 5Department of Nursing, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 6Medical Department, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Chen, Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, People’s Republic of China, Email chenyan@zju.edu.cn Yuxiang Xu, Medical Department, Shangyu People’s Hospital of Shaoxing, Shaoxing University, No. 517, Minsheng Avenue, Baiguan Street, Shangyu District, Shaoxing, Zhejiang, People’s Republic of China, Tel + 86 0575 82185313, Email longchanxiao1991@163.com
Abstract: Cryptococcal pneumonia predominantly occurs in immunocompromised patients, but its incidence among immunocompetent individuals has been increasing in recent years. However, cases of co-infection with Cryptococcus neoformans and community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in immunocompetent hosts remain exceedingly rare. This study reports on a previously healthy 30-year-old male who presented with 20-days cough and 1-day fever. Through nanopore targeted sequencing (NTS) of bronchoalveolar lavage fluid (BLAF) and traditional microbial culture, he was ultimately diagnosed with a co-infection of C. neoformans and CA-MRSA. The patient showed significant improvement after treatment with oral linezolid (0.6 g twice daily) for 2 weeks and oral fluconazole (400 mg once daily) for 6 months. This case highlights that even immunocompetent individuals can simultaneously contract multiple community-acquired pathogens, while also underscoring the clinical utility of NTS in the early diagnosis of co-infections and detection of resistance genes.
Keywords: community-acquired methicillin-resistant Staphylococcus aureus, Cryptococcus neoformans, pulmonary infection, nanopore sequencing, case report