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已发表论文
通过合成条件调控聚多巴胺纳米颗粒尺寸并界定其抗氧化和神经保护效力
Authors Huang Q , Zou J , Luan F, Shi Y
Received 14 November 2025
Accepted for publication 16 January 2026
Published 27 January 2026 Volume 2026:21 581479
DOI https://doi.org/10.2147/IJN.S581479
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Dong Wang
Qianqian Huang, Junbo Zou, Fei Luan, Yajun Shi
Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, People’s Republic of China
Correspondence: Yajun Shi, Email 2051004@sntcm.edu.cn
Introduction: Oxidative stress is a central pathological process in neurodegenerative diseases, driving the need for neuroprotective agents capable of scavenging reactive oxygen species (ROS). Polydopamine nanoparticles (PDA) hold promise due to their antioxidant properties, but their biomedical application has been limited by challenges in achieving precise size control.
Methods: We established a controllable synthesis of PDA by systematically optimizing the alkaline polymerization parameters, including pH, temperature, and reaction time. We also evaluated their antioxidant and neuroprotective efficacy.
Results: This approach yielded monodisperse, spherical PDA with a diameter of approximately 60 nm. The synthesized NPs exhibited potent ROS-scavenging capacity, effectively protected neuronal cells from oxidative stress, and promoted microglial polarization from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype.
Discussion: Our study not only systematically establishes the technical parameters for the controlled preparation of PDA but also elucidates the dual mechanisms of antioxidant activity and immunomodulation. Those results demonstrate their potential as efficient neuroprotective nanotherapeutics, while providing a solid theoretical and experimental foundation for related drug development.
Keywords: polydopamine, particle size, react conditions, reactive oxygen species scavenge, microglial polarization
Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, People’s Republic of China
Correspondence: Yajun Shi, Email 2051004@sntcm.edu.cn
Introduction: Oxidative stress is a central pathological process in neurodegenerative diseases, driving the need for neuroprotective agents capable of scavenging reactive oxygen species (ROS). Polydopamine nanoparticles (PDA) hold promise due to their antioxidant properties, but their biomedical application has been limited by challenges in achieving precise size control.
Methods: We established a controllable synthesis of PDA by systematically optimizing the alkaline polymerization parameters, including pH, temperature, and reaction time. We also evaluated their antioxidant and neuroprotective efficacy.
Results: This approach yielded monodisperse, spherical PDA with a diameter of approximately 60 nm. The synthesized NPs exhibited potent ROS-scavenging capacity, effectively protected neuronal cells from oxidative stress, and promoted microglial polarization from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype.
Discussion: Our study not only systematically establishes the technical parameters for the controlled preparation of PDA but also elucidates the dual mechanisms of antioxidant activity and immunomodulation. Those results demonstrate their potential as efficient neuroprotective nanotherapeutics, while providing a solid theoretical and experimental foundation for related drug development.
Keywords: polydopamine, particle size, react conditions, reactive oxygen species scavenge, microglial polarization