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已发表论文
日本人群γ-谷氨酰转移酶/高密度脂蛋白胆固醇比值与动脉僵硬度的非线性关联：基于横断面研究的二次分析
Authors Shi LM, Gao YX, Yang JQ, Wang LL, Wang GM
Received 13 August 2025
Accepted for publication 15 January 2026
Published 27 January 2026 Volume 2026:22 560291
DOI https://doi.org/10.2147/VHRM.S560291
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Roland Asmar
Liu-Ming Shi,1 Yu-Xu Gao,1 Jia-Qi Yang,1 Li-Li Wang,2 Gui-Ming Wang1
1Department of Vascular Surgery, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department of Gynaecology, The First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China
Correspondence: Gui-Ming Wang, Email wangguiming505@163.com
Background: Evidences suggested that gamma-glutamyltransferase (GGT) to high-density lipoprotein cholesterol (HDL-C) ratio (GTHR) was a reliable surrogate indicator for fatty liver disease, diabetes, metabolic syndrome. However, the relationship between GTHR and the presence of arterial stiffness remains unclear in healthy population. In the present study, we aimed to explore the association between GTHR and arterial stiffness (AS) in a health check-up population from Japan.
Methods: This study is a secondary analysis from a health check-up program carried out at Murakami Memorial Hospital, Gifu, Japan between March 2004 and December 2012. A total of 912 individuals were included in this study. Patients were divided into three groups according to the tertiles of LogGTHR. The univariate linear regression model and the multivariate models were performed to explore the association between between LogGTHR and baPWV. Smoothed curve fit analysis was used to explore the linear or the nonlinear relationship between LogGTHR and baPWV. The modification and interaction of subgroup were inspected by the likelihood ration test.
Results: After adjusting for confounders, there is a nonlinear relationship between LogGTHR and baPWV (β=30.08, 95%CI: − 33.12 to 93.29, P=0.351). The inflection point was 1.43. When K< 1.43 (80.37% of the participants), the relationship was positively correlated (β=165.15, 95%CI: 62.72 to 267.58, P=0.0016), while when ≥ 1.43, there was a negative association between LogGTHR and baPWV (β= − 106.23, 95%CI: – 209.25 to − 3.21, P=0.0436). Subgroup analysis suggested that LogGTHR was not associated with baPWV in any of these subgroups.
Conclusion: In this cross-sectional study, there was a nonlinear positive association between LogGTHR and AS. LogGTHR was positively related with baPWV when less than 1.43, while this association was negative when LogGTHR was > 1.43.
Keywords: gamma-glutamyltransferase to high-density lipoprotein cholesterol ratio, brachial-ankle pulse wave velocity, arterial stiffness
1Department of Vascular Surgery, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department of Gynaecology, The First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China
Correspondence: Gui-Ming Wang, Email wangguiming505@163.com
Background: Evidences suggested that gamma-glutamyltransferase (GGT) to high-density lipoprotein cholesterol (HDL-C) ratio (GTHR) was a reliable surrogate indicator for fatty liver disease, diabetes, metabolic syndrome. However, the relationship between GTHR and the presence of arterial stiffness remains unclear in healthy population. In the present study, we aimed to explore the association between GTHR and arterial stiffness (AS) in a health check-up population from Japan.
Methods: This study is a secondary analysis from a health check-up program carried out at Murakami Memorial Hospital, Gifu, Japan between March 2004 and December 2012. A total of 912 individuals were included in this study. Patients were divided into three groups according to the tertiles of LogGTHR. The univariate linear regression model and the multivariate models were performed to explore the association between between LogGTHR and baPWV. Smoothed curve fit analysis was used to explore the linear or the nonlinear relationship between LogGTHR and baPWV. The modification and interaction of subgroup were inspected by the likelihood ration test.
Results: After adjusting for confounders, there is a nonlinear relationship between LogGTHR and baPWV (β=30.08, 95%CI: − 33.12 to 93.29, P=0.351). The inflection point was 1.43. When K< 1.43 (80.37% of the participants), the relationship was positively correlated (β=165.15, 95%CI: 62.72 to 267.58, P=0.0016), while when ≥ 1.43, there was a negative association between LogGTHR and baPWV (β= − 106.23, 95%CI: – 209.25 to − 3.21, P=0.0436). Subgroup analysis suggested that LogGTHR was not associated with baPWV in any of these subgroups.
Conclusion: In this cross-sectional study, there was a nonlinear positive association between LogGTHR and AS. LogGTHR was positively related with baPWV when less than 1.43, while this association was negative when LogGTHR was > 1.43.
Keywords: gamma-glutamyltransferase to high-density lipoprotein cholesterol ratio, brachial-ankle pulse wave velocity, arterial stiffness