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已发表论文
前列腺六跨膜上皮抗原1通过Wnt/β-catenin信号通路在体内外促进HCC增殖和转移
Authors Liu H, Gao J , Liu X, Guo W, Zhang S
Received 17 July 2025
Accepted for publication 20 January 2026
Published 28 January 2026 Volume 2026:18 554545
DOI https://doi.org/10.2147/CMAR.S554545
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Kattesh Katti
Haichao Liu,1– 4 Jie Gao,1– 3 Xudong Liu,1– 3 Wenzhi Guo,1– 3 Shuijun Zhang1– 3
1Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Henan Key Laboratory for Digestive Organ Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3Henan Engineering Technology Research Center for Organ Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 4Department of Hepatobiliary and Pancreatic Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, People’s Republic of China
Correspondence: Shuijun Zhang, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China, Email zhangshuijun@zzu.edu.cn
Objective: To investigate the role and underlying mechanism of Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) in Hepatocellular carcinoma (HCC) progression, and to validate its potential as a therapeutic target.
Materials and Methods: In this study, STEAP1-knockdown models were used to evaluate cell proliferation, invasion and migration. RNA sequencing (RNA-seq) were performed to explore downstream mechanisms. Subcutaneous Xenograft Model in nude mice was used to investigate the role of STEAP1 in the proliferation of HCC in vivo.
Results: STEAP1 knockdown significantly inhibited HCC cell proliferation, invasion, and migration, downregulated the expression of EMT-related proteins, and suppressed activation of the Wnt signaling pathway. In vivo, STEAP1 silencing effectively reduced the growth of subcutaneous tumors in nude mice.
Conclusion: STEAP1 promotes HCC growth and metastasis by activating the Wnt/β-catenin signaling pathway, and may serve as a promising therapeutic target for HCC.
Keywords: HCC, STEAP1, Wnt/β-catenin, metastasis
1Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Henan Key Laboratory for Digestive Organ Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3Henan Engineering Technology Research Center for Organ Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 4Department of Hepatobiliary and Pancreatic Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, People’s Republic of China
Correspondence: Shuijun Zhang, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China, Email zhangshuijun@zzu.edu.cn
Objective: To investigate the role and underlying mechanism of Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) in Hepatocellular carcinoma (HCC) progression, and to validate its potential as a therapeutic target.
Materials and Methods: In this study, STEAP1-knockdown models were used to evaluate cell proliferation, invasion and migration. RNA sequencing (RNA-seq) were performed to explore downstream mechanisms. Subcutaneous Xenograft Model in nude mice was used to investigate the role of STEAP1 in the proliferation of HCC in vivo.
Results: STEAP1 knockdown significantly inhibited HCC cell proliferation, invasion, and migration, downregulated the expression of EMT-related proteins, and suppressed activation of the Wnt signaling pathway. In vivo, STEAP1 silencing effectively reduced the growth of subcutaneous tumors in nude mice.
Conclusion: STEAP1 promotes HCC growth and metastasis by activating the Wnt/β-catenin signaling pathway, and may serve as a promising therapeutic target for HCC.
Keywords: HCC, STEAP1, Wnt/β-catenin, metastasis