120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
湿性年龄相关性黄斑变性中可溶性sCD13的表达特征及其诊断价值和相关性研究
Authors Zhang B, Tian F, Hu X, Hu Y, Li W
Received 11 July 2025
Accepted for publication 3 January 2026
Published 28 January 2026 Volume 2026:19 553165
DOI https://doi.org/10.2147/IJGM.S553165
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Brian C. Gilger
Bing Zhang,1 Fei Tian,1 XueJin Hu,2 Yong Hu,3 WenGang Li4
1Department of Inspection Division, Huanggang Central Hospital, Huanggang, Hubei, 438000, People’s Republic of China; 2Department of Inspection Division, Tongshan People’s Hospital, Xianning, Hubei, 437600, People’s Republic of China; 3Department of Inspection Division, Yiling Hospital of Yichang, Yichang, Hubei, 443100, People’s Republic of China; 4Department of Inspection Division, People’s Hospital of Chibi, Chibi, Hubei, 437300, People’s Republic of China
Correspondence: WenGang Li, Department of Inspection Division, People’s Hospital of Chibi, No. 260, Hubei Avenue, Chibi, Hubei, 437300, People’s Republic of China, Email lwenganghghb@outlook.com
Objective: This study explored the level of soluble CD13 (sCD13) and its correlation with angiogenic factors, evaluating the predictive efficacy of sCD13 in wet age-related macular degeneration (wAMD).
Methods: 200 patients were included (58 in Non AMD group, 42 in Early AMD group, and 100 in wAMD group). Detailed routine and ophthalmologic examinations were performed on all subjects, and the central retinal thickness (CRT) and ganglion cell-inner plexiform layer (GCIPL) were determined. The concentration of sCD13 was compared. The correlation of sCD13 with PDGF, hsCRP and IL-8 was analyzed. ROC curves were plotted and the diagnostic value of sCD13 was assessed by area under the curve (AUC).
Results: The sCD13 concentration of patients in the wAMD group (20.41 ± 5.86 U/mL) was higher. Age, history of smoking, CRT, hsCRP and IL-8 were higher in the wAMD group, while mean GCIPL, BCVA, and PDGF were lower. sCD13 was positively correlated with hsCRP (r = 0.505) and IL-8 (r = 0.193) and negatively correlated with PDGF (r = − 0.241). sCD13 had predictive efficacy in distinguishing wAMD from non AMD and early AMD, with AUC values of 0.74 and 0.61, respectively (P < 0.05).
Conclusion: sCD13 concentration in the affected eyes of wAMD patients is abnormally elevated and associated with elevated serum hsCRP and IL-8 levels and decreased PDGF. These results suggest that elevated sCD13 may promote the development of wAMD, emphasizing the importance of early control of sCD13 levels.
Keywords: age-related macular degeneration, soluble CD13, retinal pigment epithelium, diagnosis
1Department of Inspection Division, Huanggang Central Hospital, Huanggang, Hubei, 438000, People’s Republic of China; 2Department of Inspection Division, Tongshan People’s Hospital, Xianning, Hubei, 437600, People’s Republic of China; 3Department of Inspection Division, Yiling Hospital of Yichang, Yichang, Hubei, 443100, People’s Republic of China; 4Department of Inspection Division, People’s Hospital of Chibi, Chibi, Hubei, 437300, People’s Republic of China
Correspondence: WenGang Li, Department of Inspection Division, People’s Hospital of Chibi, No. 260, Hubei Avenue, Chibi, Hubei, 437300, People’s Republic of China, Email lwenganghghb@outlook.com
Objective: This study explored the level of soluble CD13 (sCD13) and its correlation with angiogenic factors, evaluating the predictive efficacy of sCD13 in wet age-related macular degeneration (wAMD).
Methods: 200 patients were included (58 in Non AMD group, 42 in Early AMD group, and 100 in wAMD group). Detailed routine and ophthalmologic examinations were performed on all subjects, and the central retinal thickness (CRT) and ganglion cell-inner plexiform layer (GCIPL) were determined. The concentration of sCD13 was compared. The correlation of sCD13 with PDGF, hsCRP and IL-8 was analyzed. ROC curves were plotted and the diagnostic value of sCD13 was assessed by area under the curve (AUC).
Results: The sCD13 concentration of patients in the wAMD group (20.41 ± 5.86 U/mL) was higher. Age, history of smoking, CRT, hsCRP and IL-8 were higher in the wAMD group, while mean GCIPL, BCVA, and PDGF were lower. sCD13 was positively correlated with hsCRP (r = 0.505) and IL-8 (r = 0.193) and negatively correlated with PDGF (r = − 0.241). sCD13 had predictive efficacy in distinguishing wAMD from non AMD and early AMD, with AUC values of 0.74 and 0.61, respectively (P < 0.05).
Conclusion: sCD13 concentration in the affected eyes of wAMD patients is abnormally elevated and associated with elevated serum hsCRP and IL-8 levels and decreased PDGF. These results suggest that elevated sCD13 may promote the development of wAMD, emphasizing the importance of early control of sCD13 levels.
Keywords: age-related macular degeneration, soluble CD13, retinal pigment epithelium, diagnosis