120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
围产期获得性血友病A患者剖宫产后发生失血性休克和巨大腹壁血肿：病例报告
Authors Huang Q, Chen X, Wu X, Xu S, Zheng X, Li X, Zhang S, Fu S
Received 18 August 2025
Accepted for publication 9 January 2026
Published 28 January 2026 Volume 2026:18 557109
DOI https://doi.org/10.2147/IJWH.S557109
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Vinay Kumar
Qiaoyao Huang,1,* Xiaojun Chen,1,* Xiaohuan Wu,2 Shilian Xu,1 Xiaohang Zheng,1 Xueyan Li,3 Shuning Zhang,3 Shuai Fu3
1Department of Gynaecology and Obstetrics, Shenshan Medical Central, Memorial Hospital of Sun Yat-Sen University, Shanwei, 516600, People’s Republic of China; 2Department of Internal Medicine, Shenshan Medical Central, Memorial Hospital of Sun Yat-sen University, Shanwei, 516600, People’s Republic of China; 3Department of Gynaecology and Obstetrics, Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Shuai Fu, Email fush7@mail.sysu.edu.cn Shuning Zhang, Email qq841212@126.com
Abstract: Acquired Hemophilia A (AHA), a rare bleeding disorder caused by autoimmune suppression of coagulation factor VIII(FVIII), has a low incidence in perinatal women but carries significant risks of severe hemorrhage. The lack of consensus guidelines and limited clinical data from developing countries underscore the importance of this case report. Consequently, this report informs clinical practice and expands the evidence base for the treatment of AHA. This case describes an extensive abdominal wall hematoma and hemorrhagic shock following a cesarean section in a patient. The condition was successfully managed through comprehensive interventions, including shock resuscitation, endovascular embolization, pharmacological hemostatic therapy, removal of circulating immune complexes, and immunosuppressive therapy. AHA usually causes acute bleeding, and early identification and removal of acquired inhibitors are the main treatment methods. In such cases, endovascular embolization is an effective procedure to control bleeding.
Keywords: acquired hemophilia A, activated partial thromboplastin time, factor VIII inhibitors, endovascular embolization, perinatal
1Department of Gynaecology and Obstetrics, Shenshan Medical Central, Memorial Hospital of Sun Yat-Sen University, Shanwei, 516600, People’s Republic of China; 2Department of Internal Medicine, Shenshan Medical Central, Memorial Hospital of Sun Yat-sen University, Shanwei, 516600, People’s Republic of China; 3Department of Gynaecology and Obstetrics, Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Shuai Fu, Email fush7@mail.sysu.edu.cn Shuning Zhang, Email qq841212@126.com
Abstract: Acquired Hemophilia A (AHA), a rare bleeding disorder caused by autoimmune suppression of coagulation factor VIII(FVIII), has a low incidence in perinatal women but carries significant risks of severe hemorrhage. The lack of consensus guidelines and limited clinical data from developing countries underscore the importance of this case report. Consequently, this report informs clinical practice and expands the evidence base for the treatment of AHA. This case describes an extensive abdominal wall hematoma and hemorrhagic shock following a cesarean section in a patient. The condition was successfully managed through comprehensive interventions, including shock resuscitation, endovascular embolization, pharmacological hemostatic therapy, removal of circulating immune complexes, and immunosuppressive therapy. AHA usually causes acute bleeding, and early identification and removal of acquired inhibitors are the main treatment methods. In such cases, endovascular embolization is an effective procedure to control bleeding.
Keywords: acquired hemophilia A, activated partial thromboplastin time, factor VIII inhibitors, endovascular embolization, perinatal