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已发表论文
Janus膜作为骨缺损修复多功能纳米结构：进展、挑战和临床转化
Authors Liu J, Liu S, Tan R, Chang W, Chen Z, Wang Y, Zhou P, Sun H , Xu Z
Received 25 August 2025
Accepted for publication 19 January 2026
Published 29 January 2026 Volume 2026:21 563011
DOI https://doi.org/10.2147/IJN.S563011
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Yan Shen
Jiachen Liu,1,* Shuyan Liu,1,* Rui Tan,1,* Wenliao Chang,1 Zhuo Chen,1 Yimin Wang,1 Peng Zhou,1 Han Sun,1 Zhonghua Xu2
1Articular Orthopaedics, Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of China; 2Department of Orthopedics, Affiliated Jintan Hospital of Jiangsu University, Changzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Han Sun, Email sh4060@suda.edu.cn Zhonghua Xu, Email zhonghuaxucz@163.com
Abstract: Bone defect repair, particularly for critically sized defects, remains a formidable clinical challenge owing to the limitations of conventional bone grafts and single-functional scaffolds. Janus membranes, with their asymmetric structure and capacity for multi-functional integration, offer an innovative “all-in-one” solution for bone tissue engineering. This review systematically outlines recent advancements in Janus membranes for bone repair, focusing on three core aspects: nanofabrication strategies for achieving asymmetric properties (eg wettability, charge, and porosity), multi-functional designs that mimic the natural periosteum for guided bone regeneration, antibacterial activity, soft-tissue integration, and haemostasis, and clinical translation potential along with future perspectives. This review summarises the progress in the use of Janus membranes as multi-functional nanostructures for bone regeneration. It systematically introduces the manufacturing techniques for Janus membranes, such as the layer-by-layer method and ion-modification approaches. Furthermore, it focuses on the dual-functional and multi-functional designs of Janus membranes and their integration with nanotechnology. In addition, we delve into the current challenges (eg complexity in manufacturing processes and limited research on material mechanical properties) and propose potential solutions, such as intelligent manufacturing (eg 3D printing) and dynamic response systems. This review provides a comprehensive reference for the field and promotes the clinical translation of Janus membranes.
Keywords: bone defect repair, Janus membranes, osteogenesis, bone tissue engineering, multi-functional integration
1Articular Orthopaedics, Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of China; 2Department of Orthopedics, Affiliated Jintan Hospital of Jiangsu University, Changzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Han Sun, Email sh4060@suda.edu.cn Zhonghua Xu, Email zhonghuaxucz@163.com
Abstract: Bone defect repair, particularly for critically sized defects, remains a formidable clinical challenge owing to the limitations of conventional bone grafts and single-functional scaffolds. Janus membranes, with their asymmetric structure and capacity for multi-functional integration, offer an innovative “all-in-one” solution for bone tissue engineering. This review systematically outlines recent advancements in Janus membranes for bone repair, focusing on three core aspects: nanofabrication strategies for achieving asymmetric properties (eg wettability, charge, and porosity), multi-functional designs that mimic the natural periosteum for guided bone regeneration, antibacterial activity, soft-tissue integration, and haemostasis, and clinical translation potential along with future perspectives. This review summarises the progress in the use of Janus membranes as multi-functional nanostructures for bone regeneration. It systematically introduces the manufacturing techniques for Janus membranes, such as the layer-by-layer method and ion-modification approaches. Furthermore, it focuses on the dual-functional and multi-functional designs of Janus membranes and their integration with nanotechnology. In addition, we delve into the current challenges (eg complexity in manufacturing processes and limited research on material mechanical properties) and propose potential solutions, such as intelligent manufacturing (eg 3D printing) and dynamic response systems. This review provides a comprehensive reference for the field and promotes the clinical translation of Janus membranes.
Keywords: bone defect repair, Janus membranes, osteogenesis, bone tissue engineering, multi-functional integration